Single cell type - NBPF1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NBPF1
Gene descriptionⁱ Full gene name according to HGNC.	NBPF member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Distal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Distal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NBPF1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HEATR5A	HEAT repeat containing 5A	0.6980	53
CLCN2	Chloride voltage-gated channel 2	0.6362	53
AHCYL2	Adenosylhomocysteinase like 2	0.6355	53
APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	0.6154	53
PLCD1	Phospholipase C delta 1	0.6135	53
OR2F1	Olfactory receptor family 2 subfamily F member 1	0.6114	53
ARRDC4	Arrestin domain containing 4	0.5904	53
SLC26A3	Solute carrier family 26 member 3	0.5829	53
SGK2	Serum/glucocorticoid regulated kinase 2	0.5687	53
SIPA1L3	Signal induced proliferation associated 1 like 3	0.5666	53
CLCA4	Chloride channel accessory 4	0.5626	53
MIER3	MIER family member 3	0.5614	53
MYO15B	Myosin XVB	0.5609	53
MS4A12	Membrane spanning 4-domains A12	0.5570	53
GPA33	Glycoprotein A33	0.5537	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.2 nTPM
Breast	7.3 nTPM
Adipose tissue	3.2 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	14.8 nTPM
Lung	14.8 nTPM

B-cells	5.7 nTPM
Bone marrow	12.3 nTPM
Spleen	11.1 nTPM
Colon	8.0 nTPM
Lymph node	7.3 nTPM
Stomach	6.4 nTPM
PBMC	4.3 nTPM
Breast	4.0 nTPM
Adipose tissue	3.0 nTPM
Liver	0.9 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	8.2 nTPM
Skin	8.2 nTPM

Dendritic cells	3.5 nTPM
Breast	6.5 nTPM
Adipose tissue	4.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	10.2 nTPM
Heart muscle	42.4 nTPM
Lung	18.7 nTPM
Skin	14.0 nTPM
Esophagus	8.3 nTPM
Ovary	7.9 nTPM
Breast	7.8 nTPM
Pancreas	7.7 nTPM
Endometrium	7.2 nTPM
Testis	5.9 nTPM
Placenta	5.7 nTPM
Liver	5.5 nTPM
Skeletal muscle	5.5 nTPM
Prostate	4.3 nTPM
Eye	1.6 nTPM

Fibroblasts	19.7 nTPM
Heart muscle	56.8 nTPM
Esophagus	32.9 nTPM
Skin	31.7 nTPM
Stomach	23.7 nTPM
Skeletal muscle	16.0 nTPM
Ovary	14.2 nTPM
Breast	13.3 nTPM
Placenta	10.4 nTPM
Adipose tissue	8.7 nTPM
Lung	6.7 nTPM
Prostate	2.6 nTPM

Intestinal goblet cells	25.4 nTPM
Colon	35.8 nTPM
Rectum	21.0 nTPM
Small intestine	19.3 nTPM

Macrophages	7.1 nTPM
Stomach	14.7 nTPM
Esophagus	14.2 nTPM
Lung	13.8 nTPM
Bone marrow	12.5 nTPM
Breast	8.6 nTPM
Spleen	8.3 nTPM
Ovary	8.0 nTPM
Skeletal muscle	5.7 nTPM
Testis	5.2 nTPM
Kidney	4.6 nTPM
Adipose tissue	4.0 nTPM
Prostate	3.4 nTPM
Endometrium	2.8 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	19.3 nTPM
Colon	36.2 nTPM
Rectum	14.3 nTPM
Small intestine	7.5 nTPM

Plasma cells	5.3 nTPM
Esophagus	12.3 nTPM
Stomach	6.9 nTPM
Adipose tissue	4.5 nTPM
Bone marrow	1.7 nTPM
Spleen	1.0 nTPM

Respiratory ciliated cells	15.5 nTPM
Bronchus	16.5 nTPM
Lung	14.6 nTPM

Smooth muscle cells	10.0 nTPM
Heart muscle	27.9 nTPM
Skin	18.4 nTPM
Esophagus	14.0 nTPM
Endometrium	9.7 nTPM
Breast	8.1 nTPM
Ovary	7.1 nTPM
Bronchus	6.6 nTPM
Pancreas	5.9 nTPM
Adipose tissue	5.9 nTPM
Skeletal muscle	4.1 nTPM
Prostate	2.5 nTPM

T-cells	4.0 nTPM
Skin	10.5 nTPM
Bone marrow	8.1 nTPM
Skeletal muscle	6.5 nTPM
Lymph node	5.9 nTPM
Spleen	5.9 nTPM
Breast	5.3 nTPM
Colon	5.2 nTPM
Stomach	4.9 nTPM
Adipose tissue	3.8 nTPM
Endometrium	3.4 nTPM
Lung	3.0 nTPM
PBMC	2.4 nTPM
Liver	2.2 nTPM
Kidney	1.4 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Astrocytes	73.8 nTPM
Brain	73.8 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Cytotrophoblasts	6.3 nTPM
Placenta	6.3 nTPM

Undifferentiated cells	15.2 nTPM
Colon	21.0 nTPM
Rectum	14.4 nTPM
Small intestine	10.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC