Single cell type - PLAT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLAT
Gene descriptionⁱ Full gene name according to HGNC.	Plasminogen activator, tissue type
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Urothelial cells, Basal prostatic cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, HMC-1, hTERT-RPE1, LHCN-M2, U-2197, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Urothelial cells, Basal prostatic cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLAT is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KRT17	Keratin 17	0.8803	22
PDLIM4	PDZ and LIM domain 4	0.8570	22
RNASE7	Ribonuclease A family member 7	0.8423	22
LRRC8A	Leucine rich repeat containing 8 VRAC subunit A	0.8385	22
GJB4	Gap junction protein beta 4	0.8349	22
KRTAP4-12	Keratin associated protein 4-12	0.8262	22
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.8150	22
KRTAP3-1	Keratin associated protein 3-1	0.8148	22
SLC14A1	Solute carrier family 14 member 1 (Kidd blood group)	0.8000	22
PADI3	Peptidyl arginine deiminase 3	0.7917	22
PLAU	Plasminogen activator, urokinase	0.7834	22
PHLDA3	Pleckstrin homology like domain family A member 3	0.7702	22
CXCL8	C-X-C motif chemokine ligand 8	0.7669	22
DKK1	Dickkopf WNT signaling pathway inhibitor 1	0.7665	22
TXNRD1	Thioredoxin reductase 1	0.7646	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	63.5 nTPM
Adipose tissue	100.5 nTPM
Breast	26.6 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	13.7 nTPM
Lung	13.7 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	2.9 nTPM
Kidney	19.0 nTPM
Breast	2.6 nTPM
Liver	2.5 nTPM
Adipose tissue	2.0 nTPM
PBMC	1.4 nTPM
Stomach	0.9 nTPM
Lymph node	0.3 nTPM
Colon	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.9 nTPM
Breast	1.8 nTPM
Adipose tissue	0.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	98.2 nTPM
Eye	303.4 nTPM
Prostate	250.2 nTPM
Lung	143.5 nTPM
Skeletal muscle	130.4 nTPM
Esophagus	119.6 nTPM
Heart muscle	109.9 nTPM
Liver	109.2 nTPM
Skin	78.0 nTPM
Breast	73.6 nTPM
Pancreas	23.1 nTPM
Ovary	12.9 nTPM
Endometrium	11.6 nTPM
Testis	5.9 nTPM
Placenta	3.4 nTPM

Fibroblasts	136.5 nTPM
Stomach	683.1 nTPM
Prostate	416.0 nTPM
Ovary	103.5 nTPM
Esophagus	71.7 nTPM
Adipose tissue	47.7 nTPM
Skeletal muscle	41.2 nTPM
Breast	39.7 nTPM
Lung	38.0 nTPM
Placenta	26.7 nTPM
Heart muscle	25.3 nTPM
Skin	8.8 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	4.7 nTPM
Prostate	26.3 nTPM
Lung	12.7 nTPM
Endometrium	6.8 nTPM
Esophagus	6.3 nTPM
Breast	5.8 nTPM
Adipose tissue	3.7 nTPM
Skeletal muscle	3.1 nTPM
Kidney	3.0 nTPM
Ovary	2.3 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	2.8 nTPM
Adipose tissue	9.7 nTPM
Stomach	3.4 nTPM
Spleen	0.7 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	4.0 nTPM
Lung	5.8 nTPM
Bronchus	2.1 nTPM

Smooth muscle cells	48.3 nTPM
Ovary	144.6 nTPM
Pancreas	111.6 nTPM
Endometrium	107.0 nTPM
Prostate	71.3 nTPM
Skeletal muscle	28.9 nTPM
Heart muscle	18.9 nTPM
Adipose tissue	14.9 nTPM
Breast	11.4 nTPM
Skin	10.5 nTPM
Esophagus	7.8 nTPM
Bronchus	4.7 nTPM

T-cells	6.0 nTPM
Prostate	42.6 nTPM
Endometrium	14.6 nTPM
Lung	9.1 nTPM
Breast	8.9 nTPM
Skeletal muscle	8.7 nTPM
Colon	4.3 nTPM
Kidney	4.2 nTPM
Skin	2.3 nTPM
Stomach	2.3 nTPM
Lymph node	2.0 nTPM
Liver	1.3 nTPM
Adipose tissue	1.2 nTPM
Spleen	0.7 nTPM
PBMC	0.4 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Cholangiocytes	1.5 nTPM
Liver	1.5 nTPM

Cytotrophoblasts	0.6 nTPM
Placenta	0.6 nTPM

Endometrial stromal cells	104.2 nTPM
Endometrium	104.2 nTPM

Excitatory neurons	1.6 nTPM
Brain	1.6 nTPM

Undifferentiated cells	0.5 nTPM
Colon	1.0 nTPM
Small intestine	0.4 nTPM
Rectum	0.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC