Single cell type - EIF3I - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF3I
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 3 subunit I
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	23

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EIF3I is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.7844	10
EIF3H	Eukaryotic translation initiation factor 3 subunit H	0.7738	10
PSMB2	Proteasome 20S subunit beta 2	0.7595	10
ESD	Esterase D	0.7502	10
PARL	Presenilin associated rhomboid like	0.7468	10
EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.7380	10
NUTF2	Nuclear transport factor 2	0.7340	10
PSMB3	Proteasome 20S subunit beta 3	0.7275	10
RRP9	Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein	0.7255	10
FCF1	FCF1 rRNA-processing protein	0.7137	10
ZNF90	Zinc finger protein 90	0.7057	10
PSMA7	Proteasome 20S subunit alpha 7	0.7034	10
PHB	Prohibitin	0.6985	10
GSTA5	Glutathione S-transferase alpha 5	0.6934	10
HNRNPCL1	Heterogeneous nuclear ribonucleoprotein C like 1	0.6926	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	136.9 nTPM
Adipose tissue	147.5 nTPM
Breast	126.4 nTPM

Alveolar cells type 1	51.3 nTPM
Lung	51.3 nTPM

Alveolar cells type 2	76.7 nTPM
Lung	76.7 nTPM

Astrocytes	6.8 nTPM
Brain	6.8 nTPM

B-cells	114.5 nTPM
Liver	215.9 nTPM
Colon	151.8 nTPM
PBMC	149.9 nTPM
Kidney	123.8 nTPM
Spleen	99.0 nTPM
Adipose tissue	95.8 nTPM
Breast	88.2 nTPM
Stomach	88.1 nTPM
Lymph node	70.1 nTPM
Bone marrow	62.1 nTPM

Dendritic cells	118.2 nTPM
PBMC	131.5 nTPM
Adipose tissue	114.0 nTPM
Breast	109.0 nTPM

Endothelial cells	163.5 nTPM
Prostate	400.1 nTPM
Pancreas	316.6 nTPM
Placenta	252.9 nTPM
Testis	179.3 nTPM
Skin	175.3 nTPM
Ovary	144.2 nTPM
Skeletal muscle	126.8 nTPM
Lung	124.7 nTPM
Breast	121.2 nTPM
Liver	119.3 nTPM
Eye	104.4 nTPM
Endometrium	101.4 nTPM
Esophagus	93.8 nTPM
Heart muscle	28.8 nTPM

Enteroendocrine cells	138.6 nTPM
Colon	177.7 nTPM
Rectum	99.5 nTPM

Fibroblasts	125.6 nTPM
Prostate	224.9 nTPM
Placenta	176.8 nTPM
Ovary	163.8 nTPM
Lung	139.6 nTPM
Adipose tissue	132.3 nTPM
Skin	124.1 nTPM
Stomach	118.8 nTPM
Breast	105.6 nTPM
Skeletal muscle	87.5 nTPM
Esophagus	76.0 nTPM
Heart muscle	31.9 nTPM

Intestinal goblet cells	184.0 nTPM
Colon	326.6 nTPM
Rectum	124.6 nTPM
Small intestine	100.7 nTPM

Macrophages	108.8 nTPM
Pancreas	229.7 nTPM
Kidney	170.1 nTPM
Prostate	143.4 nTPM
Adipose tissue	141.4 nTPM
Ovary	120.9 nTPM
Testis	115.0 nTPM
Endometrium	106.2 nTPM
Breast	102.5 nTPM
Lung	100.5 nTPM
Skeletal muscle	87.5 nTPM
Bone marrow	71.2 nTPM
Esophagus	67.7 nTPM
Spleen	67.4 nTPM
Stomach	67.4 nTPM
PBMC	40.9 nTPM

Paneth cells	115.6 nTPM
Rectum	164.8 nTPM
Small intestine	112.7 nTPM
Colon	69.2 nTPM

Plasma cells	107.5 nTPM
Spleen	145.9 nTPM
Bone marrow	133.5 nTPM
Stomach	106.9 nTPM
Esophagus	86.2 nTPM
Adipose tissue	65.2 nTPM

Respiratory ciliated cells	99.2 nTPM
Bronchus	99.2 nTPM
Lung	99.1 nTPM

Smooth muscle cells	338.3 nTPM
Bronchus	2106.8 nTPM
Pancreas	427.7 nTPM
Skin	239.7 nTPM
Prostate	235.4 nTPM
Ovary	181.4 nTPM
Breast	119.8 nTPM
Skeletal muscle	112.4 nTPM
Adipose tissue	98.3 nTPM
Endometrium	87.0 nTPM
Esophagus	79.1 nTPM
Heart muscle	34.1 nTPM

Basal keratinocytes	136.6 nTPM
Skin	136.6 nTPM

Basal prostatic cells	227.6 nTPM
Prostate	227.6 nTPM

Basal respiratory cells	275.6 nTPM
Bronchus	275.6 nTPM

Basal squamous epithelial cells	84.8 nTPM
Esophagus	84.8 nTPM

T-cells	115.1 nTPM
Colon	171.5 nTPM
Ovary	164.6 nTPM
PBMC	158.3 nTPM
Kidney	153.4 nTPM
Skin	151.6 nTPM
Liver	143.2 nTPM
Adipose tissue	126.6 nTPM
Lung	116.9 nTPM
Breast	100.8 nTPM
Stomach	98.2 nTPM
Prostate	85.2 nTPM
Esophagus	85.2 nTPM
Spleen	84.2 nTPM
Endometrium	83.8 nTPM
Skeletal muscle	78.9 nTPM
Lymph node	78.0 nTPM
Bone marrow	75.9 nTPM

Undifferentiated cells	213.5 nTPM
Colon	312.3 nTPM
Small intestine	170.6 nTPM
Rectum	157.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC