Single cell type - FAM107B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM107B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 107 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	20

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, HDLM-2, Karpas-707, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM107B is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CDC42SE2	CDC42 small effector 2	0.7301	24
ETS1	ETS proto-oncogene 1, transcription factor	0.7077	24
CASP8	Caspase 8	0.6555	24
RNF19A	Ring finger protein 19A, RBR E3 ubiquitin protein ligase	0.6548	24
BICDL1	BICD family like cargo adaptor 1	0.6533	24
CCR8	C-C motif chemokine receptor 8	0.6472	24
ZNF831	Zinc finger protein 831	0.6351	24
H2AC15	H2A clustered histone 15	0.6333	24
CNOT6L	CCR4-NOT transcription complex subunit 6 like	0.6278	24
PMCH	Pro-melanin concentrating hormone	0.6224	24
CCR4	C-C motif chemokine receptor 4	0.6213	24
BATF	Basic leucine zipper ATF-like transcription factor	0.6095	24
ELF1	E74 like ETS transcription factor 1	0.6068	24
PBX4	PBX homeobox 4	0.6063	24
IL7R	Interleukin 7 receptor	0.6042	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.8 nTPM
Breast	12.8 nTPM
Adipose tissue	12.7 nTPM

Alveolar cells type 1	105.8 nTPM
Lung	105.8 nTPM

Alveolar cells type 2	44.4 nTPM
Lung	44.4 nTPM

Astrocytes	7.2 nTPM
Brain	7.2 nTPM

B-cells	203.6 nTPM
Adipose tissue	537.4 nTPM
Colon	311.5 nTPM
Stomach	295.2 nTPM
Lymph node	182.1 nTPM
Breast	152.6 nTPM
Bone marrow	141.4 nTPM
PBMC	124.2 nTPM
Spleen	114.5 nTPM
Kidney	114.3 nTPM
Liver	62.4 nTPM

Dendritic cells	194.7 nTPM
Adipose tissue	362.1 nTPM
Breast	154.2 nTPM
PBMC	67.8 nTPM

Endothelial cells	37.8 nTPM
Endometrium	77.9 nTPM
Skin	70.0 nTPM
Liver	69.7 nTPM
Prostate	61.0 nTPM
Ovary	52.2 nTPM
Eye	41.2 nTPM
Lung	37.4 nTPM
Breast	32.7 nTPM
Pancreas	23.1 nTPM
Placenta	21.0 nTPM
Esophagus	13.5 nTPM
Skeletal muscle	13.1 nTPM
Heart muscle	10.6 nTPM
Testis	5.9 nTPM

Fibroblasts	49.7 nTPM
Prostate	143.3 nTPM
Lung	93.8 nTPM
Skin	68.9 nTPM
Skeletal muscle	64.4 nTPM
Stomach	56.4 nTPM
Adipose tissue	49.3 nTPM
Breast	30.4 nTPM
Esophagus	12.5 nTPM
Heart muscle	11.4 nTPM
Placenta	8.9 nTPM
Ovary	6.9 nTPM

Intestinal goblet cells	110.5 nTPM
Colon	155.1 nTPM
Small intestine	118.3 nTPM
Rectum	58.1 nTPM

Macrophages	110.7 nTPM
Adipose tissue	277.1 nTPM
Prostate	237.3 nTPM
Endometrium	184.9 nTPM
Stomach	134.8 nTPM
Skeletal muscle	133.2 nTPM
Spleen	120.3 nTPM
Kidney	112.7 nTPM
Bone marrow	98.7 nTPM
Breast	81.8 nTPM
Lung	63.9 nTPM
Ovary	58.8 nTPM
Pancreas	46.0 nTPM
Esophagus	45.6 nTPM
PBMC	40.9 nTPM
Testis	25.0 nTPM

Paneth cells	44.3 nTPM
Colon	98.9 nTPM
Rectum	19.0 nTPM
Small intestine	15.0 nTPM

Plasma cells	176.6 nTPM
Adipose tissue	443.1 nTPM
Stomach	256.5 nTPM
Spleen	96.3 nTPM
Bone marrow	62.6 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	85.3 nTPM
Lung	99.1 nTPM
Bronchus	71.4 nTPM

Smooth muscle cells	64.6 nTPM
Prostate	136.3 nTPM
Adipose tissue	113.7 nTPM
Endometrium	90.7 nTPM
Skin	90.0 nTPM
Breast	74.9 nTPM
Skeletal muscle	56.1 nTPM
Esophagus	41.9 nTPM
Ovary	36.4 nTPM
Heart muscle	33.4 nTPM
Bronchus	27.2 nTPM
Pancreas	10.2 nTPM

T-cells	237.7 nTPM
Adipose tissue	883.1 nTPM
Prostate	421.3 nTPM
Skeletal muscle	312.5 nTPM
PBMC	220.0 nTPM
Endometrium	216.2 nTPM
Lymph node	211.1 nTPM
Skin	204.9 nTPM
Breast	203.5 nTPM
Stomach	192.0 nTPM
Colon	183.0 nTPM
Kidney	181.4 nTPM
Spleen	180.5 nTPM
Bone marrow	165.0 nTPM
Liver	144.8 nTPM
Ovary	122.4 nTPM
Lung	107.8 nTPM
Esophagus	91.7 nTPM

Basal keratinocytes	89.7 nTPM
Skin	89.7 nTPM

Basal prostatic cells	147.1 nTPM
Prostate	147.1 nTPM

Basal respiratory cells	25.4 nTPM
Bronchus	25.4 nTPM

Basal squamous epithelial cells	16.5 nTPM
Esophagus	16.5 nTPM

Undifferentiated cells	39.9 nTPM
Colon	57.8 nTPM
Small intestine	44.7 nTPM
Rectum	17.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC