Cell line - IGLV3-21 - The Human Protein Atlas

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IGLV3-21

SUMMARY

TISSUE

BRAIN

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CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGLV3-21
Gene descriptionⁱ Full gene name according to HGNC.	Immunoglobulin lambda variable 3-21
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Immunoglobulin genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	REH - Unknown function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (REH)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

IGLV3-21 is part of cluster 14 REH - Unknown function with confidenceⁱ 1
148 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RERGL	RERG like	0.9992	14
GABRA4	Gamma-aminobutyric acid type A receptor subunit alpha4	0.9990	14
SH2D4B	SH2 domain containing 4B	0.9990	14
ANKRD30BL	Ankyrin repeat domain 30B like	0.9990	14
IGLL1	Immunoglobulin lambda like polypeptide 1	0.9964	14
TRDV2	T cell receptor delta variable 2	0.9957	14
CMTM2	CKLF like MARVEL transmembrane domain containing 2	0.9941	14
AL035699.1	Novel protein	0.9911	14
ARRDC5	Arrestin domain containing 5	0.9889	14
HMX2	H6 family homeobox 2	0.9887	14
ECE2	Endothelin converting enzyme 2	0.9836	14
TAFA1	TAFA chemokine like family member 1	0.9808	14
AC233755.1	Immunoglobulin heavy variable 4-38-2-like	0.9796	14
KLHL33	Kelch like family member 33	0.9785	14
KCNN1	Potassium calcium-activated channel subfamily N member 1	0.9785	14

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.