Single cell type - MPZL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPZL2
Gene descriptionⁱ Full gene name according to HGNC.	Myelin protein zero like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal prostatic cells, Urothelial cells, Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Basal respiratory cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (myeloid DC, neutrophil, classical monocyte, intermediate monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, EFO-21, HaCaT, RT4, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal prostatic cells, Urothelial cells, Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Basal respiratory cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPZL2 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RAET1L	Retinoic acid early transcript 1L	0.8913	22
TACSTD2	Tumor associated calcium signal transducer 2	0.8462	22
WNT7B	Wnt family member 7B	0.7858	22
CLDN1	Claudin 1	0.7817	22
GJB5	Gap junction protein beta 5	0.7798	61
PRRG4	Proline rich and Gla domain 4	0.7796	22
IRF6	Interferon regulatory factor 6	0.7650	22
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.7559	22
KLF5	Kruppel like factor 5	0.7462	22
IFNE	Interferon epsilon	0.7432	22
EHF	ETS homologous factor	0.7389	22
GJB3	Gap junction protein beta 3	0.7338	22
S100A2	S100 calcium binding protein A2	0.7283	26
FAM110C	Family with sequence similarity 110 member C	0.7258	22
GPR87	G protein-coupled receptor 87	0.7216	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.9 nTPM
Adipose tissue	9.0 nTPM
Breast	2.9 nTPM

Alveolar cells type 1	83.3 nTPM
Lung	83.3 nTPM

Alveolar cells type 2	123.3 nTPM
Lung	123.3 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	0.2 nTPM
Colon	1.6 nTPM
Stomach	0.5 nTPM
Liver	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Breast	0.0 nTPM

Basal squamous epithelial cells	127.5 nTPM
Esophagus	127.5 nTPM

Dendritic cells	0.5 nTPM
Breast	1.1 nTPM
Adipose tissue	0.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	33.6 nTPM
Prostate	115.8 nTPM
Liver	72.4 nTPM
Esophagus	55.5 nTPM
Placenta	39.3 nTPM
Endometrium	32.5 nTPM
Lung	31.2 nTPM
Skin	29.1 nTPM
Testis	24.0 nTPM
Heart muscle	19.9 nTPM
Skeletal muscle	16.3 nTPM
Breast	12.8 nTPM
Eye	11.3 nTPM
Ovary	6.8 nTPM
Pancreas	3.9 nTPM

Fibroblasts	8.2 nTPM
Stomach	37.1 nTPM
Prostate	17.5 nTPM
Skin	16.3 nTPM
Lung	7.8 nTPM
Placenta	4.7 nTPM
Heart muscle	3.9 nTPM
Esophagus	2.1 nTPM
Breast	1.1 nTPM
Skeletal muscle	0.2 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM

Intestinal goblet cells	6.3 nTPM
Rectum	10.3 nTPM
Small intestine	6.3 nTPM
Colon	2.2 nTPM

Macrophages	7.8 nTPM
Lung	28.8 nTPM
Prostate	20.7 nTPM
Endometrium	18.5 nTPM
Testis	11.7 nTPM
Esophagus	11.0 nTPM
Spleen	5.2 nTPM
Ovary	4.5 nTPM
Adipose tissue	3.7 nTPM
Kidney	3.0 nTPM
Stomach	2.9 nTPM
Breast	2.6 nTPM
Skeletal muscle	2.5 nTPM
Bone marrow	2.5 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	20.8 nTPM
Colon	46.1 nTPM
Rectum	16.4 nTPM
Small intestine	0.0 nTPM

Plasma cells	1.2 nTPM
Esophagus	6.1 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	65.2 nTPM
Bronchus	79.3 nTPM
Lung	51.0 nTPM

Smooth muscle cells	9.2 nTPM
Bronchus	60.2 nTPM
Prostate	23.1 nTPM
Skin	8.0 nTPM
Endometrium	5.6 nTPM
Heart muscle	1.8 nTPM
Breast	1.0 nTPM
Pancreas	0.6 nTPM
Skeletal muscle	0.3 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Cholangiocytes	30.0 nTPM
Liver	30.0 nTPM

Collecting duct cells	128.8 nTPM
Kidney	128.8 nTPM

Cytotrophoblasts	1.7 nTPM
Placenta	1.7 nTPM

Distal enterocytes	52.0 nTPM
Colon	53.8 nTPM
Rectum	50.3 nTPM

T-cells	5.4 nTPM
Skin	28.5 nTPM
Prostate	28.4 nTPM
Endometrium	19.6 nTPM
Liver	3.3 nTPM
Colon	2.9 nTPM
Breast	2.7 nTPM
PBMC	1.8 nTPM
Lung	1.5 nTPM
Kidney	1.4 nTPM
Adipose tissue	0.7 nTPM
Spleen	0.7 nTPM
Stomach	0.4 nTPM
Bone marrow	0.1 nTPM
Skeletal muscle	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM

Undifferentiated cells	33.4 nTPM
Colon	41.9 nTPM
Rectum	39.6 nTPM
Small intestine	18.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC