Cell line - GADD45B - The Human Protein Atlas

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GADD45B

SUMMARY

TISSUE

BRAIN

SINGLE CELL

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GADD45B
Gene descriptionⁱ Full gene name according to HGNC.	Growth arrest and DNA damage inducible beta
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	BJ & FHDF - ECM organization (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

GADD45B is part of cluster 10 BJ & FHDF - ECM organization with confidenceⁱ 0.98
568 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NR3C1	Nuclear receptor subfamily 3 group C member 1	0.5976	10
BNC2	Basonuclin 2	0.5848	2
DNASE1L1	Deoxyribonuclease 1 like 1	0.5759	41
MAP7D3	MAP7 domain containing 3	0.5757	10
CCN1	Cellular communication network factor 1	0.5753	10
KLHL20	Kelch like family member 20	0.5700	34
GOLIM4	Golgi integral membrane protein 4	0.5595	10
ATL3	Atlastin GTPase 3	0.5559	20
CCN2	Cellular communication network factor 2	0.5514	41
PDGFB	Platelet derived growth factor subunit B	0.5490	38
EGFLAM	EGF like, fibronectin type III and laminin G domains	0.5488	10
CCDC50	Coiled-coil domain containing 50	0.5393	10
PTPN14	Protein tyrosine phosphatase non-receptor type 14	0.5374	10
TUBB6	Tubulin beta 6 class V	0.5314	10
NABP1	Nucleic acid binding protein 1	0.5308	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.