Single cell type - CEBPZOS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CEBPZOS
Gene descriptionⁱ Full gene name according to HGNC.	CEBPZ opposite strand
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CEBPZOS is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CFAP97	Cilia and flagella associated protein 97	0.5847	66
SF3B6	Splicing factor 3b subunit 6	0.5718	22
NDUFB8	NADH:ubiquinone oxidoreductase subunit B8	0.5465	7
BORCS8	BLOC-1 related complex subunit 8	0.5289	7
SDHAF3	Succinate dehydrogenase complex assembly factor 3	0.5261	39
BORCS7	BLOC-1 related complex subunit 7	0.5251	39
FAAP20	FA core complex associated protein 20	0.5201	7
IER3IP1	Immediate early response 3 interacting protein 1	0.5069	67
C15orf40	Chromosome 15 open reading frame 40	0.5064	59
PRPF6	Pre-mRNA processing factor 6	0.5063	52
TMBIM4	Transmembrane BAX inhibitor motif containing 4	0.4932	66
TRMT10A	TRNA methyltransferase 10A	0.4918	13
ATP5MF	ATP synthase membrane subunit f	0.4875	7
C11orf91	Chromosome 11 open reading frame 91	0.4805	66
NAPRT	Nicotinate phosphoribosyltransferase	0.4802	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	46.6 nTPM
Breast	50.2 nTPM
Adipose tissue	42.9 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	40.9 nTPM
Lung	40.9 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	37.7 nTPM
PBMC	52.9 nTPM
Stomach	46.7 nTPM
Spleen	46.4 nTPM
Bone marrow	44.9 nTPM
Adipose tissue	44.1 nTPM
Lymph node	34.5 nTPM
Liver	33.1 nTPM
Colon	31.9 nTPM
Kidney	23.8 nTPM
Breast	18.7 nTPM

Dendritic cells	43.6 nTPM
Adipose tissue	49.6 nTPM
Breast	41.2 nTPM
PBMC	39.8 nTPM

Endothelial cells	27.9 nTPM
Lung	46.8 nTPM
Testis	40.9 nTPM
Esophagus	40.6 nTPM
Breast	32.6 nTPM
Skeletal muscle	31.2 nTPM
Endometrium	28.1 nTPM
Prostate	27.7 nTPM
Heart muscle	26.6 nTPM
Eye	25.1 nTPM
Placenta	25.0 nTPM
Pancreas	23.1 nTPM
Liver	22.9 nTPM
Ovary	20.0 nTPM
Skin	0.0 nTPM

Fibroblasts	35.6 nTPM
Adipose tissue	64.0 nTPM
Esophagus	49.6 nTPM
Stomach	46.0 nTPM
Breast	44.1 nTPM
Placenta	39.3 nTPM
Prostate	37.3 nTPM
Skeletal muscle	31.9 nTPM
Ovary	31.4 nTPM
Lung	30.1 nTPM
Heart muscle	18.0 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	32.6 nTPM
Small intestine	35.6 nTPM
Rectum	33.7 nTPM
Colon	28.6 nTPM

Macrophages	34.7 nTPM
Kidney	46.8 nTPM
Esophagus	42.5 nTPM
Bone marrow	42.5 nTPM
Ovary	42.0 nTPM
Endometrium	39.6 nTPM
Pancreas	38.3 nTPM
Breast	38.2 nTPM
Prostate	37.9 nTPM
Lung	37.8 nTPM
Testis	35.5 nTPM
Adipose tissue	35.5 nTPM
Stomach	35.1 nTPM
Spleen	24.9 nTPM
Skeletal muscle	23.4 nTPM
PBMC	0.0 nTPM

Paneth cells	31.0 nTPM
Rectum	33.8 nTPM
Colon	32.9 nTPM
Small intestine	26.3 nTPM

Plasma cells	30.4 nTPM
Adipose tissue	39.4 nTPM
Spleen	35.0 nTPM
Esophagus	30.7 nTPM
Stomach	30.3 nTPM
Bone marrow	16.5 nTPM

Respiratory ciliated cells	27.0 nTPM
Lung	54.0 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	33.0 nTPM
Adipose tissue	58.9 nTPM
Esophagus	46.5 nTPM
Breast	45.7 nTPM
Prostate	45.6 nTPM
Skeletal muscle	41.5 nTPM
Pancreas	38.9 nTPM
Heart muscle	31.4 nTPM
Endometrium	28.3 nTPM
Ovary	25.9 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	37.8 nTPM
PBMC	55.0 nTPM
Prostate	52.1 nTPM
Spleen	47.3 nTPM
Kidney	47.2 nTPM
Lymph node	45.1 nTPM
Stomach	45.0 nTPM
Bone marrow	43.8 nTPM
Breast	40.7 nTPM
Adipose tissue	39.7 nTPM
Lung	39.5 nTPM
Endometrium	39.4 nTPM
Colon	37.6 nTPM
Liver	34.8 nTPM
Ovary	26.7 nTPM
Esophagus	26.2 nTPM
Skeletal muscle	22.1 nTPM
Skin	0.0 nTPM

Basal prostatic cells	51.6 nTPM
Prostate	51.6 nTPM

Basal squamous epithelial cells	51.2 nTPM
Esophagus	51.2 nTPM

Cholangiocytes	27.1 nTPM
Liver	27.1 nTPM

Collecting duct cells	38.6 nTPM
Kidney	38.6 nTPM

Undifferentiated cells	33.1 nTPM
Small intestine	40.5 nTPM
Rectum	30.6 nTPM
Colon	28.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC