Single cell type - CHMP2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CHMP2B
Gene descriptionⁱ Full gene name according to HGNC.	Charged multivesicular body protein 2B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CHMP2B is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CRB3	Crumbs cell polarity complex component 3	0.7404	53
CEACAM1	CEA cell adhesion molecule 1	0.6923	53
KRTAP13-2	Keratin associated protein 13-2	0.6665	53
SPATS2L	Spermatogenesis associated serine rich 2 like	0.6533	53
GPRC5A	G protein-coupled receptor class C group 5 member A	0.6531	22
PPARD	Peroxisome proliferator activated receptor delta	0.6466	53
HIGD1A	HIG1 hypoxia inducible domain family member 1A	0.6435	53
TMBIM1	Transmembrane BAX inhibitor motif containing 1	0.6272	53
LRP10	LDL receptor related protein 10	0.6217	53
TXNRD1	Thioredoxin reductase 1	0.6210	22
TNFRSF21	TNF receptor superfamily member 21	0.6203	22
PPP2CB	Protein phosphatase 2 catalytic subunit beta	0.6199	53
ANXA11	Annexin A11	0.6172	53
MAL2	Mal, T cell differentiation protein 2	0.6135	22
RHOC	Ras homolog family member C	0.6131	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	56.2 nTPM
Adipose tissue	66.0 nTPM
Breast	46.3 nTPM

Alveolar cells type 1	83.3 nTPM
Lung	83.3 nTPM

Alveolar cells type 2	68.7 nTPM
Lung	68.7 nTPM

Astrocytes	11.4 nTPM
Brain	11.4 nTPM

B-cells	58.7 nTPM
Adipose tissue	101.3 nTPM
Colon	87.9 nTPM
Stomach	74.5 nTPM
Kidney	61.9 nTPM
PBMC	58.6 nTPM
Spleen	48.8 nTPM
Lymph node	47.6 nTPM
Breast	36.0 nTPM
Liver	35.1 nTPM
Bone marrow	35.1 nTPM

Dendritic cells	45.7 nTPM
Adipose tissue	60.3 nTPM
PBMC	43.8 nTPM
Breast	33.2 nTPM

Endothelial cells	54.4 nTPM
Prostate	111.4 nTPM
Lung	81.1 nTPM
Testis	63.4 nTPM
Skin	61.0 nTPM
Skeletal muscle	59.2 nTPM
Endometrium	49.1 nTPM
Eye	48.6 nTPM
Liver	46.7 nTPM
Placenta	45.5 nTPM
Breast	44.5 nTPM
Esophagus	43.3 nTPM
Pancreas	38.6 nTPM
Ovary	38.4 nTPM
Heart muscle	30.9 nTPM

Fibroblasts	68.9 nTPM
Prostate	162.1 nTPM
Adipose tissue	90.2 nTPM
Skin	76.1 nTPM
Lung	74.8 nTPM
Heart muscle	62.9 nTPM
Skeletal muscle	61.4 nTPM
Stomach	53.4 nTPM
Breast	50.5 nTPM
Esophagus	49.7 nTPM
Placenta	48.3 nTPM
Ovary	28.5 nTPM

Intestinal goblet cells	80.3 nTPM
Colon	112.2 nTPM
Rectum	77.0 nTPM
Small intestine	51.7 nTPM

Macrophages	72.6 nTPM
Adipose tissue	126.9 nTPM
Pancreas	114.9 nTPM
Lung	108.7 nTPM
Prostate	83.7 nTPM
Ovary	83.3 nTPM
Testis	79.6 nTPM
Kidney	74.8 nTPM
Endometrium	67.0 nTPM
Skeletal muscle	66.5 nTPM
Spleen	60.2 nTPM
Stomach	58.6 nTPM
Esophagus	55.1 nTPM
Breast	50.6 nTPM
Bone marrow	46.2 nTPM
PBMC	13.6 nTPM

Paneth cells	241.3 nTPM
Colon	454.5 nTPM
Rectum	153.0 nTPM
Small intestine	116.4 nTPM

Plasma cells	30.0 nTPM
Stomach	42.4 nTPM
Adipose tissue	32.2 nTPM
Spleen	27.7 nTPM
Esophagus	24.6 nTPM
Bone marrow	23.0 nTPM

Respiratory ciliated cells	90.5 nTPM
Lung	103.5 nTPM
Bronchus	77.5 nTPM

Smooth muscle cells	57.5 nTPM
Prostate	114.7 nTPM
Adipose tissue	65.9 nTPM
Skin	65.2 nTPM
Skeletal muscle	58.2 nTPM
Pancreas	56.6 nTPM
Breast	56.4 nTPM
Ovary	47.8 nTPM
Endometrium	44.4 nTPM
Esophagus	43.4 nTPM
Bronchus	43.2 nTPM
Heart muscle	36.9 nTPM

T-cells	52.9 nTPM
Prostate	94.7 nTPM
Adipose tissue	79.1 nTPM
Colon	66.6 nTPM
Skin	61.7 nTPM
Lung	60.7 nTPM
Ovary	55.6 nTPM
Esophagus	52.4 nTPM
Endometrium	51.8 nTPM
Stomach	50.1 nTPM
Kidney	48.6 nTPM
PBMC	46.4 nTPM
Breast	43.3 nTPM
Liver	41.8 nTPM
Skeletal muscle	40.8 nTPM
Spleen	38.0 nTPM
Lymph node	34.9 nTPM
Bone marrow	32.0 nTPM

Basal keratinocytes	132.0 nTPM
Skin	132.0 nTPM

Basal prostatic cells	254.5 nTPM
Prostate	254.5 nTPM

Basal respiratory cells	90.0 nTPM
Bronchus	90.0 nTPM

Cone photoreceptor cells	4.2 nTPM
Eye	4.2 nTPM

Undifferentiated cells	81.3 nTPM
Colon	113.1 nTPM
Rectum	71.0 nTPM
Small intestine	59.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC