Single cell type - PI4K2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PI4K2B
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol 4-kinase type 2 beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PI4K2B is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CISD2	CDGSH iron sulfur domain 2	0.4966	6
CAT	Catalase	0.4637	6
GOLPH3	Golgi phosphoprotein 3	0.4630	55
METTL7A	Methyltransferase like 7A	0.4507	15
CCS	Copper chaperone for superoxide dismutase	0.4425	6
PCBP1	Poly(rC) binding protein 1	0.4370	10
PDSS2	Decaprenyl diphosphate synthase subunit 2	0.4328	42
ABCC6	ATP binding cassette subfamily C member 6	0.4277	67
TXNRD2	Thioredoxin reductase 2	0.4237	47
EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	0.4203	67
SP2	Sp2 transcription factor	0.4163	59
TP53INP1	Tumor protein p53 inducible nuclear protein 1	0.4160	55
GLUD1	Glutamate dehydrogenase 1	0.4043	41
ALDH4A1	Aldehyde dehydrogenase 4 family member A1	0.4040	67
NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit	0.3995	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.6 nTPM
Adipose tissue	7.5 nTPM
Breast	3.6 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	18.5 nTPM
Lung	18.5 nTPM

Astrocytes	21.5 nTPM
Brain	21.5 nTPM

B-cells	14.9 nTPM
Bone marrow	22.9 nTPM
Stomach	20.0 nTPM
Liver	19.7 nTPM
Spleen	16.9 nTPM
Colon	16.0 nTPM
Lymph node	15.6 nTPM
Kidney	14.3 nTPM
Adipose tissue	11.5 nTPM
Breast	6.6 nTPM
PBMC	5.7 nTPM

Dendritic cells	6.7 nTPM
Adipose tissue	8.5 nTPM
PBMC	8.0 nTPM
Breast	3.6 nTPM

Endothelial cells	7.1 nTPM
Lung	15.6 nTPM
Pancreas	11.6 nTPM
Skin	10.6 nTPM
Ovary	7.9 nTPM
Skeletal muscle	7.8 nTPM
Prostate	7.4 nTPM
Testis	7.4 nTPM
Esophagus	7.3 nTPM
Endometrium	7.0 nTPM
Breast	5.8 nTPM
Placenta	5.7 nTPM
Liver	3.7 nTPM
Eye	1.6 nTPM
Heart muscle	0.0 nTPM

Fibroblasts	6.1 nTPM
Placenta	12.5 nTPM
Skin	10.0 nTPM
Skeletal muscle	7.7 nTPM
Ovary	7.2 nTPM
Adipose tissue	6.8 nTPM
Stomach	6.0 nTPM
Lung	5.6 nTPM
Breast	4.4 nTPM
Esophagus	3.8 nTPM
Prostate	2.9 nTPM
Heart muscle	0.0 nTPM

Intestinal goblet cells	13.7 nTPM
Small intestine	15.3 nTPM
Rectum	14.3 nTPM
Colon	11.4 nTPM

Macrophages	8.6 nTPM
Spleen	19.7 nTPM
Esophagus	17.3 nTPM
Stomach	14.7 nTPM
Bone marrow	13.8 nTPM
Adipose tissue	11.1 nTPM
Skeletal muscle	10.0 nTPM
Prostate	9.1 nTPM
Kidney	8.3 nTPM
Ovary	7.0 nTPM
Testis	5.2 nTPM
Lung	5.0 nTPM
Endometrium	3.8 nTPM
Breast	3.6 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	8.2 nTPM
Rectum	11.1 nTPM
Colon	9.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	27.4 nTPM
Stomach	43.3 nTPM
Spleen	33.6 nTPM
Esophagus	30.7 nTPM
Bone marrow	19.8 nTPM
Adipose tissue	9.7 nTPM

Respiratory ciliated cells	10.4 nTPM
Bronchus	17.8 nTPM
Lung	2.9 nTPM

Smooth muscle cells	7.2 nTPM
Bronchus	27.5 nTPM
Prostate	10.6 nTPM
Pancreas	9.4 nTPM
Skeletal muscle	7.2 nTPM
Ovary	6.5 nTPM
Skin	4.9 nTPM
Adipose tissue	4.3 nTPM
Endometrium	4.1 nTPM
Esophagus	3.1 nTPM
Breast	2.0 nTPM
Heart muscle	0.0 nTPM

T-cells	10.3 nTPM
Stomach	19.4 nTPM
Colon	17.1 nTPM
Skin	17.1 nTPM
Spleen	16.4 nTPM
Bone marrow	15.9 nTPM
Kidney	15.8 nTPM
Lymph node	14.8 nTPM
Adipose tissue	10.2 nTPM
Skeletal muscle	8.2 nTPM
Ovary	6.7 nTPM
Endometrium	6.3 nTPM
PBMC	5.8 nTPM
Breast	5.8 nTPM
Liver	5.7 nTPM
Prostate	4.7 nTPM
Lung	4.5 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	15.0 nTPM
Skin	15.0 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Cytotrophoblasts	21.6 nTPM
Placenta	21.6 nTPM

Distal enterocytes	20.2 nTPM
Rectum	21.6 nTPM
Colon	18.8 nTPM

Undifferentiated cells	13.9 nTPM
Rectum	14.4 nTPM
Colon	14.2 nTPM
Small intestine	13.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC