Single cell type - CTDSP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTDSP1
Gene descriptionⁱ Full gene name according to HGNC.	CTD small phosphatase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (NK-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CTDSP1 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
STK10	Serine/threonine kinase 10	0.6560	63
BIN2	Bridging integrator 2	0.6509	63
CCND3	Cyclin D3	0.6396	51
MYO1F	Myosin IF	0.6214	63
IL12RB1	Interleukin 12 receptor subunit beta 1	0.6180	63
PTGDR	Prostaglandin D2 receptor	0.6170	63
PTGER2	Prostaglandin E receptor 2	0.6164	63
TXK	TXK tyrosine kinase	0.6059	63
CX3CR1	C-X3-C motif chemokine receptor 1	0.6051	63
ABTB1	Ankyrin repeat and BTB domain containing 1	0.6019	19
BTN3A2	Butyrophilin subfamily 3 member A2	0.6001	63
FGFBP2	Fibroblast growth factor binding protein 2	0.5973	63
ITGAL	Integrin subunit alpha L	0.5967	63
TRDC	T cell receptor delta constant	0.5943	63
CD160	CD160 molecule	0.5937	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	65.0 nTPM
Breast	72.8 nTPM
Adipose tissue	57.3 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	40.0 nTPM
Lung	40.0 nTPM

Astrocytes	15.0 nTPM
Brain	15.0 nTPM

B-cells	43.0 nTPM
PBMC	67.1 nTPM
Kidney	57.1 nTPM
Stomach	49.1 nTPM
Bone marrow	48.3 nTPM
Spleen	41.2 nTPM
Lymph node	40.9 nTPM
Adipose tissue	34.5 nTPM
Colon	33.5 nTPM
Breast	29.4 nTPM
Liver	29.2 nTPM

Dendritic cells	70.5 nTPM
Breast	109.7 nTPM
Adipose tissue	85.7 nTPM
PBMC	16.0 nTPM

Endothelial cells	43.4 nTPM
Liver	75.2 nTPM
Skeletal muscle	56.6 nTPM
Ovary	55.6 nTPM
Heart muscle	53.4 nTPM
Breast	52.0 nTPM
Placenta	50.1 nTPM
Testis	48.9 nTPM
Eye	46.9 nTPM
Endometrium	39.9 nTPM
Esophagus	37.6 nTPM
Skin	33.6 nTPM
Prostate	27.1 nTPM
Lung	15.6 nTPM
Pancreas	15.5 nTPM

Fibroblasts	44.7 nTPM
Adipose tissue	79.4 nTPM
Stomach	62.4 nTPM
Breast	60.9 nTPM
Esophagus	51.7 nTPM
Skin	49.7 nTPM
Skeletal muscle	42.0 nTPM
Placenta	39.5 nTPM
Ovary	31.9 nTPM
Heart muscle	28.6 nTPM
Prostate	27.7 nTPM
Lung	17.9 nTPM

Intestinal goblet cells	53.5 nTPM
Rectum	59.2 nTPM
Small intestine	57.1 nTPM
Colon	44.3 nTPM

Macrophages	59.9 nTPM
Skeletal muscle	103.7 nTPM
PBMC	81.8 nTPM
Spleen	72.5 nTPM
Ovary	72.4 nTPM
Pancreas	68.9 nTPM
Kidney	65.8 nTPM
Stomach	61.5 nTPM
Bone marrow	61.2 nTPM
Adipose tissue	60.7 nTPM
Testis	55.8 nTPM
Esophagus	44.1 nTPM
Breast	42.1 nTPM
Lung	39.4 nTPM
Prostate	35.5 nTPM
Endometrium	32.4 nTPM

Paneth cells	43.1 nTPM
Rectum	52.2 nTPM
Colon	39.6 nTPM
Small intestine	37.6 nTPM

Plasma cells	35.7 nTPM
Adipose tissue	61.9 nTPM
Bone marrow	49.4 nTPM
Stomach	39.6 nTPM
Spleen	27.5 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.0 nTPM
Lung	10.2 nTPM
Bronchus	9.8 nTPM

Smooth muscle cells	44.8 nTPM
Breast	84.2 nTPM
Esophagus	65.2 nTPM
Adipose tissue	63.7 nTPM
Skeletal muscle	56.8 nTPM
Skin	44.3 nTPM
Prostate	43.1 nTPM
Ovary	40.3 nTPM
Pancreas	30.9 nTPM
Endometrium	30.5 nTPM
Heart muscle	23.8 nTPM
Bronchus	10.2 nTPM

T-cells	55.1 nTPM
PBMC	85.0 nTPM
Skeletal muscle	78.1 nTPM
Bone marrow	77.8 nTPM
Kidney	74.6 nTPM
Liver	64.7 nTPM
Breast	64.7 nTPM
Ovary	62.3 nTPM
Stomach	61.9 nTPM
Spleen	59.3 nTPM
Adipose tissue	56.9 nTPM
Colon	50.8 nTPM
Lymph node	46.0 nTPM
Skin	40.6 nTPM
Esophagus	39.3 nTPM
Endometrium	37.1 nTPM
Lung	28.8 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	27.3 nTPM
Skin	27.3 nTPM

Basal prostatic cells	29.1 nTPM
Prostate	29.1 nTPM

Basal respiratory cells	24.7 nTPM
Bronchus	24.7 nTPM

Basal squamous epithelial cells	37.5 nTPM
Esophagus	37.5 nTPM

Undifferentiated cells	41.5 nTPM
Rectum	45.1 nTPM
Colon	40.0 nTPM
Small intestine	39.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC