Single cell type - HTRA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HTRA2
Gene descriptionⁱ Full gene name according to HGNC.	HtrA serine peptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HTRA2 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GSTA5	Glutathione S-transferase alpha 5	0.7369	10
UBB	Ubiquitin B	0.7347	10
AAAS	Aladin WD repeat nucleoporin	0.7271	10
POTEM	POTE ankyrin domain family member M	0.7223	10
ESD	Esterase D	0.7080	10
ANGPTL6	Angiopoietin like 6	0.7019	10
HMGA2	High mobility group AT-hook 2	0.6853	10
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.6846	10
FCF1	FCF1 rRNA-processing protein	0.6679	10
UROD	Uroporphyrinogen decarboxylase	0.6637	6
GNG8	G protein subunit gamma 8	0.6626	10
CCT5	Chaperonin containing TCP1 subunit 5	0.6601	10
COPS6	COP9 signalosome subunit 6	0.6561	10
PTTG2	Pituitary tumor-transforming 2	0.6463	10
PPT2	Palmitoyl-protein thioesterase 2	0.6446	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.7 nTPM
Breast	34.9 nTPM
Adipose tissue	26.5 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	4.8 nTPM
Lung	4.8 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	27.3 nTPM
Liver	37.8 nTPM
Colon	35.1 nTPM
Bone marrow	31.1 nTPM
Kidney	28.5 nTPM
Breast	28.1 nTPM
Adipose tissue	25.1 nTPM
Stomach	24.1 nTPM
Lymph node	23.5 nTPM
Spleen	21.5 nTPM
PBMC	18.6 nTPM

Dendritic cells	25.8 nTPM
Breast	32.8 nTPM
Adipose tissue	24.6 nTPM
PBMC	20.0 nTPM

Endothelial cells	29.6 nTPM
Pancreas	54.0 nTPM
Prostate	44.6 nTPM
Liver	42.2 nTPM
Skin	34.9 nTPM
Placenta	34.7 nTPM
Esophagus	33.4 nTPM
Testis	32.0 nTPM
Breast	30.8 nTPM
Skeletal muscle	29.9 nTPM
Ovary	25.4 nTPM
Endometrium	21.2 nTPM
Eye	17.8 nTPM
Lung	12.5 nTPM
Heart muscle	1.4 nTPM

Erythroid cells	118.5 nTPM
Liver	192.5 nTPM
Bone marrow	44.6 nTPM

Fibroblasts	23.3 nTPM
Placenta	35.7 nTPM
Prostate	30.2 nTPM
Adipose tissue	29.8 nTPM
Skin	28.3 nTPM
Esophagus	27.5 nTPM
Breast	27.0 nTPM
Skeletal muscle	25.9 nTPM
Ovary	19.5 nTPM
Stomach	19.3 nTPM
Lung	13.4 nTPM
Heart muscle	0.2 nTPM

Intestinal goblet cells	12.3 nTPM
Rectum	14.3 nTPM
Small intestine	13.3 nTPM
Colon	9.3 nTPM

Macrophages	14.6 nTPM
PBMC	27.3 nTPM
Ovary	24.1 nTPM
Pancreas	23.0 nTPM
Prostate	20.7 nTPM
Breast	20.1 nTPM
Testis	19.7 nTPM
Kidney	14.3 nTPM
Esophagus	12.6 nTPM
Skeletal muscle	10.2 nTPM
Lung	9.6 nTPM
Adipose tissue	9.6 nTPM
Stomach	8.8 nTPM
Endometrium	8.2 nTPM
Spleen	7.2 nTPM
Bone marrow	3.7 nTPM

Paneth cells	16.8 nTPM
Colon	19.7 nTPM
Rectum	15.7 nTPM
Small intestine	15.0 nTPM

Plasma cells	36.0 nTPM
Esophagus	55.5 nTPM
Stomach	41.1 nTPM
Spleen	33.6 nTPM
Adipose tissue	28.5 nTPM
Bone marrow	21.4 nTPM

Respiratory ciliated cells	13.5 nTPM
Bronchus	16.8 nTPM
Lung	10.2 nTPM

Smooth muscle cells	56.5 nTPM
Bronchus	396.7 nTPM
Pancreas	32.9 nTPM
Prostate	32.1 nTPM
Skin	26.5 nTPM
Ovary	25.6 nTPM
Breast	25.1 nTPM
Adipose tissue	21.8 nTPM
Skeletal muscle	21.6 nTPM
Endometrium	20.4 nTPM
Esophagus	18.6 nTPM
Heart muscle	0.5 nTPM

Basal keratinocytes	20.6 nTPM
Skin	20.6 nTPM

Basal respiratory cells	33.8 nTPM
Bronchus	33.8 nTPM

Basal squamous epithelial cells	13.6 nTPM
Esophagus	13.6 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

T-cells	20.6 nTPM
Kidney	32.2 nTPM
Prostate	28.4 nTPM
Skin	28.1 nTPM
Breast	27.8 nTPM
Colon	25.2 nTPM
Liver	25.1 nTPM
PBMC	22.5 nTPM
Bone marrow	21.9 nTPM
Adipose tissue	19.5 nTPM
Stomach	19.3 nTPM
Spleen	18.6 nTPM
Lymph node	17.7 nTPM
Endometrium	17.4 nTPM
Skeletal muscle	14.7 nTPM
Lung	13.6 nTPM
Ovary	11.1 nTPM
Esophagus	6.6 nTPM

Undifferentiated cells	20.0 nTPM
Small intestine	23.5 nTPM
Rectum	20.1 nTPM
Colon	16.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC