Single cell type - DIP2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DIP2B
Gene descriptionⁱ Full gene name according to HGNC.	Disco interacting protein 2 homolog B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Microglial cells, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Microglial cells, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DIP2B is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HS3ST5	Heparan sulfate-glucosamine 3-sulfotransferase 5	0.8038	42
MAGEC3	MAGE family member C3	0.7991	42
PEX5L	Peroxisomal biogenesis factor 5 like	0.7922	42
TMEFF2	Transmembrane protein with EGF like and two follistatin like domains 2	0.7920	42
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.7899	42
MAN2A1	Mannosidase alpha class 2A member 1	0.7584	42
SLC24A2	Solute carrier family 24 member 2	0.7572	42
PKP4	Plakophilin 4	0.7476	42
JAKMIP3	Janus kinase and microtubule interacting protein 3	0.7353	42
SLC22A15	Solute carrier family 22 member 15	0.7315	42
TMTC2	Transmembrane O-mannosyltransferase targeting cadherins 2	0.7300	42
ANKIB1	Ankyrin repeat and IBR domain containing 1	0.7294	42
CHRM5	Cholinergic receptor muscarinic 5	0.7272	42
AKAP6	A-kinase anchoring protein 6	0.7250	42
PDE8A	Phosphodiesterase 8A	0.7243	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	15.4 nTPM
Adipose tissue	18.7 nTPM
Breast	12.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	10.5 nTPM
Lung	10.5 nTPM

Astrocytes	74.1 nTPM
Brain	74.1 nTPM

B-cells	26.3 nTPM
Bone marrow	46.6 nTPM
Lymph node	41.3 nTPM
Stomach	35.4 nTPM
Spleen	34.6 nTPM
Adipose tissue	32.6 nTPM
Kidney	23.8 nTPM
Colon	16.0 nTPM
Liver	13.2 nTPM
PBMC	9.9 nTPM
Breast	9.4 nTPM

Dendritic cells	9.2 nTPM
Adipose tissue	15.5 nTPM
Breast	8.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	15.5 nTPM
Esophagus	23.8 nTPM
Testis	21.7 nTPM
Prostate	20.3 nTPM
Ovary	18.7 nTPM
Heart muscle	17.3 nTPM
Skin	15.8 nTPM
Liver	15.6 nTPM
Eye	15.4 nTPM
Skeletal muscle	14.5 nTPM
Endometrium	14.0 nTPM
Breast	13.9 nTPM
Pancreas	11.6 nTPM
Placenta	10.8 nTPM
Lung	3.1 nTPM

Fibroblasts	11.2 nTPM
Ovary	18.2 nTPM
Prostate	15.2 nTPM
Stomach	13.4 nTPM
Adipose tissue	11.6 nTPM
Esophagus	10.7 nTPM
Heart muscle	10.4 nTPM
Skin	9.7 nTPM
Skeletal muscle	9.6 nTPM
Placenta	9.0 nTPM
Lung	7.8 nTPM
Breast	7.7 nTPM

Intestinal goblet cells	18.3 nTPM
Rectum	23.5 nTPM
Small intestine	20.8 nTPM
Colon	10.7 nTPM

Macrophages	24.5 nTPM
Spleen	48.8 nTPM
Esophagus	45.6 nTPM
Bone marrow	36.3 nTPM
Ovary	35.7 nTPM
Skeletal muscle	34.6 nTPM
Pancreas	28.0 nTPM
Adipose tissue	25.6 nTPM
Testis	22.1 nTPM
Stomach	17.6 nTPM
Endometrium	14.0 nTPM
PBMC	13.6 nTPM
Breast	13.6 nTPM
Prostate	12.6 nTPM
Lung	11.7 nTPM
Kidney	8.3 nTPM

Paneth cells	14.0 nTPM
Rectum	18.0 nTPM
Colon	16.5 nTPM
Small intestine	7.5 nTPM

Plasma cells	15.4 nTPM
Bone marrow	21.4 nTPM
Adipose tissue	20.6 nTPM
Stomach	14.7 nTPM
Spleen	13.9 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	8.8 nTPM
Bronchus	13.2 nTPM
Lung	4.4 nTPM

Smooth muscle cells	10.0 nTPM
Bronchus	23.6 nTPM
Ovary	13.8 nTPM
Prostate	11.6 nTPM
Skin	10.1 nTPM
Endometrium	9.7 nTPM
Adipose tissue	8.3 nTPM
Esophagus	7.8 nTPM
Pancreas	7.6 nTPM
Heart muscle	7.5 nTPM
Skeletal muscle	5.8 nTPM
Breast	4.5 nTPM

T-cells	13.3 nTPM
Lymph node	26.7 nTPM
Esophagus	26.2 nTPM
Prostate	23.6 nTPM
Bone marrow	17.3 nTPM
Adipose tissue	16.2 nTPM
PBMC	15.2 nTPM
Skeletal muscle	14.2 nTPM
Stomach	13.2 nTPM
Spleen	13.0 nTPM
Endometrium	9.4 nTPM
Skin	8.3 nTPM
Kidney	8.2 nTPM
Colon	8.1 nTPM
Liver	7.9 nTPM
Breast	7.8 nTPM
Lung	6.1 nTPM
Ovary	4.5 nTPM

Basal keratinocytes	54.9 nTPM
Skin	54.9 nTPM

Basal prostatic cells	30.2 nTPM
Prostate	30.2 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	12.4 nTPM
Rectum	16.8 nTPM
Colon	10.9 nTPM
Small intestine	9.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC