Single cell type - TIMMDC1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TIMMDC1
Gene descriptionⁱ Full gene name according to HGNC.	Translocase of inner mitochondrial membrane domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TIMMDC1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PDHB	Pyruvate dehydrogenase E1 subunit beta	0.6895	39
DLD	Dihydrolipoamide dehydrogenase	0.6329	39
NDUFB5	NADH:ubiquinone oxidoreductase subunit B5	0.6092	39
NFU1	NFU1 iron-sulfur cluster scaffold	0.5977	39
ECH1	Enoyl-CoA hydratase 1	0.5933	47
UQCRFS1	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.5903	39
LDHB	Lactate dehydrogenase B	0.5720	39
HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.5691	54
MRPL13	Mitochondrial ribosomal protein L13	0.5527	26
NDUFA4	NDUFA4 mitochondrial complex associated	0.5467	39
UQCR10	Ubiquinol-cytochrome c reductase, complex III subunit X	0.5452	39
MGST3	Microsomal glutathione S-transferase 3	0.5450	47
NDUFB2	NADH:ubiquinone oxidoreductase subunit B2	0.5371	39
PHYH	Phytanoyl-CoA 2-hydroxylase	0.5367	67
OCIAD1	OCIA domain containing 1	0.5350	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	61.2 nTPM
Breast	74.8 nTPM
Adipose tissue	47.7 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	39.3 nTPM
Lung	39.3 nTPM

Astrocytes	18.6 nTPM
Brain	18.6 nTPM

B-cells	24.0 nTPM
Liver	45.2 nTPM
Breast	34.7 nTPM
Stomach	28.2 nTPM
Bone marrow	27.0 nTPM
PBMC	24.3 nTPM
Spleen	22.2 nTPM
Adipose tissue	20.6 nTPM
Colon	19.2 nTPM
Lymph node	19.0 nTPM
Kidney	0.0 nTPM

Dendritic cells	28.9 nTPM
PBMC	35.8 nTPM
Breast	35.0 nTPM
Adipose tissue	15.8 nTPM

Endothelial cells	56.0 nTPM
Pancreas	84.9 nTPM
Testis	75.0 nTPM
Placenta	73.3 nTPM
Prostate	63.8 nTPM
Skin	60.8 nTPM
Breast	57.1 nTPM
Eye	53.4 nTPM
Liver	52.2 nTPM
Lung	46.8 nTPM
Ovary	46.7 nTPM
Heart muscle	44.7 nTPM
Endometrium	44.7 nTPM
Esophagus	41.8 nTPM
Skeletal muscle	39.1 nTPM

Fibroblasts	48.2 nTPM
Placenta	81.6 nTPM
Heart muscle	57.5 nTPM
Breast	54.1 nTPM
Adipose tissue	54.0 nTPM
Ovary	47.8 nTPM
Esophagus	43.5 nTPM
Stomach	43.0 nTPM
Skin	42.8 nTPM
Skeletal muscle	39.9 nTPM
Prostate	34.9 nTPM
Lung	31.3 nTPM

Intestinal goblet cells	43.5 nTPM
Rectum	46.5 nTPM
Colon	43.6 nTPM
Small intestine	40.2 nTPM

Macrophages	39.4 nTPM
Pancreas	71.5 nTPM
Lung	57.6 nTPM
Ovary	53.3 nTPM
Testis	48.7 nTPM
Kidney	46.8 nTPM
Breast	45.6 nTPM
Esophagus	44.1 nTPM
Spleen	40.4 nTPM
Endometrium	37.6 nTPM
Stomach	32.2 nTPM
Skeletal muscle	30.4 nTPM
Bone marrow	30.0 nTPM
Adipose tissue	27.0 nTPM
Prostate	26.3 nTPM
PBMC	0.0 nTPM

Paneth cells	40.9 nTPM
Small intestine	48.8 nTPM
Rectum	44.3 nTPM
Colon	29.6 nTPM

Plasma cells	30.2 nTPM
Spleen	45.1 nTPM
Stomach	39.5 nTPM
Bone marrow	36.2 nTPM
Esophagus	18.4 nTPM
Adipose tissue	11.6 nTPM

Respiratory ciliated cells	63.0 nTPM
Lung	67.0 nTPM
Bronchus	59.0 nTPM

Smooth muscle cells	52.5 nTPM
Pancreas	98.1 nTPM
Heart muscle	93.4 nTPM
Breast	63.9 nTPM
Adipose tissue	45.5 nTPM
Skin	43.6 nTPM
Skeletal muscle	42.2 nTPM
Ovary	41.7 nTPM
Prostate	40.3 nTPM
Esophagus	38.8 nTPM
Bronchus	35.5 nTPM
Endometrium	34.6 nTPM

T-cells	29.7 nTPM
Ovary	51.2 nTPM
Prostate	47.3 nTPM
Breast	37.7 nTPM
Kidney	35.6 nTPM
Lung	33.4 nTPM
Bone marrow	31.5 nTPM
PBMC	30.8 nTPM
Liver	29.7 nTPM
Skin	29.5 nTPM
Stomach	28.7 nTPM
Endometrium	24.8 nTPM
Spleen	24.5 nTPM
Skeletal muscle	22.9 nTPM
Lymph node	20.8 nTPM
Colon	20.5 nTPM
Esophagus	19.7 nTPM
Adipose tissue	16.7 nTPM

Basal keratinocytes	37.5 nTPM
Skin	37.5 nTPM

Basal prostatic cells	50.4 nTPM
Prostate	50.4 nTPM

Basal respiratory cells	110.2 nTPM
Bronchus	110.2 nTPM

Cholangiocytes	41.5 nTPM
Liver	41.5 nTPM

Undifferentiated cells	45.7 nTPM
Rectum	52.8 nTPM
Small intestine	43.0 nTPM
Colon	41.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC