Single cell type - DUSP12 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DUSP12
Gene descriptionⁱ Full gene name according to HGNC.	Dual specificity phosphatase 12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DUSP12 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBE2I	Ubiquitin conjugating enzyme E2 I	0.5590	10
PPIH	Peptidylprolyl isomerase H	0.5164	10
MED8	Mediator complex subunit 8	0.5064	10
EXOSC1	Exosome component 1	0.5052	63
NME1	NME/NM23 nucleoside diphosphate kinase 1	0.4984	10
TRIB2	Tribbles pseudokinase 2	0.4865	40
TINF2	TERF1 interacting nuclear factor 2	0.4860	63
B3GAT3	Beta-1,3-glucuronyltransferase 3	0.4726	4
PDCD2	Programmed cell death 2	0.4680	32
TMEM203	Transmembrane protein 203	0.4665	10
APOBEC3C	Apolipoprotein B mRNA editing enzyme catalytic subunit 3C	0.4597	63
PRAF2	PRA1 domain family member 2	0.4596	33
PRMT1	Protein arginine methyltransferase 1	0.4566	10
SRP72	Signal recognition particle 72	0.4562	55
RPS7	Ribosomal protein S7	0.4550	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.9 nTPM
Breast	28.7 nTPM
Adipose tissue	17.2 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	12.8 nTPM
Lung	12.8 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	25.5 nTPM
PBMC	35.7 nTPM
Liver	35.3 nTPM
Stomach	31.8 nTPM
Colon	27.1 nTPM
Spleen	26.0 nTPM
Kidney	23.8 nTPM
Bone marrow	22.9 nTPM
Adipose tissue	21.6 nTPM
Lymph node	16.1 nTPM
Breast	14.7 nTPM

Dendritic cells	26.4 nTPM
Adipose tissue	42.9 nTPM
Breast	28.4 nTPM
PBMC	8.0 nTPM

Endothelial cells	18.4 nTPM
Pancreas	34.7 nTPM
Placenta	25.0 nTPM
Testis	24.3 nTPM
Prostate	22.8 nTPM
Skin	22.1 nTPM
Ovary	21.7 nTPM
Breast	17.8 nTPM
Skeletal muscle	17.7 nTPM
Endometrium	16.4 nTPM
Heart muscle	16.1 nTPM
Lung	12.5 nTPM
Liver	11.0 nTPM
Esophagus	10.8 nTPM
Eye	4.8 nTPM

Fibroblasts	17.3 nTPM
Placenta	27.3 nTPM
Breast	25.1 nTPM
Adipose tissue	20.4 nTPM
Skin	19.5 nTPM
Ovary	18.7 nTPM
Prostate	18.2 nTPM
Stomach	16.3 nTPM
Skeletal muscle	15.6 nTPM
Esophagus	13.1 nTPM
Heart muscle	9.0 nTPM
Lung	6.7 nTPM

Intestinal goblet cells	9.8 nTPM
Rectum	11.2 nTPM
Colon	9.3 nTPM
Small intestine	8.9 nTPM

Macrophages	15.4 nTPM
Testis	29.1 nTPM
Stomach	26.4 nTPM
Breast	21.5 nTPM
Pancreas	20.4 nTPM
Adipose tissue	16.2 nTPM
Prostate	16.0 nTPM
Ovary	15.1 nTPM
Spleen	14.5 nTPM
Kidney	14.3 nTPM
Endometrium	14.3 nTPM
Esophagus	14.2 nTPM
Skeletal muscle	12.2 nTPM
Lung	9.7 nTPM
Bone marrow	7.5 nTPM
PBMC	0.0 nTPM

Paneth cells	6.5 nTPM
Rectum	13.1 nTPM
Colon	6.5 nTPM
Small intestine	0.0 nTPM

Plasma cells	27.5 nTPM
Spleen	41.9 nTPM
Bone marrow	41.2 nTPM
Stomach	39.5 nTPM
Adipose tissue	14.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	7.0 nTPM
Bronchus	9.7 nTPM
Lung	4.4 nTPM

Smooth muscle cells	24.5 nTPM
Bronchus	51.1 nTPM
Pancreas	37.0 nTPM
Ovary	33.4 nTPM
Breast	24.7 nTPM
Prostate	22.6 nTPM
Skin	20.9 nTPM
Endometrium	17.8 nTPM
Adipose tissue	17.6 nTPM
Skeletal muscle	16.2 nTPM
Heart muscle	15.7 nTPM
Esophagus	12.4 nTPM

T-cells	23.5 nTPM
Ovary	37.8 nTPM
Stomach	32.6 nTPM
PBMC	27.4 nTPM
Adipose tissue	25.8 nTPM
Bone marrow	25.8 nTPM
Spleen	23.9 nTPM
Liver	23.7 nTPM
Prostate	23.6 nTPM
Colon	23.3 nTPM
Breast	23.3 nTPM
Lung	21.3 nTPM
Kidney	21.2 nTPM
Skin	19.8 nTPM
Esophagus	19.7 nTPM
Lymph node	18.9 nTPM
Endometrium	16.3 nTPM
Skeletal muscle	14.7 nTPM

Basal keratinocytes	13.6 nTPM
Skin	13.6 nTPM

Basal prostatic cells	14.4 nTPM
Prostate	14.4 nTPM

Basal respiratory cells	25.9 nTPM
Bronchus	25.9 nTPM

Basal squamous epithelial cells	25.6 nTPM
Esophagus	25.6 nTPM

Undifferentiated cells	12.1 nTPM
Small intestine	13.8 nTPM
Rectum	12.0 nTPM
Colon	10.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC