Single cell type - ALG13 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALG13
Gene descriptionⁱ Full gene name according to HGNC.	ALG13 UDP-N-acetylglucosaminyltransferase subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ALG13 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RHOH	Ras homolog family member H	0.6310	24
RLF	RLF zinc finger	0.6105	44
ELF1	E74 like ETS transcription factor 1	0.5907	24
MAPK1IP1L	Mitogen-activated protein kinase 1 interacting protein 1 like	0.5858	24
GTF2B	General transcription factor IIB	0.5798	7
ZNF331	Zinc finger protein 331	0.5791	7
BCAS2	BCAS2 pre-mRNA processing factor	0.5633	7
P2RY10	P2Y receptor family member 10	0.5581	24
TSC22D3	TSC22 domain family member 3	0.5565	24
TRAF3	TNF receptor associated factor 3	0.5500	21
CXCR4	C-X-C motif chemokine receptor 4	0.5486	24
RBM8A	RNA binding motif protein 8A	0.5436	39
PHTF2	Putative homeodomain transcription factor 2	0.5373	24
BTG1	BTG anti-proliferation factor 1	0.5344	24
IDS	Iduronate 2-sulfatase	0.5305	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.9 nTPM
Adipose tissue	56.0 nTPM
Breast	45.7 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	30.8 nTPM
Lung	30.8 nTPM

Astrocytes	33.6 nTPM
Brain	33.6 nTPM

B-cells	127.9 nTPM
Adipose tissue	345.8 nTPM
Stomach	263.9 nTPM
Colon	191.7 nTPM
Spleen	144.4 nTPM
Breast	108.2 nTPM
Lymph node	85.7 nTPM
Liver	49.6 nTPM
Bone marrow	44.9 nTPM
PBMC	25.7 nTPM
Kidney	19.0 nTPM

Dendritic cells	73.9 nTPM
Adipose tissue	95.8 nTPM
Breast	82.0 nTPM
PBMC	43.8 nTPM

Endothelial cells	37.4 nTPM
Heart muscle	54.9 nTPM
Prostate	47.9 nTPM
Skeletal muscle	43.8 nTPM
Lung	43.7 nTPM
Skin	42.3 nTPM
Testis	35.9 nTPM
Pancreas	34.7 nTPM
Liver	33.9 nTPM
Eye	33.2 nTPM
Breast	32.1 nTPM
Ovary	31.2 nTPM
Esophagus	31.0 nTPM
Endometrium	30.4 nTPM
Placenta	29.0 nTPM

Fibroblasts	34.6 nTPM
Adipose tissue	51.8 nTPM
Stomach	46.0 nTPM
Lung	44.6 nTPM
Prostate	41.6 nTPM
Skeletal muscle	40.6 nTPM
Breast	38.1 nTPM
Heart muscle	31.1 nTPM
Skin	27.8 nTPM
Esophagus	23.5 nTPM
Placenta	19.2 nTPM
Ovary	16.9 nTPM

Intestinal goblet cells	49.0 nTPM
Colon	57.9 nTPM
Rectum	50.1 nTPM
Small intestine	38.9 nTPM

Macrophages	56.1 nTPM
Adipose tissue	109.0 nTPM
Breast	93.8 nTPM
Skeletal muscle	77.5 nTPM
Pancreas	63.8 nTPM
Endometrium	61.5 nTPM
Stomach	61.5 nTPM
Prostate	53.9 nTPM
Spleen	51.8 nTPM
Ovary	42.9 nTPM
Testis	41.8 nTPM
Kidney	41.5 nTPM
Esophagus	40.9 nTPM
Bone marrow	37.5 nTPM
Lung	36.7 nTPM
PBMC	27.3 nTPM

Paneth cells	55.6 nTPM
Small intestine	75.1 nTPM
Colon	46.1 nTPM
Rectum	45.5 nTPM

Plasma cells	60.4 nTPM
Stomach	101.2 nTPM
Adipose tissue	68.3 nTPM
Spleen	48.1 nTPM
Esophagus	43.0 nTPM
Bone marrow	41.2 nTPM

Respiratory ciliated cells	35.3 nTPM
Lung	37.9 nTPM
Bronchus	32.7 nTPM

Smooth muscle cells	46.2 nTPM
Skin	165.1 nTPM
Prostate	45.6 nTPM
Skeletal muscle	45.4 nTPM
Adipose tissue	44.6 nTPM
Heart muscle	43.0 nTPM
Breast	34.1 nTPM
Pancreas	32.4 nTPM
Esophagus	29.4 nTPM
Ovary	25.6 nTPM
Endometrium	24.6 nTPM
Bronchus	18.7 nTPM

T-cells	71.1 nTPM
Breast	142.9 nTPM
Adipose tissue	128.2 nTPM
Prostate	108.9 nTPM
Colon	105.9 nTPM
Stomach	104.9 nTPM
Spleen	104.4 nTPM
Lymph node	75.8 nTPM
Ovary	73.4 nTPM
Endometrium	63.7 nTPM
Skin	63.0 nTPM
Skeletal muscle	56.9 nTPM
Lung	36.5 nTPM
Bone marrow	35.8 nTPM
Liver	35.2 nTPM
PBMC	33.3 nTPM
Kidney	27.4 nTPM
Esophagus	13.1 nTPM

Basal prostatic cells	65.8 nTPM
Prostate	65.8 nTPM

Basal respiratory cells	53.5 nTPM
Bronchus	53.5 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Undifferentiated cells	32.8 nTPM
Rectum	38.5 nTPM
Colon	31.7 nTPM
Small intestine	28.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC