Single cell type - IDS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IDS
Gene descriptionⁱ Full gene name according to HGNC.	Iduronate 2-sulfatase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IDS is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF331	Zinc finger protein 331	0.5863	7
IRGM	Immunity related GTPase M	0.5692	7
TSPYL2	TSPY like 2	0.5348	7
CXCR4	C-X-C motif chemokine receptor 4	0.5336	24
ALG13	ALG13 UDP-N-acetylglucosaminyltransferase subunit	0.5305	24
STK4	Serine/threonine kinase 4	0.5117	24
SGTB	Small glutamine rich tetratricopeptide repeat containing beta	0.5067	24
SYNGR3	Synaptogyrin 3	0.5015	8
NAP1L2	Nucleosome assembly protein 1 like 2	0.5015	56
PDE7A	Phosphodiesterase 7A	0.4987	24
NKRF	NFKB repressing factor	0.4968	41
ZDBF2	Zinc finger DBF-type containing 2	0.4957	40
TNFRSF9	TNF receptor superfamily member 9	0.4946	24
PREPL	Prolyl endopeptidase like	0.4904	8
STAM	Signal transducing adaptor molecule	0.4813	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	53.7 nTPM
Adipose tissue	54.2 nTPM
Breast	53.3 nTPM

Alveolar cells type 1	99.3 nTPM
Lung	99.3 nTPM

Alveolar cells type 2	64.4 nTPM
Lung	64.4 nTPM

Astrocytes	55.8 nTPM
Brain	55.8 nTPM

B-cells	150.9 nTPM
Colon	295.5 nTPM
Stomach	287.9 nTPM
Adipose tissue	248.7 nTPM
Lymph node	155.5 nTPM
Spleen	122.9 nTPM
Breast	113.7 nTPM
Bone marrow	82.5 nTPM
Liver	68.2 nTPM
PBMC	67.1 nTPM
Kidney	66.6 nTPM

Dendritic cells	158.5 nTPM
Adipose tissue	202.2 nTPM
Breast	161.8 nTPM
PBMC	111.6 nTPM

Endothelial cells	44.7 nTPM
Eye	89.8 nTPM
Liver	82.6 nTPM
Lung	59.3 nTPM
Breast	53.8 nTPM
Skin	52.8 nTPM
Skeletal muscle	52.1 nTPM
Esophagus	38.2 nTPM
Prostate	37.3 nTPM
Heart muscle	36.3 nTPM
Ovary	36.0 nTPM
Testis	33.5 nTPM
Endometrium	24.3 nTPM
Pancreas	15.5 nTPM
Placenta	14.8 nTPM

Enteroendocrine cells	168.4 nTPM
Colon	174.1 nTPM
Rectum	162.6 nTPM

Fibroblasts	78.3 nTPM
Prostate	124.6 nTPM
Lung	124.0 nTPM
Esophagus	101.0 nTPM
Skin	86.6 nTPM
Skeletal muscle	83.8 nTPM
Adipose tissue	81.6 nTPM
Heart muscle	79.7 nTPM
Stomach	71.3 nTPM
Breast	65.5 nTPM
Ovary	23.0 nTPM
Placenta	19.7 nTPM

Intestinal goblet cells	29.0 nTPM
Small intestine	37.8 nTPM
Rectum	27.1 nTPM
Colon	22.1 nTPM

Macrophages	98.4 nTPM
Adipose tissue	177.1 nTPM
Breast	130.0 nTPM
Skeletal muscle	126.6 nTPM
Lung	121.6 nTPM
Spleen	118.2 nTPM
Stomach	105.5 nTPM
Endometrium	93.3 nTPM
Ovary	88.6 nTPM
Testis	86.5 nTPM
Esophagus	85.0 nTPM
Pancreas	84.2 nTPM
Kidney	76.3 nTPM
Bone marrow	72.4 nTPM
Prostate	56.1 nTPM
PBMC	54.6 nTPM

Paneth cells	50.3 nTPM
Colon	72.5 nTPM
Small intestine	48.8 nTPM
Rectum	29.7 nTPM

Plasma cells	98.8 nTPM
Adipose tissue	193.0 nTPM
Stomach	125.3 nTPM
Esophagus	67.8 nTPM
Bone marrow	54.4 nTPM
Spleen	53.3 nTPM

Respiratory ciliated cells	112.4 nTPM
Bronchus	138.8 nTPM
Lung	86.0 nTPM

Smooth muscle cells	65.2 nTPM
Breast	94.3 nTPM
Prostate	90.7 nTPM
Esophagus	88.3 nTPM
Adipose tissue	86.0 nTPM
Skin	84.4 nTPM
Skeletal muscle	83.9 nTPM
Heart muscle	70.8 nTPM
Endometrium	42.7 nTPM
Ovary	33.8 nTPM
Pancreas	25.8 nTPM
Bronchus	16.1 nTPM

Basal keratinocytes	33.1 nTPM
Skin	33.1 nTPM

Basal prostatic cells	60.6 nTPM
Prostate	60.6 nTPM

Basal respiratory cells	44.0 nTPM
Bronchus	44.0 nTPM

Basal squamous epithelial cells	20.5 nTPM
Esophagus	20.5 nTPM

T-cells	183.9 nTPM
Adipose tissue	361.7 nTPM
Colon	281.3 nTPM
Stomach	281.1 nTPM
Breast	280.1 nTPM
Skeletal muscle	235.6 nTPM
Ovary	215.8 nTPM
Liver	180.8 nTPM
Endometrium	180.7 nTPM
Skin	173.2 nTPM
Spleen	153.0 nTPM
Prostate	151.5 nTPM
Lymph node	131.1 nTPM
Esophagus	131.0 nTPM
Lung	120.0 nTPM
Bone marrow	94.7 nTPM
PBMC	86.2 nTPM
Kidney	68.5 nTPM

Undifferentiated cells	17.1 nTPM
Rectum	22.2 nTPM
Small intestine	15.5 nTPM
Colon	13.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC