Cell line - IGKJ4 - The Human Protein Atlas

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IGKJ4

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGKJ4
Gene descriptionⁱ Full gene name according to HGNC.	Immunoglobulin kappa joining 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Immunoglobulin genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	HDLM-2 - Immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO, Daudi, HDLM-2, RPMI-8226, SH-SY5Y, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at transcript level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

IGKJ4 is part of cluster 44 HDLM-2 - Immune response with confidenceⁱ 1
446 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGKJ3	Immunoglobulin kappa joining 3	0.8601	44
IGKV2D-28	Immunoglobulin kappa variable 2D-28	0.8259	44
CD86	CD86 molecule	0.8251	44
IGKV1D-37	Immunoglobulin kappa variable 1D-37 (non-functional)	0.8134	44
HAVCR2	Hepatitis A virus cellular receptor 2	0.8026	44
IGKJ2	Immunoglobulin kappa joining 2	0.7982	44
LSP1	Lymphocyte specific protein 1	0.7913	44
IL10RA	Interleukin 10 receptor subunit alpha	0.7812	44
IL3RA	Interleukin 3 receptor subunit alpha	0.7773	44
PROB1	Proline rich basic protein 1	0.7749	44
ARID5A	AT-rich interaction domain 5A	0.7583	44
KRTAP29-1	Keratin associated like protein 29-1	0.7575	44
HLA-DQA1	Major histocompatibility complex, class II, DQ alpha 1	0.7528	44
IL1R2	Interleukin 1 receptor type 2	0.7516	44
HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1	0.7455	44

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.