Single cell type - HSBP1L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSBP1L1
Gene descriptionⁱ Full gene name according to HGNC.	Heat shock factor binding protein 1 like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HHSteC, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HSBP1L1 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PROM2	Prominin 2	0.6810	26
SPINT2	Serine peptidase inhibitor, Kunitz type 2	0.6807	47
CNKSR1	Connector enhancer of kinase suppressor of Ras 1	0.6317	26
ARRDC1	Arrestin domain containing 1	0.6188	26
RHBDL2	Rhomboid like 2	0.6135	26
BIK	BCL2 interacting killer	0.6039	26
SSH3	Slingshot protein phosphatase 3	0.5997	30
PRSS22	Serine protease 22	0.5903	26
MED24	Mediator complex subunit 24	0.5868	26
SDR16C5	Short chain dehydrogenase/reductase family 16C member 5	0.5784	26
PI3	Peptidase inhibitor 3	0.5716	26
WFDC2	WAP four-disulfide core domain 2	0.5702	26
ITGB4	Integrin subunit beta 4	0.5687	26
SYNE4	Spectrin repeat containing nuclear envelope family member 4	0.5657	35
SLC6A14	Solute carrier family 6 member 14	0.5656	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.4 nTPM
Breast	49.7 nTPM
Adipose tissue	23.1 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	34.5 nTPM
Lung	34.5 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	5.0 nTPM
Breast	21.3 nTPM
Colon	4.8 nTPM
Lymph node	4.4 nTPM
PBMC	4.3 nTPM
Stomach	4.1 nTPM
Spleen	3.8 nTPM
Liver	3.7 nTPM
Adipose tissue	3.0 nTPM
Bone marrow	0.8 nTPM
Kidney	0.0 nTPM

Dendritic cells	9.6 nTPM
Breast	14.2 nTPM
Adipose tissue	10.5 nTPM
PBMC	4.0 nTPM

Endothelial cells	23.0 nTPM
Testis	44.8 nTPM
Skin	43.3 nTPM
Breast	39.9 nTPM
Liver	30.2 nTPM
Prostate	25.5 nTPM
Skeletal muscle	23.9 nTPM
Esophagus	22.7 nTPM
Endometrium	20.7 nTPM
Heart muscle	20.5 nTPM
Ovary	15.1 nTPM
Placenta	11.9 nTPM
Eye	8.9 nTPM
Pancreas	7.7 nTPM
Lung	6.2 nTPM

Fibroblasts	16.0 nTPM
Lung	35.7 nTPM
Skin	32.4 nTPM
Placenta	22.7 nTPM
Stomach	17.8 nTPM
Breast	13.6 nTPM
Prostate	12.4 nTPM
Esophagus	11.7 nTPM
Skeletal muscle	10.7 nTPM
Adipose tissue	7.1 nTPM
Ovary	5.9 nTPM
Heart muscle	5.8 nTPM

Intestinal goblet cells	81.3 nTPM
Rectum	90.2 nTPM
Colon	87.9 nTPM
Small intestine	65.7 nTPM

Macrophages	16.0 nTPM
Ovary	39.3 nTPM
Pancreas	35.7 nTPM
Prostate	29.8 nTPM
Testis	25.0 nTPM
Breast	21.5 nTPM
Endometrium	13.3 nTPM
Kidney	12.9 nTPM
Skeletal muscle	12.9 nTPM
Bone marrow	11.3 nTPM
Esophagus	11.0 nTPM
Adipose tissue	10.9 nTPM
Lung	8.1 nTPM
Spleen	5.2 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	99.6 nTPM
Colon	131.8 nTPM
Rectum	106.9 nTPM
Small intestine	60.1 nTPM

Plasma cells	2.3 nTPM
Stomach	5.3 nTPM
Adipose tissue	4.5 nTPM
Spleen	1.9 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	80.3 nTPM
Bronchus	109.6 nTPM
Lung	51.0 nTPM

Smooth muscle cells	15.9 nTPM
Bronchus	47.0 nTPM
Ovary	32.5 nTPM
Prostate	19.4 nTPM
Breast	15.4 nTPM
Skin	14.6 nTPM
Pancreas	13.4 nTPM
Endometrium	11.5 nTPM
Adipose tissue	8.5 nTPM
Esophagus	6.2 nTPM
Skeletal muscle	4.8 nTPM
Heart muscle	2.0 nTPM

T-cells	12.2 nTPM
Lymph node	33.1 nTPM
Kidney	19.1 nTPM
PBMC	19.0 nTPM
Skin	18.5 nTPM
Breast	16.1 nTPM
Endometrium	15.7 nTPM
Spleen	13.2 nTPM
Adipose tissue	13.1 nTPM
Colon	12.4 nTPM
Liver	10.0 nTPM
Skeletal muscle	9.7 nTPM
Prostate	9.5 nTPM
Bone marrow	7.5 nTPM
Lung	4.5 nTPM
Stomach	3.9 nTPM
Ovary	2.2 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	39.8 nTPM
Skin	39.8 nTPM

Basal prostatic cells	66.0 nTPM
Prostate	66.0 nTPM

Basal respiratory cells	135.5 nTPM
Bronchus	135.5 nTPM

Cholangiocytes	48.6 nTPM
Liver	48.6 nTPM

Undifferentiated cells	99.6 nTPM
Rectum	115.8 nTPM
Colon	108.9 nTPM
Small intestine	74.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC