Cell line - KLHL20 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KLHL20
Gene descriptionⁱ Full gene name according to HGNC.	Kelch like family member 20
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mesenchymal cell lines - ECM organization (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

KLHL20 is part of cluster 34 Mesenchymal cell lines - ECM organization with confidenceⁱ 0.77
626 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NEGR1	Neuronal growth regulator 1	0.6206	41
PRDX6	Peroxiredoxin 6	0.6073	34
DEGS1	Delta 4-desaturase, sphingolipid 1	0.6063	34
CA5B	Carbonic anhydrase 5B	0.5870	30
EXT2	Exostosin glycosyltransferase 2	0.5743	10
GADD45B	Growth arrest and DNA damage inducible beta	0.5700	10
ACBD3	Acyl-CoA binding domain containing 3	0.5626	18
UAP1	UDP-N-acetylglucosamine pyrophosphorylase 1	0.5431	30
TMEM43	Transmembrane protein 43	0.5348	34
STYX	Serine/threonine/tyrosine interacting protein	0.5231	6
FEZ2	Fasciculation and elongation protein zeta 2	0.5229	10
COPA	COPI coat complex subunit alpha	0.5223	10
FBXO28	F-box protein 28	0.5209	17
POLR2M	RNA polymerase II subunit M	0.5206	30
ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif 4	0.5200	41