Single cell type - AAAS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AAAS
Gene descriptionⁱ Full gene name according to HGNC.	Aladin WD repeat nucleoporin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AAAS is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ANGPTL6	Angiopoietin like 6	0.8130	10
COPS6	COP9 signalosome subunit 6	0.8069	10
ESD	Esterase D	0.8031	10
GSTA5	Glutathione S-transferase alpha 5	0.7988	10
ZMAT5	Zinc finger matrin-type 5	0.7749	10
FCF1	FCF1 rRNA-processing protein	0.7735	10
NUP85	Nucleoporin 85	0.7663	10
POTEM	POTE ankyrin domain family member M	0.7512	10
PARL	Presenilin associated rhomboid like	0.7496	10
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.7432	10
TMEM60	Transmembrane protein 60	0.7412	10
PSMB2	Proteasome 20S subunit beta 2	0.7393	10
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.7327	10
HTRA2	HtrA serine peptidase 2	0.7271	10
RCE1	Ras converting CAAX endopeptidase 1	0.7247	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.7 nTPM
Breast	13.3 nTPM
Adipose tissue	10.0 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	7.8 nTPM
Lung	7.8 nTPM

Astrocytes	17.9 nTPM
Brain	17.9 nTPM

B-cells	15.1 nTPM
Liver	34.3 nTPM
Bone marrow	23.7 nTPM
Kidney	19.0 nTPM
Stomach	15.9 nTPM
Breast	14.7 nTPM
Lymph node	13.3 nTPM
Spleen	11.8 nTPM
PBMC	9.9 nTPM
Adipose tissue	5.5 nTPM
Colon	3.2 nTPM

Dendritic cells	13.7 nTPM
PBMC	16.0 nTPM
Breast	16.0 nTPM
Adipose tissue	9.0 nTPM

Endothelial cells	11.7 nTPM
Placenta	29.0 nTPM
Pancreas	19.3 nTPM
Testis	14.5 nTPM
Ovary	12.7 nTPM
Liver	11.0 nTPM
Breast	10.6 nTPM
Eye	10.5 nTPM
Endometrium	10.3 nTPM
Lung	9.3 nTPM
Heart muscle	8.8 nTPM
Skeletal muscle	7.7 nTPM
Prostate	7.4 nTPM
Skin	6.8 nTPM
Esophagus	5.2 nTPM

Fibroblasts	14.9 nTPM
Placenta	37.1 nTPM
Ovary	20.5 nTPM
Breast	18.0 nTPM
Adipose tissue	15.9 nTPM
Esophagus	15.8 nTPM
Heart muscle	14.1 nTPM
Skeletal muscle	11.0 nTPM
Stomach	10.4 nTPM
Skin	9.8 nTPM
Prostate	8.4 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	13.1 nTPM
Rectum	14.7 nTPM
Colon	12.9 nTPM
Small intestine	11.7 nTPM

Macrophages	10.6 nTPM
Bone marrow	17.5 nTPM
Breast	16.1 nTPM
Esophagus	15.8 nTPM
Testis	14.0 nTPM
Kidney	13.7 nTPM
Ovary	13.5 nTPM
Pancreas	12.8 nTPM
Stomach	11.7 nTPM
Endometrium	11.3 nTPM
Adipose tissue	9.6 nTPM
Lung	9.4 nTPM
Skeletal muscle	7.8 nTPM
Spleen	3.1 nTPM
Prostate	2.2 nTPM
PBMC	0.0 nTPM

Paneth cells	11.0 nTPM
Small intestine	15.0 nTPM
Rectum	14.9 nTPM
Colon	3.3 nTPM

Plasma cells	20.8 nTPM
Bone marrow	41.2 nTPM
Stomach	26.7 nTPM
Spleen	24.3 nTPM
Esophagus	6.1 nTPM
Adipose tissue	5.8 nTPM

Respiratory ciliated cells	12.6 nTPM
Bronchus	18.0 nTPM
Lung	7.3 nTPM

Smooth muscle cells	39.7 nTPM
Bronchus	282.6 nTPM
Pancreas	25.8 nTPM
Breast	21.3 nTPM
Esophagus	17.0 nTPM
Adipose tissue	16.1 nTPM
Ovary	15.7 nTPM
Skeletal muscle	14.9 nTPM
Endometrium	12.8 nTPM
Skin	12.6 nTPM
Prostate	11.0 nTPM
Heart muscle	6.7 nTPM

T-cells	11.4 nTPM
Kidney	19.8 nTPM
Bone marrow	17.1 nTPM
Liver	15.6 nTPM
Spleen	15.6 nTPM
PBMC	15.0 nTPM
Stomach	13.9 nTPM
Lymph node	13.6 nTPM
Skin	13.3 nTPM
Breast	12.9 nTPM
Colon	9.5 nTPM
Lung	9.1 nTPM
Endometrium	7.0 nTPM
Skeletal muscle	6.7 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Adipose tissue	6.5 nTPM
Prostate	4.7 nTPM

Basal respiratory cells	26.2 nTPM
Bronchus	26.2 nTPM

Basal squamous epithelial cells	10.2 nTPM
Esophagus	10.2 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Undifferentiated cells	17.2 nTPM
Small intestine	20.1 nTPM
Rectum	16.0 nTPM
Colon	15.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC