Single cell type - BAIAP2L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BAIAP2L1
Gene descriptionⁱ Full gene name according to HGNC.	BAR/IMD domain containing adaptor protein 2 like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Prostatic glandular cells, Gastric mucus-secreting cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Prostatic glandular cells, Gastric mucus-secreting cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BAIAP2L1 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C3orf52	Chromosome 3 open reading frame 52	0.6275	22
SOWAHB	Sosondowah ankyrin repeat domain family member B	0.6272	22
HEBP2	Heme binding protein 2	0.5933	22
PLEKHN1	Pleckstrin homology domain containing N1	0.5901	22
MAL2	Mal, T cell differentiation protein 2	0.5880	22
C1orf116	Chromosome 1 open reading frame 116	0.5782	22
OCLN	Occludin	0.5730	22
AP3D1	Adaptor related protein complex 3 subunit delta 1	0.5708	53
FA2H	Fatty acid 2-hydroxylase	0.5698	22
SH2D3A	SH2 domain containing 3A	0.5693	22
JUP	Junction plakoglobin	0.5568	22
CHMP2B	Charged multivesicular body protein 2B	0.5503	53
CLDN4	Claudin 4	0.5416	22
TXNRD1	Thioredoxin reductase 1	0.5387	22
GPRC5A	G protein-coupled receptor class C group 5 member A	0.5343	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.9 nTPM
Adipose tissue	19.3 nTPM
Breast	14.6 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	22.9 nTPM
Lung	22.9 nTPM

Astrocytes	23.5 nTPM
Brain	23.5 nTPM

B-cells	0.8 nTPM
Colon	4.8 nTPM
Spleen	1.7 nTPM
Lymph node	1.1 nTPM
Adipose tissue	0.5 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	5.5 nTPM
PBMC	16.0 nTPM
Breast	0.4 nTPM
Adipose tissue	0.3 nTPM

Endothelial cells	11.2 nTPM
Skeletal muscle	26.0 nTPM
Testis	25.5 nTPM
Prostate	20.8 nTPM
Heart muscle	16.4 nTPM
Breast	13.2 nTPM
Eye	12.2 nTPM
Esophagus	10.3 nTPM
Skin	7.1 nTPM
Endometrium	6.7 nTPM
Lung	6.2 nTPM
Ovary	6.2 nTPM
Placenta	5.7 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	2.2 nTPM
Prostate	7.2 nTPM
Lung	5.6 nTPM
Placenta	5.3 nTPM
Heart muscle	2.3 nTPM
Breast	0.9 nTPM
Skin	0.8 nTPM
Skeletal muscle	0.6 nTPM
Ovary	0.6 nTPM
Esophagus	0.4 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	53.6 nTPM
Colon	60.8 nTPM
Small intestine	54.7 nTPM
Rectum	45.3 nTPM

Macrophages	1.0 nTPM
Prostate	4.6 nTPM
Endometrium	2.8 nTPM
Lung	2.6 nTPM
Testis	1.2 nTPM
Breast	1.1 nTPM
Kidney	0.8 nTPM
Skeletal muscle	0.6 nTPM
Adipose tissue	0.5 nTPM
Ovary	0.1 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	84.7 nTPM
Colon	204.2 nTPM
Rectum	35.1 nTPM
Small intestine	15.0 nTPM

Plasma cells	0.6 nTPM
Stomach	3.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	58.6 nTPM
Bronchus	76.4 nTPM
Lung	40.8 nTPM

Smooth muscle cells	6.7 nTPM
Bronchus	23.5 nTPM
Prostate	13.8 nTPM
Skin	8.7 nTPM
Endometrium	7.6 nTPM
Pancreas	5.0 nTPM
Esophagus	3.1 nTPM
Heart muscle	3.0 nTPM
Breast	2.4 nTPM
Adipose tissue	2.3 nTPM
Skeletal muscle	2.1 nTPM
Ovary	1.9 nTPM

T-cells	1.9 nTPM
Esophagus	6.6 nTPM
Prostate	4.7 nTPM
Colon	3.8 nTPM
Kidney	3.4 nTPM
Endometrium	3.3 nTPM
Ovary	2.2 nTPM
Skeletal muscle	1.5 nTPM
Breast	1.5 nTPM
Stomach	1.3 nTPM
Adipose tissue	1.2 nTPM
Bone marrow	0.8 nTPM
Liver	0.5 nTPM
PBMC	0.5 nTPM
Skin	0.5 nTPM
Lymph node	0.5 nTPM
Spleen	0.5 nTPM
Lung	0.0 nTPM

Basal keratinocytes	16.7 nTPM
Skin	16.7 nTPM

Basal prostatic cells	64.8 nTPM
Prostate	64.8 nTPM

Basal respiratory cells	31.5 nTPM
Bronchus	31.5 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Undifferentiated cells	44.7 nTPM
Colon	70.1 nTPM
Rectum	35.1 nTPM
Small intestine	28.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC