Single cell type - UQCRC1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UQCRC1
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquinol-cytochrome c reductase core protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UQCRC1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFV1	NADH:ubiquinone oxidoreductase core subunit V1	0.7631	39
CYC1	Cytochrome c1	0.6736	39
NDUFS6	NADH:ubiquinone oxidoreductase subunit S6	0.6731	39
NDUFS8	NADH:ubiquinone oxidoreductase core subunit S8	0.6663	39
MRPL12	Mitochondrial ribosomal protein L12	0.6504	53
IDH3B	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	0.6497	39
NDUFB10	NADH:ubiquinone oxidoreductase subunit B10	0.6434	39
MRPL21	Mitochondrial ribosomal protein L21	0.6380	39
NDUFS7	NADH:ubiquinone oxidoreductase core subunit S7	0.6359	39
NDUFB7	NADH:ubiquinone oxidoreductase subunit B7	0.6278	53
APEH	Acylaminoacyl-peptide hydrolase	0.6027	53
MPND	MPN domain containing	0.6018	53
IDH3G	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	0.5958	39
ADAP1	ArfGAP with dual PH domains 1	0.5938	53
CDX1	Caudal type homeobox 1	0.5925	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.5 nTPM
Adipose tissue	32.8 nTPM
Breast	30.2 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	50.4 nTPM
Lung	50.4 nTPM

Astrocytes	17.3 nTPM
Brain	17.3 nTPM

B-cells	59.0 nTPM
Liver	148.1 nTPM
Kidney	76.1 nTPM
Spleen	69.9 nTPM
Stomach	65.9 nTPM
Colon	51.1 nTPM
Bone marrow	45.8 nTPM
PBMC	40.0 nTPM
Lymph node	37.9 nTPM
Breast	36.0 nTPM
Adipose tissue	19.1 nTPM

Basal squamous epithelial cells	103.6 nTPM
Esophagus	103.6 nTPM

Dendritic cells	28.0 nTPM
Adipose tissue	32.2 nTPM
Breast	27.7 nTPM
PBMC	23.9 nTPM

Endothelial cells	53.4 nTPM
Heart muscle	102.9 nTPM
Placenta	87.5 nTPM
Pancreas	84.9 nTPM
Ovary	60.7 nTPM
Skin	50.6 nTPM
Breast	46.3 nTPM
Eye	46.1 nTPM
Lung	43.7 nTPM
Testis	42.9 nTPM
Prostate	40.7 nTPM
Liver	38.5 nTPM
Skeletal muscle	35.1 nTPM
Esophagus	33.9 nTPM
Endometrium	33.5 nTPM

Enteroendocrine cells	144.5 nTPM
Rectum	150.5 nTPM
Colon	138.6 nTPM

Fibroblasts	78.2 nTPM
Heart muscle	214.5 nTPM
Ovary	127.4 nTPM
Placenta	126.9 nTPM
Skin	66.9 nTPM
Esophagus	63.4 nTPM
Stomach	57.9 nTPM
Adipose tissue	52.5 nTPM
Prostate	45.4 nTPM
Breast	42.8 nTPM
Skeletal muscle	37.3 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	319.6 nTPM
Colon	491.0 nTPM
Rectum	256.3 nTPM
Small intestine	211.5 nTPM

Macrophages	107.7 nTPM
Pancreas	298.6 nTPM
Kidney	174.7 nTPM
Stomach	167.0 nTPM
Spleen	143.1 nTPM
Bone marrow	136.2 nTPM
Prostate	103.1 nTPM
Testis	91.8 nTPM
Lung	88.7 nTPM
Adipose tissue	86.5 nTPM
Ovary	81.2 nTPM
Skeletal muscle	70.2 nTPM
Endometrium	61.5 nTPM
Esophagus	59.8 nTPM
Breast	38.9 nTPM
PBMC	13.6 nTPM

Paneth cells	333.3 nTPM
Colon	454.5 nTPM
Rectum	275.1 nTPM
Small intestine	270.3 nTPM

Plasma cells	117.6 nTPM
Spleen	236.9 nTPM
Bone marrow	153.3 nTPM
Stomach	113.9 nTPM
Esophagus	43.0 nTPM
Adipose tissue	40.7 nTPM

Respiratory ciliated cells	104.7 nTPM
Bronchus	123.5 nTPM
Lung	86.0 nTPM

Cholangiocytes	140.2 nTPM
Liver	140.2 nTPM

Collecting duct cells	121.4 nTPM
Kidney	121.4 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Cytotrophoblasts	334.4 nTPM
Placenta	334.4 nTPM

Smooth muscle cells	153.0 nTPM
Bronchus	674.2 nTPM
Pancreas	270.0 nTPM
Heart muscle	144.4 nTPM
Prostate	104.4 nTPM
Esophagus	103.9 nTPM
Skin	93.8 nTPM
Ovary	79.7 nTPM
Skeletal muscle	60.4 nTPM
Endometrium	54.8 nTPM
Adipose tissue	51.9 nTPM
Breast	45.2 nTPM

T-cells	50.8 nTPM
Kidney	84.2 nTPM
Colon	71.7 nTPM
Stomach	69.0 nTPM
Bone marrow	65.5 nTPM
Skin	65.4 nTPM
Liver	64.4 nTPM
Spleen	62.6 nTPM
Lung	59.2 nTPM
Ovary	48.9 nTPM
PBMC	48.2 nTPM
Esophagus	45.9 nTPM
Lymph node	40.0 nTPM
Endometrium	32.6 nTPM
Adipose tissue	29.9 nTPM
Breast	26.8 nTPM
Skeletal muscle	25.9 nTPM
Prostate	23.6 nTPM

Undifferentiated cells	416.8 nTPM
Colon	574.4 nTPM
Rectum	349.2 nTPM
Small intestine	326.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC