Single cell type - ORAI1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ORAI1
Gene descriptionⁱ Full gene name according to HGNC.	ORAI calcium release-activated calcium modulator 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (dendritic cells, NK-cells, Theca cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (NB-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (dendritic cells, NK-cells, Theca cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ORAI1 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TENT5C	Terminal nucleotidyltransferase 5C	0.6532	7
SHISAL2A	Shisa like 2A	0.6523	7
RUNX3	RUNX family transcription factor 3	0.6426	24
BICDL1	BICD family like cargo adaptor 1	0.6281	24
GPR174	G protein-coupled receptor 174	0.6218	7
CASP8	Caspase 8	0.6197	24
TGFB1	Transforming growth factor beta 1	0.6195	7
FYB1	FYN binding protein 1	0.6127	7
GZMK	Granzyme K	0.6009	24
PPP2R5C	Protein phosphatase 2 regulatory subunit B'gamma	0.5934	24
ZNF831	Zinc finger protein 831	0.5906	24
SLA	Src like adaptor	0.5870	24
GRK2	G protein-coupled receptor kinase 2	0.5820	7
RNF125	Ring finger protein 125	0.5752	24
CNOT6L	CCR4-NOT transcription complex subunit 6 like	0.5733	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.0 nTPM
Breast	45.7 nTPM
Adipose tissue	18.4 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	16.4 nTPM
Lung	16.4 nTPM

Astrocytes	1.0 nTPM
Brain	1.0 nTPM

B-cells	41.0 nTPM
Adipose tissue	135.8 nTPM
PBMC	48.5 nTPM
Kidney	42.9 nTPM
Breast	40.2 nTPM
Stomach	34.9 nTPM
Colon	27.1 nTPM
Spleen	23.9 nTPM
Liver	22.4 nTPM
Bone marrow	18.0 nTPM
Lymph node	16.6 nTPM

Dendritic cells	92.3 nTPM
Adipose tissue	157.8 nTPM
Breast	111.2 nTPM
PBMC	8.0 nTPM

Endothelial cells	40.6 nTPM
Testis	86.8 nTPM
Ovary	60.9 nTPM
Prostate	52.2 nTPM
Endometrium	47.5 nTPM
Placenta	46.6 nTPM
Liver	44.9 nTPM
Esophagus	43.4 nTPM
Breast	43.4 nTPM
Eye	41.2 nTPM
Skin	39.8 nTPM
Skeletal muscle	26.3 nTPM
Pancreas	23.1 nTPM
Heart muscle	8.8 nTPM
Lung	3.1 nTPM

Fibroblasts	9.5 nTPM
Ovary	21.2 nTPM
Breast	18.8 nTPM
Placenta	16.4 nTPM
Skin	10.5 nTPM
Prostate	10.1 nTPM
Adipose tissue	8.1 nTPM
Stomach	7.4 nTPM
Skeletal muscle	5.9 nTPM
Esophagus	3.7 nTPM
Heart muscle	1.4 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	9.3 nTPM
Rectum	12.1 nTPM
Small intestine	11.4 nTPM
Colon	4.3 nTPM

Macrophages	42.8 nTPM
PBMC	177.3 nTPM
Ovary	52.9 nTPM
Breast	49.8 nTPM
Prostate	42.3 nTPM
Skeletal muscle	39.4 nTPM
Pancreas	38.3 nTPM
Adipose tissue	33.7 nTPM
Lung	32.9 nTPM
Kidney	32.5 nTPM
Spleen	31.1 nTPM
Bone marrow	28.7 nTPM
Endometrium	26.3 nTPM
Testis	26.1 nTPM
Esophagus	15.8 nTPM
Stomach	14.7 nTPM

Paneth cells	6.3 nTPM
Rectum	11.3 nTPM
Small intestine	7.5 nTPM
Colon	0.0 nTPM

Plasma cells	30.5 nTPM
Adipose tissue	93.5 nTPM
Bone marrow	33.0 nTPM
Spleen	15.2 nTPM
Stomach	10.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	6.3 nTPM
Lung	8.7 nTPM
Bronchus	3.9 nTPM

Smooth muscle cells	10.8 nTPM
Ovary	22.7 nTPM
Prostate	19.1 nTPM
Pancreas	18.3 nTPM
Bronchus	17.1 nTPM
Breast	11.0 nTPM
Endometrium	10.0 nTPM
Skin	5.2 nTPM
Skeletal muscle	5.0 nTPM
Heart muscle	3.6 nTPM
Adipose tissue	3.4 nTPM
Esophagus	3.1 nTPM

T-cells	70.3 nTPM
Adipose tissue	192.1 nTPM
Prostate	113.7 nTPM
Ovary	111.2 nTPM
Breast	99.3 nTPM
Kidney	85.6 nTPM
Colon	76.1 nTPM
Skeletal muscle	75.1 nTPM
PBMC	71.7 nTPM
Skin	67.7 nTPM
Spleen	65.4 nTPM
Bone marrow	58.9 nTPM
Stomach	50.0 nTPM
Liver	45.3 nTPM
Endometrium	38.0 nTPM
Lymph node	24.0 nTPM
Lung	15.2 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	22.6 nTPM
Skin	22.6 nTPM

Basal squamous epithelial cells	6.8 nTPM
Esophagus	6.8 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Undifferentiated cells	20.1 nTPM
Small intestine	22.4 nTPM
Colon	19.0 nTPM
Rectum	18.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC