Single cell type - TRAPPC6A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRAPPC6A
Gene descriptionⁱ Full gene name according to HGNC.	Trafficking protein particle complex 6A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRAPPC6A is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase	0.6882	67
GLOD4	Glyoxalase domain containing 4	0.6107	39
MT1G	Metallothionein 1G	0.6085	67
MT1H	Metallothionein 1H	0.5846	67
MT1F	Metallothionein 1F	0.5774	67
HSD17B8	Hydroxysteroid 17-beta dehydrogenase 8	0.5738	67
XAB2	XPA binding protein 2	0.5719	67
CLYBL	Citramalyl-CoA lyase	0.5689	67
MACROD1	Mono-ADP ribosylhydrolase 1	0.5643	67
HINT2	Histidine triad nucleotide binding protein 2	0.5628	39
SDHC	Succinate dehydrogenase complex subunit C	0.5572	67
RABGGTB	Rab geranylgeranyltransferase subunit beta	0.5564	67
ACAD8	Acyl-CoA dehydrogenase family member 8	0.5552	39
PRDX3	Peroxiredoxin 3	0.5544	39
SLC2A9	Solute carrier family 2 member 9	0.5521	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	28.8 nTPM
Breast	31.6 nTPM
Adipose tissue	25.9 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	51.7 nTPM
Lung	51.7 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	61.6 nTPM
Kidney	104.8 nTPM
Spleen	64.4 nTPM
Breast	64.1 nTPM
Colon	62.3 nTPM
Stomach	60.0 nTPM
Bone marrow	55.6 nTPM
Lymph node	53.5 nTPM
Adipose tissue	52.1 nTPM
PBMC	49.9 nTPM
Liver	49.2 nTPM

Dendritic cells	63.4 nTPM
Breast	77.6 nTPM
Adipose tissue	60.8 nTPM
PBMC	51.8 nTPM

Endothelial cells	33.7 nTPM
Skin	62.2 nTPM
Liver	59.6 nTPM
Placenta	55.2 nTPM
Breast	41.1 nTPM
Lung	34.3 nTPM
Ovary	30.9 nTPM
Skeletal muscle	30.2 nTPM
Heart muscle	30.1 nTPM
Testis	29.3 nTPM
Esophagus	29.1 nTPM
Endometrium	23.7 nTPM
Prostate	22.6 nTPM
Eye	12.2 nTPM
Pancreas	11.6 nTPM

Fibroblasts	24.8 nTPM
Placenta	47.6 nTPM
Ovary	32.7 nTPM
Skin	29.0 nTPM
Adipose tissue	28.7 nTPM
Lung	25.7 nTPM
Breast	24.4 nTPM
Heart muscle	19.7 nTPM
Skeletal muscle	19.3 nTPM
Stomach	19.3 nTPM
Esophagus	19.2 nTPM
Prostate	7.2 nTPM

Intestinal goblet cells	84.6 nTPM
Colon	101.5 nTPM
Rectum	93.2 nTPM
Small intestine	59.1 nTPM

Macrophages	45.3 nTPM
Kidney	99.9 nTPM
Ovary	62.3 nTPM
Adipose tissue	58.8 nTPM
Breast	56.1 nTPM
Prostate	52.7 nTPM
Pancreas	51.0 nTPM
Lung	44.9 nTPM
Endometrium	41.3 nTPM
Skeletal muscle	34.6 nTPM
Testis	34.3 nTPM
Spleen	31.1 nTPM
Esophagus	29.9 nTPM
Bone marrow	28.7 nTPM
PBMC	27.3 nTPM
Stomach	26.4 nTPM

Paneth cells	73.8 nTPM
Rectum	95.8 nTPM
Small intestine	82.6 nTPM
Colon	42.8 nTPM

Plasma cells	39.9 nTPM
Stomach	53.0 nTPM
Esophagus	49.4 nTPM
Bone marrow	34.6 nTPM
Adipose tissue	32.2 nTPM
Spleen	30.2 nTPM

Respiratory ciliated cells	62.0 nTPM
Bronchus	86.2 nTPM
Lung	37.9 nTPM

Smooth muscle cells	34.4 nTPM
Bronchus	113.8 nTPM
Ovary	39.0 nTPM
Skin	35.9 nTPM
Breast	35.4 nTPM
Skeletal muscle	29.9 nTPM
Heart muscle	28.3 nTPM
Adipose tissue	28.2 nTPM
Prostate	22.6 nTPM
Esophagus	18.6 nTPM
Endometrium	17.6 nTPM
Pancreas	9.1 nTPM

T-cells	72.1 nTPM
Kidney	121.2 nTPM
Liver	98.6 nTPM
Ovary	95.6 nTPM
Skin	87.5 nTPM
Adipose tissue	84.1 nTPM
Spleen	78.9 nTPM
Lymph node	71.4 nTPM
Breast	70.8 nTPM
PBMC	70.4 nTPM
Bone marrow	68.7 nTPM
Stomach	67.3 nTPM
Colon	67.0 nTPM
Lung	66.8 nTPM
Esophagus	58.9 nTPM
Skeletal muscle	51.7 nTPM
Endometrium	48.1 nTPM
Prostate	19.0 nTPM

Basal keratinocytes	58.1 nTPM
Skin	58.1 nTPM

Basal prostatic cells	64.3 nTPM
Prostate	64.3 nTPM

Basal respiratory cells	149.3 nTPM
Bronchus	149.3 nTPM

Cholangiocytes	68.6 nTPM
Liver	68.6 nTPM

Undifferentiated cells	81.8 nTPM
Rectum	94.3 nTPM
Colon	79.4 nTPM
Small intestine	71.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC