Single cell type - NSUN6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NSUN6
Gene descriptionⁱ Full gene name according to HGNC.	NOP2/Sun RNA methyltransferase 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NSUN6 is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PPP1R10	Protein phosphatase 1 regulatory subunit 10	0.6164	7
IER2	Immediate early response 2	0.6042	7
INTS6	Integrator complex subunit 6	0.5437	7
YME1L1	YME1 like 1 ATPase	0.5261	7
SNAI1	Snail family transcriptional repressor 1	0.5215	7
TAZ	Tafazzin	0.5213	63
NXF1	Nuclear RNA export factor 1	0.5166	7
RSRP1	Arginine and serine rich protein 1	0.5120	7
KIF25	Kinesin family member 25	0.5025	14
FABP9	Fatty acid binding protein 9	0.5002	14
INPP5E	Inositol polyphosphate-5-phosphatase E	0.4968	7
KLHL15	Kelch like family member 15	0.4918	7
ZMYM5	Zinc finger MYM-type containing 5	0.4906	7
AC116366.1	Novel protein	0.4883	7
STPG3	Sperm-tail PG-rich repeat containing 3	0.4861	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	75.4 nTPM
Adipose tissue	79.8 nTPM
Breast	71.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	15.1 nTPM
Lung	15.1 nTPM

Astrocytes	57.8 nTPM
Brain	57.8 nTPM

B-cells	34.9 nTPM
Breast	69.6 nTPM
Lymph node	52.7 nTPM
Bone marrow	49.8 nTPM
Adipose tissue	38.6 nTPM
Liver	37.3 nTPM
Spleen	34.6 nTPM
PBMC	22.8 nTPM
Stomach	22.7 nTPM
Colon	11.2 nTPM
Kidney	9.5 nTPM

Dendritic cells	39.6 nTPM
Breast	68.1 nTPM
Adipose tissue	38.6 nTPM
PBMC	12.0 nTPM

Endothelial cells	37.5 nTPM
Skeletal muscle	85.4 nTPM
Skin	68.7 nTPM
Eye	66.3 nTPM
Esophagus	59.9 nTPM
Breast	59.6 nTPM
Testis	42.4 nTPM
Heart muscle	38.7 nTPM
Prostate	29.2 nTPM
Endometrium	28.4 nTPM
Liver	19.2 nTPM
Placenta	10.8 nTPM
Ovary	10.7 nTPM
Lung	6.2 nTPM
Pancreas	0.0 nTPM

Fibroblasts	19.2 nTPM
Lung	27.9 nTPM
Esophagus	26.9 nTPM
Breast	26.4 nTPM
Heart muscle	21.5 nTPM
Adipose tissue	20.5 nTPM
Skeletal muscle	17.8 nTPM
Stomach	16.3 nTPM
Ovary	15.9 nTPM
Skin	13.6 nTPM
Placenta	12.3 nTPM
Prostate	12.2 nTPM

Intestinal goblet cells	24.5 nTPM
Small intestine	35.1 nTPM
Colon	21.5 nTPM
Rectum	17.1 nTPM

Macrophages	28.5 nTPM
Breast	105.3 nTPM
Spleen	46.7 nTPM
Adipose tissue	41.8 nTPM
Endometrium	38.6 nTPM
Esophagus	34.6 nTPM
Testis	32.0 nTPM
Skeletal muscle	30.9 nTPM
Kidney	20.4 nTPM
Stomach	17.6 nTPM
PBMC	13.6 nTPM
Lung	11.3 nTPM
Bone marrow	11.3 nTPM
Pancreas	10.2 nTPM
Ovary	8.8 nTPM
Prostate	4.6 nTPM

Paneth cells	20.0 nTPM
Small intestine	26.3 nTPM
Colon	19.7 nTPM
Rectum	13.8 nTPM

Plasma cells	31.0 nTPM
Adipose tissue	48.3 nTPM
Spleen	39.7 nTPM
Bone marrow	29.7 nTPM
Stomach	25.2 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	14.5 nTPM
Lung	20.4 nTPM
Bronchus	8.6 nTPM

Smooth muscle cells	19.1 nTPM
Breast	39.6 nTPM
Skeletal muscle	32.2 nTPM
Adipose tissue	29.9 nTPM
Endometrium	28.6 nTPM
Esophagus	18.6 nTPM
Skin	15.3 nTPM
Ovary	14.7 nTPM
Heart muscle	12.3 nTPM
Prostate	9.1 nTPM
Pancreas	7.3 nTPM
Bronchus	2.8 nTPM

T-cells	31.0 nTPM
Breast	73.1 nTPM
Lymph node	61.0 nTPM
Spleen	46.2 nTPM
Endometrium	45.5 nTPM
Bone marrow	36.0 nTPM
Liver	33.3 nTPM
Lung	28.8 nTPM
Adipose tissue	26.6 nTPM
Skeletal muscle	26.2 nTPM
PBMC	25.2 nTPM
Kidney	24.0 nTPM
Skin	22.6 nTPM
Stomach	22.0 nTPM
Colon	20.5 nTPM
Ovary	13.4 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	28.7 nTPM
Skin	28.7 nTPM

Basal respiratory cells	11.0 nTPM
Bronchus	11.0 nTPM

Basal squamous epithelial cells	30.1 nTPM
Esophagus	30.1 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	18.7 nTPM
Small intestine	22.0 nTPM
Colon	18.5 nTPM
Rectum	15.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC