Single cell type - MTRNR2L12 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MTRNR2L12
Gene descriptionⁱ Full gene name according to HGNC.	MT-RNR2 like 12
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HeLa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at transcript level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MTRNR2L12 is part of cluster 54 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MTRNR2L8	MT-RNR2 like 8	0.9522	54
FLNC	Filamin C	0.8682	54
MTRNR2L3	MT-RNR2 like 3	0.8667	54
MTRNR2L5	MT-RNR2 like 5	0.8573	54
MYBPC3	Myosin binding protein C3	0.8556	54
HSPB7	Heat shock protein family B (small) member 7	0.8544	54
FGF21	Fibroblast growth factor 21	0.8520	54
MT-CO2	Mitochondrially encoded cytochrome c oxidase II	0.8466	54
NMRK2	Nicotinamide riboside kinase 2	0.8452	54
FBXO40	F-box protein 40	0.8436	54
MYH7	Myosin heavy chain 7	0.8428	54
OR9Q2	Olfactory receptor family 9 subfamily Q member 2	0.8409	54
DIPK1C	Divergent protein kinase domain 1C	0.8404	54
MT-ND6	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	0.8403	54
LRRC10	Leucine rich repeat containing 10	0.8351	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1081.2 nTPM
Breast	1679.9 nTPM
Adipose tissue	482.5 nTPM

Alveolar cells type 1	2705.1 nTPM
Lung	2705.1 nTPM

Alveolar cells type 2	2934.5 nTPM
Lung	2934.5 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	291.8 nTPM
Breast	1968.6 nTPM
Adipose tissue	689.7 nTPM
Liver	133.3 nTPM
PBMC	58.6 nTPM
Kidney	38.1 nTPM
Lymph node	8.2 nTPM
Bone marrow	7.4 nTPM
Stomach	6.4 nTPM
Spleen	6.2 nTPM
Colon	1.6 nTPM

Dendritic cells	394.0 nTPM
Breast	721.6 nTPM
Adipose tissue	448.5 nTPM
PBMC	12.0 nTPM

Endothelial cells	1236.7 nTPM
Heart muscle	8875.2 nTPM
Skeletal muscle	3491.1 nTPM
Lung	2844.5 nTPM
Endometrium	883.4 nTPM
Breast	677.8 nTPM
Prostate	184.1 nTPM
Ovary	136.6 nTPM
Skin	94.8 nTPM
Liver	73.4 nTPM
Testis	33.7 nTPM
Placenta	13.7 nTPM
Pancreas	3.9 nTPM
Esophagus	2.1 nTPM
Eye	0.0 nTPM

Fibroblasts	1698.5 nTPM
Heart muscle	8450.4 nTPM
Lung	5017.8 nTPM
Skeletal muscle	2819.3 nTPM
Breast	1327.3 nTPM
Adipose tissue	426.6 nTPM
Skin	339.4 nTPM
Prostate	183.2 nTPM
Ovary	103.0 nTPM
Placenta	9.6 nTPM
Stomach	6.0 nTPM
Esophagus	0.8 nTPM

Glandular and luminal cells	1465.4 nTPM
Endometrium	1465.4 nTPM

Intestinal goblet cells	7.1 nTPM
Rectum	14.5 nTPM
Small intestine	4.8 nTPM
Colon	2.2 nTPM

Macrophages	633.1 nTPM
Lung	3255.9 nTPM
Skeletal muscle	2454.7 nTPM
Breast	1638.8 nTPM
Adipose tissue	862.3 nTPM
Endometrium	692.9 nTPM
Prostate	194.8 nTPM
Ovary	187.5 nTPM
Kidney	83.9 nTPM
PBMC	54.6 nTPM
Testis	47.7 nTPM
Spleen	7.2 nTPM
Stomach	5.9 nTPM
Bone marrow	5.0 nTPM
Esophagus	4.8 nTPM
Pancreas	0.0 nTPM

Paneth cells	8.4 nTPM
Rectum	14.4 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	213.1 nTPM
Adipose tissue	1045.6 nTPM
Stomach	6.9 nTPM
Esophagus	6.1 nTPM
Spleen	5.3 nTPM
Bone marrow	1.7 nTPM

Respiratory ciliated cells	1431.8 nTPM
Lung	2859.6 nTPM
Bronchus	4.0 nTPM

Smooth muscle cells	1520.5 nTPM
Heart muscle	8157.7 nTPM
Skeletal muscle	3528.3 nTPM
Breast	2562.7 nTPM
Endometrium	1076.8 nTPM
Adipose tissue	611.5 nTPM
Prostate	385.1 nTPM
Skin	266.8 nTPM
Ovary	127.6 nTPM
Bronchus	7.5 nTPM
Esophagus	1.5 nTPM
Pancreas	0.5 nTPM

Basal keratinocytes	112.5 nTPM
Skin	112.5 nTPM

Basal prostatic cells	420.7 nTPM
Prostate	420.7 nTPM

Basal respiratory cells	10.3 nTPM
Bronchus	10.3 nTPM

Basal squamous epithelial cells	3.4 nTPM
Esophagus	3.4 nTPM

T-cells	625.8 nTPM
Skeletal muscle	3723.0 nTPM
Lung	3720.8 nTPM
Breast	1037.2 nTPM
Endometrium	702.3 nTPM
Adipose tissue	565.4 nTPM
Skin	216.5 nTPM
Prostate	213.0 nTPM
Liver	185.4 nTPM
Ovary	122.4 nTPM
Kidney	77.4 nTPM
PBMC	43.7 nTPM
Lymph node	7.2 nTPM
Esophagus	6.6 nTPM
Stomach	6.4 nTPM
Spleen	5.8 nTPM
Bone marrow	3.7 nTPM
Colon	1.0 nTPM

Undifferentiated cells	5.2 nTPM
Rectum	13.1 nTPM
Small intestine	2.1 nTPM
Colon	0.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC