Single cell type - MTRNR2L8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MTRNR2L8
Gene descriptionⁱ Full gene name according to HGNC.	MT-RNR2 like 8
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, basophil, eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HeLa, Hep G2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at transcript level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MTRNR2L8 is part of cluster 54 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MTRNR2L12	MT-RNR2 like 12	0.9522	54
MTRNR2L5	MT-RNR2 like 5	0.9226	54
MTRNR2L3	MT-RNR2 like 3	0.9197	54
MTRNR2L4	MT-RNR2 like 4	0.9115	54
MTRNR2L10	MT-RNR2 like 10	0.9101	54
OR9Q2	Olfactory receptor family 9 subfamily Q member 2	0.9096	54
MTRNR2L13	MT-RNR2 like 13	0.9072	54
FLNC	Filamin C	0.9036	54
MT-CO2	Mitochondrially encoded cytochrome c oxidase II	0.9012	54
NMRK2	Nicotinamide riboside kinase 2	0.9007	54
MYBPC3	Myosin binding protein C3	0.9007	54
HSPB7	Heat shock protein family B (small) member 7	0.9003	54
FBXO40	F-box protein 40	0.8940	54
FGF21	Fibroblast growth factor 21	0.8898	54
MT-ND6	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	0.8894	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	649.6 nTPM
Breast	880.9 nTPM
Adipose tissue	418.3 nTPM

Alveolar cells type 1	830.1 nTPM
Lung	830.1 nTPM

Alveolar cells type 2	866.0 nTPM
Lung	866.0 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	131.5 nTPM
Breast	794.4 nTPM
Adipose tissue	339.4 nTPM
Liver	116.8 nTPM
Kidney	42.9 nTPM
PBMC	18.6 nTPM
Bone marrow	1.7 nTPM
Spleen	0.7 nTPM
Lymph node	0.6 nTPM
Colon	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	118.0 nTPM
Breast	198.2 nTPM
Adipose tissue	143.8 nTPM
PBMC	12.0 nTPM

Endothelial cells	1034.0 nTPM
Heart muscle	8338.5 nTPM
Skeletal muscle	3208.4 nTPM
Lung	998.1 nTPM
Skin	499.2 nTPM
Prostate	460.4 nTPM
Breast	399.2 nTPM
Endometrium	356.9 nTPM
Liver	78.9 nTPM
Ovary	59.6 nTPM
Testis	56.0 nTPM
Placenta	19.9 nTPM
Esophagus	1.0 nTPM
Eye	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	1450.7 nTPM
Heart muscle	9002.2 nTPM
Skeletal muscle	2350.9 nTPM
Lung	1689.0 nTPM
Skin	1223.1 nTPM
Breast	822.6 nTPM
Prostate	450.6 nTPM
Adipose tissue	378.5 nTPM
Ovary	29.8 nTPM
Placenta	10.2 nTPM
Esophagus	0.6 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	0.5 nTPM
Colon	0.7 nTPM
Rectum	0.7 nTPM
Small intestine	0.0 nTPM

Macrophages	420.6 nTPM
Skeletal muscle	2047.6 nTPM
Lung	1107.8 nTPM
Breast	976.1 nTPM
Prostate	820.8 nTPM
Adipose tissue	698.9 nTPM
Endometrium	304.8 nTPM
Kidney	99.9 nTPM
Ovary	99.6 nTPM
PBMC	95.5 nTPM
Testis	54.0 nTPM
Spleen	3.1 nTPM
Esophagus	1.6 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	92.0 nTPM
Adipose tissue	458.6 nTPM
Stomach	0.9 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	481.4 nTPM
Lung	944.5 nTPM
Bronchus	18.3 nTPM

Smooth muscle cells	1533.4 nTPM
Heart muscle	8069.5 nTPM
Skeletal muscle	3548.6 nTPM
Breast	2415.5 nTPM
Skin	1033.5 nTPM
Prostate	777.7 nTPM
Adipose tissue	595.6 nTPM
Endometrium	393.1 nTPM
Ovary	32.4 nTPM
Bronchus	2.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	370.6 nTPM
Skeletal muscle	2661.8 nTPM
Lung	1169.4 nTPM
Skin	679.7 nTPM
Prostate	516.0 nTPM
Breast	489.0 nTPM
Endometrium	302.3 nTPM
Adipose tissue	253.6 nTPM
Liver	112.0 nTPM
Kidney	73.2 nTPM
Ovary	26.7 nTPM
PBMC	12.5 nTPM
Spleen	1.5 nTPM
Lymph node	1.1 nTPM
Stomach	0.7 nTPM
Bone marrow	0.5 nTPM
Colon	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	471.7 nTPM
Skin	471.7 nTPM

Basal prostatic cells	1069.8 nTPM
Prostate	1069.8 nTPM

Basal respiratory cells	27.1 nTPM
Bronchus	27.1 nTPM

Basal squamous epithelial cells	1.2 nTPM
Esophagus	1.2 nTPM

Undifferentiated cells	0.5 nTPM
Rectum	0.9 nTPM
Small intestine	0.5 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC