Single cell type - BCAS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCAS2
Gene descriptionⁱ Full gene name according to HGNC.	BCAS2 pre-mRNA processing factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BCAS2 is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ERN1	Endoplasmic reticulum to nucleus signaling 1	0.6951	55
DDIT4	DNA damage inducible transcript 4	0.6765	22
CLK1	CDC like kinase 1	0.6556	22
EIF4A3	Eukaryotic translation initiation factor 4A3	0.6250	7
GTF2B	General transcription factor IIB	0.6195	7
UBC	Ubiquitin C	0.6109	7
PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component	0.5928	24
ANKRD37	Ankyrin repeat domain 37	0.5881	26
SLC3A2	Solute carrier family 3 member 2	0.5804	26
IL2	Interleukin 2	0.5773	7
RGS1	Regulator of G protein signaling 1	0.5738	41
DNAJB1	DnaJ heat shock protein family (Hsp40) member B1	0.5701	22
PPP1R15A	Protein phosphatase 1 regulatory subunit 15A	0.5692	7
ALG13	ALG13 UDP-N-acetylglucosaminyltransferase subunit	0.5633	24
TNFAIP3	TNF alpha induced protein 3	0.5566	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	51.6 nTPM
Breast	53.4 nTPM
Adipose tissue	49.8 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	45.4 nTPM
Lung	45.4 nTPM

Astrocytes	11.1 nTPM
Brain	11.1 nTPM

B-cells	110.1 nTPM
Adipose tissue	234.1 nTPM
Breast	169.9 nTPM
Colon	139.0 nTPM
Stomach	138.5 nTPM
Spleen	101.1 nTPM
Lymph node	82.3 nTPM
Kidney	76.1 nTPM
Liver	66.7 nTPM
PBMC	60.0 nTPM
Bone marrow	33.5 nTPM

Dendritic cells	99.0 nTPM
Adipose tissue	116.3 nTPM
Breast	113.0 nTPM
PBMC	67.8 nTPM

Endothelial cells	46.9 nTPM
Eye	83.3 nTPM
Skin	63.8 nTPM
Skeletal muscle	52.3 nTPM
Prostate	50.6 nTPM
Pancreas	50.2 nTPM
Testis	47.7 nTPM
Heart muscle	45.7 nTPM
Placenta	45.5 nTPM
Endometrium	45.1 nTPM
Lung	40.6 nTPM
Ovary	38.6 nTPM
Esophagus	34.6 nTPM
Breast	33.2 nTPM
Liver	24.7 nTPM

Fibroblasts	60.0 nTPM
Prostate	160.2 nTPM
Stomach	63.9 nTPM
Adipose tissue	58.9 nTPM
Placenta	57.9 nTPM
Heart muscle	57.7 nTPM
Ovary	52.8 nTPM
Skin	46.5 nTPM
Skeletal muscle	42.9 nTPM
Lung	41.3 nTPM
Breast	41.3 nTPM
Esophagus	37.1 nTPM

Intestinal goblet cells	43.1 nTPM
Colon	62.9 nTPM
Rectum	34.4 nTPM
Small intestine	32.0 nTPM

Macrophages	80.8 nTPM
Adipose tissue	217.7 nTPM
Prostate	213.2 nTPM
Breast	136.6 nTPM
Stomach	99.6 nTPM
Endometrium	71.0 nTPM
Esophagus	69.3 nTPM
Kidney	62.0 nTPM
Spleen	57.0 nTPM
Ovary	56.6 nTPM
Skeletal muscle	51.2 nTPM
Pancreas	51.0 nTPM
Lung	50.3 nTPM
Testis	50.0 nTPM
Bone marrow	26.2 nTPM
PBMC	0.0 nTPM

Paneth cells	37.9 nTPM
Small intestine	56.3 nTPM
Rectum	34.4 nTPM
Colon	23.1 nTPM

Plasma cells	176.7 nTPM
Esophagus	462.0 nTPM
Stomach	181.0 nTPM
Spleen	113.1 nTPM
Adipose tissue	92.9 nTPM
Bone marrow	34.6 nTPM

Respiratory ciliated cells	55.6 nTPM
Bronchus	64.6 nTPM
Lung	46.6 nTPM

Smooth muscle cells	71.4 nTPM
Skin	130.1 nTPM
Prostate	119.5 nTPM
Pancreas	90.5 nTPM
Skeletal muscle	77.1 nTPM
Ovary	62.3 nTPM
Heart muscle	62.0 nTPM
Breast	60.2 nTPM
Adipose tissue	59.5 nTPM
Endometrium	47.0 nTPM
Bronchus	44.2 nTPM
Esophagus	32.5 nTPM

T-cells	117.4 nTPM
Prostate	359.7 nTPM
Breast	213.4 nTPM
Adipose tissue	194.4 nTPM
Colon	131.6 nTPM
Spleen	123.2 nTPM
Endometrium	114.4 nTPM
Stomach	110.9 nTPM
Skin	109.1 nTPM
Lymph node	108.0 nTPM
Ovary	97.9 nTPM
Skeletal muscle	76.9 nTPM
Liver	72.2 nTPM
Kidney	68.5 nTPM
PBMC	62.9 nTPM
Lung	59.2 nTPM
Esophagus	52.4 nTPM
Bone marrow	41.4 nTPM

Basal keratinocytes	77.9 nTPM
Skin	77.9 nTPM

Basal prostatic cells	114.2 nTPM
Prostate	114.2 nTPM

Basal respiratory cells	155.9 nTPM
Bronchus	155.9 nTPM

Basal squamous epithelial cells	91.0 nTPM
Esophagus	91.0 nTPM

Undifferentiated cells	36.0 nTPM
Colon	38.5 nTPM
Small intestine	37.5 nTPM
Rectum	32.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC