Single cell type - EIF3H - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF3H
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 3 subunit H
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EIF3H is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EIF3M	Eukaryotic translation initiation factor 3 subunit M	0.8490	10
EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.8234	10
RPL35	Ribosomal protein L35	0.7890	32
ESD	Esterase D	0.7750	10
EIF3I	Eukaryotic translation initiation factor 3 subunit I	0.7738	10
GSTA5	Glutathione S-transferase alpha 5	0.7716	10
RPL24	Ribosomal protein L24	0.7660	32
POTEM	POTE ankyrin domain family member M	0.7563	10
PARL	Presenilin associated rhomboid like	0.7512	10
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.7482	10
PSMB2	Proteasome 20S subunit beta 2	0.7458	10
TMEM60	Transmembrane protein 60	0.7423	10
RPL27	Ribosomal protein L27	0.7342	32
FCF1	FCF1 rRNA-processing protein	0.7251	10
ANGPTL6	Angiopoietin like 6	0.7187	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	138.9 nTPM
Breast	146.4 nTPM
Adipose tissue	131.5 nTPM

Alveolar cells type 1	182.7 nTPM
Lung	182.7 nTPM

Alveolar cells type 2	210.7 nTPM
Lung	210.7 nTPM

Astrocytes	42.4 nTPM
Brain	42.4 nTPM

B-cells	314.6 nTPM
PBMC	501.1 nTPM
Kidney	419.0 nTPM
Adipose tissue	367.9 nTPM
Colon	338.7 nTPM
Liver	334.4 nTPM
Spleen	266.5 nTPM
Lymph node	258.6 nTPM
Stomach	225.7 nTPM
Bone marrow	223.1 nTPM
Breast	211.4 nTPM

Basal squamous epithelial cells	266.9 nTPM
Esophagus	266.9 nTPM

Dendritic cells	211.4 nTPM
PBMC	259.0 nTPM
Adipose tissue	200.0 nTPM
Breast	175.3 nTPM

Endothelial cells	185.8 nTPM
Prostate	297.3 nTPM
Testis	297.2 nTPM
Skin	286.4 nTPM
Placenta	246.1 nTPM
Pancreas	231.6 nTPM
Breast	224.1 nTPM
Liver	206.3 nTPM
Esophagus	159.2 nTPM
Skeletal muscle	132.5 nTPM
Ovary	130.7 nTPM
Endometrium	112.8 nTPM
Lung	112.3 nTPM
Eye	95.5 nTPM
Heart muscle	69.8 nTPM

Enteroendocrine cells	201.0 nTPM
Colon	227.4 nTPM
Rectum	174.7 nTPM

Erythroid cells	215.8 nTPM
Bone marrow	217.8 nTPM
Liver	213.9 nTPM

Fibroblasts	183.7 nTPM
Lung	275.9 nTPM
Prostate	271.5 nTPM
Placenta	257.2 nTPM
Skin	224.6 nTPM
Ovary	196.4 nTPM
Breast	174.2 nTPM
Adipose tissue	143.4 nTPM
Esophagus	129.2 nTPM
Stomach	124.7 nTPM
Skeletal muscle	116.2 nTPM
Heart muscle	107.2 nTPM

Intestinal goblet cells	301.6 nTPM
Colon	387.4 nTPM
Rectum	329.9 nTPM
Small intestine	187.6 nTPM

Macrophages	261.5 nTPM
Prostate	410.3 nTPM
Testis	407.2 nTPM
Kidney	380.4 nTPM
Adipose tissue	364.1 nTPM
Ovary	325.1 nTPM
Lung	263.9 nTPM
Skeletal muscle	261.4 nTPM
Breast	253.5 nTPM
Spleen	221.9 nTPM
Stomach	211.0 nTPM
Bone marrow	198.7 nTPM
Endometrium	195.8 nTPM
Pancreas	183.7 nTPM
Esophagus	163.6 nTPM
PBMC	81.8 nTPM

Paneth cells	240.5 nTPM
Rectum	356.0 nTPM
Small intestine	214.1 nTPM
Colon	151.5 nTPM

Plasma cells	166.7 nTPM
Spleen	225.4 nTPM
Stomach	173.4 nTPM
Esophagus	160.2 nTPM
Bone marrow	156.5 nTPM
Adipose tissue	118.1 nTPM

Cholangiocytes	191.6 nTPM
Liver	191.6 nTPM

Collecting duct cells	93.8 nTPM
Kidney	93.8 nTPM

Cone photoreceptor cells	12.5 nTPM
Eye	12.5 nTPM

Cytotrophoblasts	488.0 nTPM
Placenta	488.0 nTPM

Respiratory ciliated cells	92.9 nTPM
Lung	107.8 nTPM
Bronchus	78.0 nTPM

Smooth muscle cells	504.1 nTPM
Bronchus	3385.3 nTPM
Prostate	343.0 nTPM
Skin	338.9 nTPM
Breast	263.3 nTPM
Pancreas	261.8 nTPM
Ovary	224.2 nTPM
Adipose tissue	178.8 nTPM
Esophagus	172.1 nTPM
Skeletal muscle	158.6 nTPM
Endometrium	125.9 nTPM
Heart muscle	93.6 nTPM

T-cells	287.5 nTPM
PBMC	669.0 nTPM
Kidney	381.9 nTPM
Liver	357.3 nTPM
Lymph node	331.3 nTPM
Skin	327.4 nTPM
Prostate	326.6 nTPM
Colon	316.4 nTPM
Adipose tissue	294.2 nTPM
Ovary	249.1 nTPM
Spleen	243.4 nTPM
Breast	232.4 nTPM
Stomach	225.1 nTPM
Lung	208.0 nTPM
Skeletal muscle	206.5 nTPM
Bone marrow	196.0 nTPM
Esophagus	176.9 nTPM
Endometrium	145.7 nTPM

Undifferentiated cells	345.5 nTPM
Small intestine	353.1 nTPM
Colon	345.7 nTPM
Rectum	337.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC