Single cell type - ABTB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABTB1
Gene descriptionⁱ Full gene name according to HGNC.	Ankyrin repeat and BTB domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes & Neutrophils - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABTB1 is part of cluster 19 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CTDSP1	CTD small phosphatase 1	0.6019	63
YPEL3	Yippee like 3	0.5599	6
LBH	LBH regulator of WNT signaling pathway	0.5374	48
RASGRP2	RAS guanyl releasing protein 2	0.5217	57
CEACAM4	CEA cell adhesion molecule 4	0.5098	19
TNFSF12	TNF superfamily member 12	0.4993	7
HACD4	3-hydroxyacyl-CoA dehydratase 4	0.4992	51
GPSM3	G protein signaling modulator 3	0.4974	63
ARHGDIB	Rho GDP dissociation inhibitor beta	0.4944	63
CMPK2	Cytidine/uridine monophosphate kinase 2	0.4900	6
BORCS6	BLOC-1 related complex subunit 6	0.4836	51
NFE2	Nuclear factor, erythroid 2	0.4810	6
RGS19	Regulator of G protein signaling 19	0.4752	57
CD1D	CD1d molecule	0.4746	57
LRRC25	Leucine rich repeat containing 25	0.4660	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	45.3 nTPM
Breast	50.3 nTPM
Adipose tissue	40.3 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	13.0 nTPM
Lung	13.0 nTPM

Astrocytes	10.7 nTPM
Brain	10.7 nTPM

B-cells	31.7 nTPM
Breast	42.8 nTPM
Lymph node	40.2 nTPM
PBMC	38.6 nTPM
Kidney	38.1 nTPM
Spleen	36.0 nTPM
Bone marrow	35.1 nTPM
Stomach	32.7 nTPM
Adipose tissue	23.6 nTPM
Colon	17.6 nTPM
Liver	12.7 nTPM

Dendritic cells	34.2 nTPM
Breast	58.0 nTPM
Adipose tissue	36.7 nTPM
PBMC	8.0 nTPM

Endothelial cells	20.8 nTPM
Skeletal muscle	44.1 nTPM
Breast	38.4 nTPM
Eye	31.6 nTPM
Testis	27.2 nTPM
Pancreas	23.1 nTPM
Esophagus	22.3 nTPM
Heart muscle	21.4 nTPM
Skin	18.5 nTPM
Liver	18.3 nTPM
Ovary	17.1 nTPM
Prostate	12.9 nTPM
Placenta	7.3 nTPM
Endometrium	6.2 nTPM
Lung	3.1 nTPM

Fibroblasts	21.0 nTPM
Adipose tissue	37.2 nTPM
Esophagus	36.8 nTPM
Breast	32.1 nTPM
Stomach	28.2 nTPM
Skeletal muscle	23.9 nTPM
Prostate	19.4 nTPM
Placenta	16.9 nTPM
Skin	15.7 nTPM
Heart muscle	9.6 nTPM
Ovary	8.0 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	15.0 nTPM
Rectum	19.2 nTPM
Small intestine	15.1 nTPM
Colon	10.7 nTPM

Macrophages	37.4 nTPM
PBMC	68.2 nTPM
Ovary	56.6 nTPM
Spleen	56.0 nTPM
Kidney	49.1 nTPM
Skeletal muscle	44.2 nTPM
Stomach	43.9 nTPM
Bone marrow	40.0 nTPM
Testis	34.9 nTPM
Breast	32.5 nTPM
Adipose tissue	31.2 nTPM
Esophagus	29.9 nTPM
Prostate	26.3 nTPM
Pancreas	23.0 nTPM
Lung	12.4 nTPM
Endometrium	11.9 nTPM

Paneth cells	21.4 nTPM
Colon	26.4 nTPM
Small intestine	26.3 nTPM
Rectum	11.6 nTPM

Plasma cells	25.2 nTPM
Esophagus	43.0 nTPM
Adipose tissue	34.9 nTPM
Stomach	28.5 nTPM
Bone marrow	9.9 nTPM
Spleen	9.8 nTPM

Respiratory ciliated cells	6.9 nTPM
Bronchus	9.5 nTPM
Lung	4.4 nTPM

Smooth muscle cells	36.8 nTPM
Breast	89.1 nTPM
Skeletal muscle	56.3 nTPM
Esophagus	54.3 nTPM
Prostate	47.8 nTPM
Adipose tissue	39.2 nTPM
Skin	39.0 nTPM
Endometrium	36.8 nTPM
Ovary	16.8 nTPM
Pancreas	10.9 nTPM
Heart muscle	9.7 nTPM
Bronchus	4.8 nTPM

T-cells	38.6 nTPM
Ovary	80.1 nTPM
Lymph node	51.9 nTPM
Kidney	50.0 nTPM
Breast	48.4 nTPM
Liver	48.3 nTPM
Spleen	46.7 nTPM
Colon	44.7 nTPM
Bone marrow	43.4 nTPM
Stomach	41.0 nTPM
PBMC	38.2 nTPM
Adipose tissue	36.9 nTPM
Prostate	33.1 nTPM
Skeletal muscle	26.8 nTPM
Skin	18.5 nTPM
Lung	18.2 nTPM
Endometrium	17.1 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	11.7 nTPM
Skin	11.7 nTPM

Basal prostatic cells	15.6 nTPM
Prostate	15.6 nTPM

Basal respiratory cells	14.2 nTPM
Bronchus	14.2 nTPM

Basal squamous epithelial cells	7.4 nTPM
Esophagus	7.4 nTPM

Undifferentiated cells	10.3 nTPM
Small intestine	15.0 nTPM
Rectum	13.4 nTPM
Colon	2.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC