Single cell type - FOSL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FOSL1
Gene descriptionⁱ Full gene name according to HGNC.	FOS like 1, AP-1 transcription factor subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Metabolic proteins Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Urothelial cells, Basal prostatic cells, Suprabasal keratinocytes, Basal keratinocytes, Basal squamous epithelial cells, Squamous epithelial cells, Prostatic glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (myeloid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (PC-3, U-2197, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Urothelial cells, Basal prostatic cells, Suprabasal keratinocytes, Basal keratinocytes, Basal squamous epithelial cells, Squamous epithelial cells, Prostatic glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FOSL1 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KRT17	Keratin 17	0.8639	22
RNASE7	Ribonuclease A family member 7	0.8533	22
KRTAP3-1	Keratin associated protein 3-1	0.8395	22
KRTAP4-12	Keratin associated protein 4-12	0.8176	22
PLAT	Plasminogen activator, tissue type	0.8150	22
ERRFI1	ERBB receptor feedback inhibitor 1	0.8100	22
CLDN1	Claudin 1	0.8065	22
RAET1L	Retinoic acid early transcript 1L	0.7966	22
GADD45A	Growth arrest and DNA damage inducible alpha	0.7940	22
GJB4	Gap junction protein beta 4	0.7938	22
CXCL8	C-X-C motif chemokine ligand 8	0.7878	22
LRRC8A	Leucine rich repeat containing 8 VRAC subunit A	0.7865	22
KRT16	Keratin 16	0.7850	28
BCAR3	BCAR3 adaptor protein, NSP family member	0.7840	22
GJB3	Gap junction protein beta 3	0.7774	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	15.2 nTPM
Adipose tissue	27.0 nTPM
Breast	3.4 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	4.4 nTPM
Lung	4.4 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	2.0 nTPM
Colon	6.4 nTPM
Breast	5.3 nTPM
Stomach	3.7 nTPM
Adipose tissue	2.5 nTPM
Lymph node	1.9 nTPM
Liver	0.4 nTPM
Spleen	0.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal squamous epithelial cells	281.1 nTPM
Esophagus	281.1 nTPM

Dendritic cells	4.3 nTPM
Breast	10.2 nTPM
Adipose tissue	2.6 nTPM
PBMC	0.0 nTPM

Endothelial cells	30.1 nTPM
Prostate	148.6 nTPM
Skin	88.7 nTPM
Pancreas	65.6 nTPM
Lung	28.1 nTPM
Skeletal muscle	24.7 nTPM
Endometrium	18.6 nTPM
Esophagus	11.3 nTPM
Breast	10.2 nTPM
Eye	8.9 nTPM
Placenta	6.2 nTPM
Liver	5.5 nTPM
Ovary	2.7 nTPM
Heart muscle	1.9 nTPM
Testis	0.6 nTPM

Fibroblasts	45.8 nTPM
Prostate	231.3 nTPM
Skin	81.9 nTPM
Lung	72.6 nTPM
Stomach	60.9 nTPM
Skeletal muscle	28.0 nTPM
Adipose tissue	11.4 nTPM
Esophagus	8.2 nTPM
Placenta	4.7 nTPM
Heart muscle	2.5 nTPM
Breast	1.5 nTPM
Ovary	0.2 nTPM

Intestinal goblet cells	6.8 nTPM
Colon	17.9 nTPM
Small intestine	1.4 nTPM
Rectum	1.1 nTPM

Macrophages	15.5 nTPM
Adipose tissue	55.3 nTPM
Stomach	43.9 nTPM
Esophagus	28.3 nTPM
Prostate	26.3 nTPM
Spleen	21.8 nTPM
Skeletal muscle	17.5 nTPM
Breast	11.0 nTPM
Endometrium	10.9 nTPM
Lung	7.8 nTPM
Pancreas	5.1 nTPM
Testis	1.7 nTPM
Bone marrow	1.2 nTPM
Ovary	1.0 nTPM
Kidney	0.8 nTPM
PBMC	0.0 nTPM

Paneth cells	11.1 nTPM
Colon	32.9 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Plasma cells	6.2 nTPM
Esophagus	12.3 nTPM
Adipose tissue	9.1 nTPM
Stomach	8.1 nTPM
Spleen	1.6 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	10.7 nTPM
Bronchus	11.1 nTPM
Lung	10.2 nTPM

Smooth muscle cells	26.1 nTPM
Prostate	97.5 nTPM
Bronchus	61.5 nTPM
Pancreas	47.3 nTPM
Skin	39.1 nTPM
Skeletal muscle	11.4 nTPM
Adipose tissue	10.2 nTPM
Endometrium	7.6 nTPM
Ovary	5.5 nTPM
Esophagus	4.6 nTPM
Breast	1.7 nTPM
Heart muscle	0.5 nTPM

Cytotrophoblasts	1.3 nTPM
Placenta	1.3 nTPM

Distal enterocytes	11.8 nTPM
Colon	22.7 nTPM
Rectum	0.9 nTPM

Endometrial stromal cells	12.2 nTPM
Endometrium	12.2 nTPM

Excitatory neurons	0.1 nTPM
Brain	0.1 nTPM

T-cells	6.8 nTPM
Prostate	33.1 nTPM
Esophagus	26.2 nTPM
Skin	18.5 nTPM
Breast	9.5 nTPM
Endometrium	8.3 nTPM
Adipose tissue	6.0 nTPM
Skeletal muscle	3.5 nTPM
Spleen	2.7 nTPM
Stomach	2.6 nTPM
Lymph node	2.1 nTPM
Colon	1.9 nTPM
Lung	1.5 nTPM
Bone marrow	0.4 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM

Undifferentiated cells	4.2 nTPM
Colon	11.4 nTPM
Small intestine	0.6 nTPM
Rectum	0.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC