Single cell type - DERL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DERL2
Gene descriptionⁱ Full gene name according to HGNC.	Derlin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DERL2 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SPCS2	Signal peptidase complex subunit 2	0.6368	55
LMAN2	Lectin, mannose binding 2	0.5937	55
ERGIC2	ERGIC and golgi 2	0.5931	29
TMEM45A	Transmembrane protein 45A	0.5919	26
PLRG1	Pleiotropic regulator 1	0.5880	26
FDFT1	Farnesyl-diphosphate farnesyltransferase 1	0.5684	26
TMED10	Transmembrane p24 trafficking protein 10	0.5641	55
PTHLH	Parathyroid hormone like hormone	0.5627	26
LMAN1	Lectin, mannose binding 1	0.5622	55
ALG5	ALG5 dolichyl-phosphate beta-glucosyltransferase	0.5609	55
ERLEC1	Endoplasmic reticulum lectin 1	0.5608	55
OSTC	Oligosaccharyltransferase complex non-catalytic subunit	0.5466	55
DAD1	Defender against cell death 1	0.5204	55
MFSD10	Major facilitator superfamily domain containing 10	0.5152	26
FAM83A	Family with sequence similarity 83 member A	0.5114	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.1 nTPM
Breast	41.5 nTPM
Adipose tissue	30.7 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	23.9 nTPM
Lung	23.9 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	46.4 nTPM
Liver	112.9 nTPM
Breast	77.5 nTPM
Stomach	49.9 nTPM
Colon	49.5 nTPM
Spleen	37.7 nTPM
PBMC	35.7 nTPM
Lymph node	34.5 nTPM
Adipose tissue	32.6 nTPM
Bone marrow	24.5 nTPM
Kidney	9.5 nTPM

Dendritic cells	70.5 nTPM
Adipose tissue	77.9 nTPM
Breast	69.9 nTPM
PBMC	63.8 nTPM

Endothelial cells	35.7 nTPM
Pancreas	61.8 nTPM
Placenta	48.9 nTPM
Heart muscle	48.8 nTPM
Ovary	41.6 nTPM
Prostate	40.3 nTPM
Skin	37.2 nTPM
Breast	35.7 nTPM
Esophagus	29.7 nTPM
Endometrium	28.9 nTPM
Lung	28.1 nTPM
Liver	27.5 nTPM
Testis	24.6 nTPM
Eye	23.5 nTPM
Skeletal muscle	23.5 nTPM

Fibroblasts	51.3 nTPM
Placenta	80.8 nTPM
Heart muscle	70.5 nTPM
Prostate	67.5 nTPM
Breast	59.9 nTPM
Adipose tissue	55.9 nTPM
Ovary	46.0 nTPM
Stomach	46.0 nTPM
Skin	43.9 nTPM
Skeletal muscle	37.2 nTPM
Esophagus	31.5 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	37.2 nTPM
Colon	60.1 nTPM
Small intestine	29.7 nTPM
Rectum	21.7 nTPM

Macrophages	37.8 nTPM
Pancreas	97.0 nTPM
Kidney	56.7 nTPM
Breast	48.5 nTPM
Prostate	45.8 nTPM
Ovary	44.7 nTPM
Stomach	38.1 nTPM
Endometrium	36.9 nTPM
Adipose tissue	31.8 nTPM
Bone marrow	30.0 nTPM
Testis	28.4 nTPM
Lung	28.3 nTPM
Skeletal muscle	24.0 nTPM
Spleen	23.9 nTPM
Esophagus	18.9 nTPM
PBMC	13.6 nTPM

Paneth cells	25.2 nTPM
Rectum	35.7 nTPM
Small intestine	30.0 nTPM
Colon	9.9 nTPM

Plasma cells	119.9 nTPM
Stomach	183.1 nTPM
Spleen	164.6 nTPM
Esophagus	92.4 nTPM
Bone marrow	92.3 nTPM
Adipose tissue	67.1 nTPM

Respiratory ciliated cells	55.6 nTPM
Bronchus	71.9 nTPM
Lung	39.4 nTPM

Smooth muscle cells	54.3 nTPM
Pancreas	118.1 nTPM
Heart muscle	101.2 nTPM
Bronchus	88.7 nTPM
Ovary	59.7 nTPM
Breast	39.5 nTPM
Skeletal muscle	35.8 nTPM
Prostate	33.4 nTPM
Esophagus	32.5 nTPM
Endometrium	30.9 nTPM
Adipose tissue	30.7 nTPM
Skin	27.3 nTPM

T-cells	47.7 nTPM
Ovary	86.7 nTPM
Colon	65.1 nTPM
Adipose tissue	63.6 nTPM
Breast	58.3 nTPM
Skin	55.8 nTPM
Kidney	55.4 nTPM
Stomach	55.3 nTPM
Prostate	52.1 nTPM
Lung	44.0 nTPM
Liver	41.1 nTPM
Spleen	41.1 nTPM
Endometrium	40.8 nTPM
Bone marrow	40.0 nTPM
PBMC	36.7 nTPM
Skeletal muscle	34.3 nTPM
Lymph node	34.1 nTPM
Esophagus	6.6 nTPM

Basal prostatic cells	50.5 nTPM
Prostate	50.5 nTPM

Basal respiratory cells	157.7 nTPM
Bronchus	157.7 nTPM

Collecting duct cells	44.1 nTPM
Kidney	44.1 nTPM

Cone photoreceptor cells	22.9 nTPM
Eye	22.9 nTPM

Undifferentiated cells	30.4 nTPM
Small intestine	35.7 nTPM
Colon	30.9 nTPM
Rectum	24.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC