Single cell type - MGST2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MGST2
Gene descriptionⁱ Full gene name according to HGNC.	Microsomal glutathione S-transferase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MGST2 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EHF	ETS homologous factor	0.5770	22
THEM6	Thioesterase superfamily member 6	0.5585	30
FZD6	Frizzled class receptor 6	0.5503	44
MPZL2	Myelin protein zero like 2	0.5494	22
CD9	CD9 molecule	0.5241	26
ID1	Inhibitor of DNA binding 1, HLH protein	0.5191	14
SLC7A1	Solute carrier family 7 member 1	0.5174	61
PRRG4	Proline rich and Gla domain 4	0.5058	22
PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma	0.5052	16
ADGRG6	Adhesion G protein-coupled receptor G6	0.4894	15
S100A2	S100 calcium binding protein A2	0.4863	26
IFNE	Interferon epsilon	0.4764	22
GJB5	Gap junction protein beta 5	0.4694	61
CCL14	C-C motif chemokine ligand 14	0.4690	14
LMO2	LIM domain only 2	0.4689	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	327.9 nTPM
Adipose tissue	336.4 nTPM
Breast	319.3 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	36.6 nTPM
Lung	36.6 nTPM

Astrocytes	5.5 nTPM
Brain	5.5 nTPM

B-cells	7.7 nTPM
Kidney	23.8 nTPM
Liver	20.8 nTPM
Breast	13.4 nTPM
Colon	9.6 nTPM
Spleen	2.1 nTPM
Lymph node	1.9 nTPM
Bone marrow	1.7 nTPM
PBMC	1.4 nTPM
Stomach	1.4 nTPM
Adipose tissue	0.5 nTPM

Dendritic cells	71.0 nTPM
PBMC	187.3 nTPM
Breast	14.9 nTPM
Adipose tissue	10.8 nTPM

Endothelial cells	238.4 nTPM
Testis	444.4 nTPM
Placenta	377.4 nTPM
Prostate	334.3 nTPM
Breast	290.7 nTPM
Pancreas	274.1 nTPM
Esophagus	263.7 nTPM
Skin	245.6 nTPM
Ovary	225.7 nTPM
Skeletal muscle	216.2 nTPM
Lung	193.4 nTPM
Endometrium	146.8 nTPM
Heart muscle	130.5 nTPM
Liver	103.7 nTPM
Eye	91.4 nTPM

Enteroendocrine cells	121.8 nTPM
Rectum	133.5 nTPM
Colon	110.1 nTPM

Fibroblasts	31.8 nTPM
Placenta	55.5 nTPM
Stomach	44.6 nTPM
Adipose tissue	35.2 nTPM
Skin	33.1 nTPM
Heart muscle	33.0 nTPM
Breast	31.3 nTPM
Skeletal muscle	28.7 nTPM
Ovary	24.1 nTPM
Lung	23.4 nTPM
Prostate	20.9 nTPM
Esophagus	20.6 nTPM

Intestinal goblet cells	215.1 nTPM
Colon	289.5 nTPM
Small intestine	191.0 nTPM
Rectum	164.8 nTPM

Macrophages	85.3 nTPM
Prostate	150.2 nTPM
Kidney	143.7 nTPM
Testis	122.5 nTPM
Ovary	120.0 nTPM
Pancreas	109.7 nTPM
Breast	99.9 nTPM
Endometrium	90.2 nTPM
Stomach	73.3 nTPM
Adipose tissue	71.4 nTPM
Esophagus	67.7 nTPM
Skeletal muscle	66.0 nTPM
Spleen	64.3 nTPM
Lung	61.7 nTPM
Bone marrow	38.8 nTPM
PBMC	0.0 nTPM

Paneth cells	213.1 nTPM
Small intestine	255.4 nTPM
Rectum	226.0 nTPM
Colon	158.1 nTPM

Plasma cells	7.1 nTPM
Esophagus	12.3 nTPM
Adipose tissue	10.3 nTPM
Stomach	5.0 nTPM
Spleen	4.5 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	126.6 nTPM
Bronchus	190.4 nTPM
Lung	62.7 nTPM

Smooth muscle cells	49.6 nTPM
Bronchus	67.6 nTPM
Breast	65.5 nTPM
Skin	65.2 nTPM
Esophagus	63.6 nTPM
Prostate	54.4 nTPM
Heart muscle	50.7 nTPM
Ovary	46.1 nTPM
Adipose tissue	44.8 nTPM
Endometrium	41.9 nTPM
Skeletal muscle	29.6 nTPM
Pancreas	15.8 nTPM

Basal keratinocytes	61.1 nTPM
Skin	61.1 nTPM

Basal prostatic cells	295.9 nTPM
Prostate	295.9 nTPM

Basal respiratory cells	316.7 nTPM
Bronchus	316.7 nTPM

Basal squamous epithelial cells	75.7 nTPM
Esophagus	75.7 nTPM

T-cells	15.2 nTPM
Prostate	52.1 nTPM
Skin	29.9 nTPM
Liver	29.8 nTPM
Endometrium	29.6 nTPM
Kidney	24.7 nTPM
Lung	19.7 nTPM
Colon	15.2 nTPM
Breast	11.9 nTPM
PBMC	7.4 nTPM
Adipose tissue	7.0 nTPM
Skeletal muscle	6.7 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Lymph node	3.5 nTPM
Spleen	3.3 nTPM
Bone marrow	2.8 nTPM
Stomach	2.3 nTPM

Undifferentiated cells	258.2 nTPM
Colon	291.5 nTPM
Small intestine	273.4 nTPM
Rectum	209.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC