Single cell type - INPP5A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	INPP5A
Gene descriptionⁱ Full gene name according to HGNC.	Inositol polyphosphate-5-phosphatase A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

INPP5A is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ROCK2	Rho associated coiled-coil containing protein kinase 2	0.6217	48
ARHGEF17	Rho guanine nucleotide exchange factor 17	0.6108	48
PDGFA	Platelet derived growth factor subunit A	0.5726	48
CCDC3	Coiled-coil domain containing 3	0.5222	48
SCN4B	Sodium voltage-gated channel beta subunit 4	0.5148	48
LGI4	Leucine rich repeat LGI family member 4	0.5093	48
AVPR1A	Arginine vasopressin receptor 1A	0.4996	48
ADCY6	Adenylate cyclase 6	0.4993	53
MYLK	Myosin light chain kinase	0.4955	48
MOB3B	MOB kinase activator 3B	0.4894	42
RCAN2	Regulator of calcineurin 2	0.4853	48
SYNPO2	Synaptopodin 2	0.4815	48
ARHGEF7	Rho guanine nucleotide exchange factor 7	0.4801	21
ADCY9	Adenylate cyclase 9	0.4793	21
ARHGEF25	Rho guanine nucleotide exchange factor 25	0.4728	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.7 nTPM
Adipose tissue	16.4 nTPM
Breast	13.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	19.7 nTPM
Lung	19.7 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	4.5 nTPM
Adipose tissue	25.1 nTPM
Breast	5.3 nTPM
Colon	4.8 nTPM
PBMC	2.8 nTPM
Stomach	2.2 nTPM
Liver	1.8 nTPM
Spleen	1.4 nTPM
Lymph node	1.2 nTPM
Bone marrow	0.8 nTPM
Kidney	0.0 nTPM

Dendritic cells	5.0 nTPM
Adipose tissue	11.7 nTPM
Breast	3.3 nTPM
PBMC	0.0 nTPM

Endothelial cells	10.0 nTPM
Endometrium	18.9 nTPM
Lung	15.6 nTPM
Skeletal muscle	15.0 nTPM
Eye	14.6 nTPM
Ovary	13.6 nTPM
Breast	10.7 nTPM
Pancreas	7.7 nTPM
Skin	7.7 nTPM
Prostate	7.4 nTPM
Placenta	7.3 nTPM
Liver	6.4 nTPM
Esophagus	6.2 nTPM
Testis	4.7 nTPM
Heart muscle	4.1 nTPM

Fibroblasts	5.6 nTPM
Adipose tissue	12.1 nTPM
Skeletal muscle	8.6 nTPM
Placenta	8.3 nTPM
Ovary	7.7 nTPM
Skin	7.2 nTPM
Breast	4.9 nTPM
Esophagus	4.3 nTPM
Heart muscle	3.9 nTPM
Prostate	2.4 nTPM
Stomach	1.5 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	9.9 nTPM
Rectum	13.6 nTPM
Colon	10.0 nTPM
Small intestine	6.1 nTPM

Macrophages	6.9 nTPM
PBMC	40.9 nTPM
Spleen	11.4 nTPM
Skeletal muscle	11.2 nTPM
Adipose tissue	10.5 nTPM
Lung	5.4 nTPM
Ovary	4.0 nTPM
Endometrium	3.8 nTPM
Bone marrow	3.7 nTPM
Prostate	3.4 nTPM
Esophagus	3.1 nTPM
Kidney	3.0 nTPM
Breast	2.5 nTPM
Testis	0.6 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	11.5 nTPM
Rectum	13.7 nTPM
Colon	13.2 nTPM
Small intestine	7.5 nTPM

Plasma cells	2.5 nTPM
Adipose tissue	10.9 nTPM
Stomach	1.0 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	2.5 nTPM
Lung	2.9 nTPM
Bronchus	2.1 nTPM

Smooth muscle cells	24.3 nTPM
Adipose tissue	44.0 nTPM
Skin	39.4 nTPM
Skeletal muscle	36.1 nTPM
Breast	32.2 nTPM
Endometrium	30.7 nTPM
Prostate	24.4 nTPM
Heart muscle	22.1 nTPM
Esophagus	20.1 nTPM
Ovary	10.7 nTPM
Pancreas	6.9 nTPM
Bronchus	0.9 nTPM

T-cells	2.7 nTPM
Adipose tissue	8.1 nTPM
Endometrium	6.7 nTPM
Skin	6.4 nTPM
Skeletal muscle	4.2 nTPM
Lung	3.0 nTPM
Colon	2.9 nTPM
Breast	2.9 nTPM
Ovary	2.2 nTPM
Kidney	2.0 nTPM
Lymph node	2.0 nTPM
Liver	1.9 nTPM
PBMC	1.6 nTPM
Spleen	1.0 nTPM
Stomach	0.7 nTPM
Bone marrow	0.6 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Basal prostatic cells	4.4 nTPM
Prostate	4.4 nTPM

Distal enterocytes	24.8 nTPM
Rectum	28.7 nTPM
Colon	20.9 nTPM

Early spermatids	12.3 nTPM
Testis	12.3 nTPM

Endometrial stromal cells	22.8 nTPM
Endometrium	22.8 nTPM

Undifferentiated cells	13.9 nTPM
Colon	15.5 nTPM
Rectum	15.1 nTPM
Small intestine	11.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC