Single cell type - MAP7D1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAP7D1
Gene descriptionⁱ Full gene name according to HGNC.	MAP7 domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAP7D1 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.6659	22
RAB22A	RAB22A, member RAS oncogene family	0.6308	22
ARF6	ADP ribosylation factor 6	0.5819	22
PPP2CA	Protein phosphatase 2 catalytic subunit alpha	0.5761	22
PLEKHN1	Pleckstrin homology domain containing N1	0.5755	22
C3orf52	Chromosome 3 open reading frame 52	0.5687	22
CSNK1A1	Casein kinase 1 alpha 1	0.5573	22
PHLDA3	Pleckstrin homology like domain family A member 3	0.5545	22
YRDC	YrdC N6-threonylcarbamoyltransferase domain containing	0.5531	22
ARL8B	ADP ribosylation factor like GTPase 8B	0.5497	41
STK40	Serine/threonine kinase 40	0.5477	31
PITPNB	Phosphatidylinositol transfer protein beta	0.5356	22
IFFO2	Intermediate filament family orphan 2	0.5324	22
CXCL8	C-X-C motif chemokine ligand 8	0.5323	22
RAB5A	RAB5A, member RAS oncogene family	0.5312	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.6 nTPM
Adipose tissue	42.6 nTPM
Breast	38.6 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	14.4 nTPM
Lung	14.4 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	26.5 nTPM
Lymph node	38.5 nTPM
Spleen	37.1 nTPM
Colon	36.7 nTPM
Breast	34.7 nTPM
Liver	24.3 nTPM
PBMC	22.8 nTPM
Adipose tissue	22.1 nTPM
Stomach	19.5 nTPM
Bone marrow	14.7 nTPM
Kidney	14.3 nTPM

Dendritic cells	58.2 nTPM
Adipose tissue	64.9 nTPM
Breast	58.0 nTPM
PBMC	51.8 nTPM

Endothelial cells	46.7 nTPM
Ovary	78.0 nTPM
Prostate	75.7 nTPM
Testis	63.7 nTPM
Skin	60.5 nTPM
Heart muscle	58.4 nTPM
Skeletal muscle	48.5 nTPM
Placenta	36.4 nTPM
Esophagus	36.2 nTPM
Endometrium	36.1 nTPM
Pancreas	34.7 nTPM
Breast	34.5 nTPM
Eye	33.2 nTPM
Liver	32.1 nTPM
Lung	24.9 nTPM

Fibroblasts	48.0 nTPM
Skin	81.9 nTPM
Prostate	72.0 nTPM
Stomach	66.9 nTPM
Heart muscle	66.6 nTPM
Skeletal muscle	50.9 nTPM
Placenta	37.4 nTPM
Ovary	36.4 nTPM
Adipose tissue	33.9 nTPM
Esophagus	33.2 nTPM
Breast	26.8 nTPM
Lung	22.4 nTPM

Intestinal goblet cells	14.9 nTPM
Small intestine	19.9 nTPM
Colon	15.0 nTPM
Rectum	9.8 nTPM

Macrophages	65.1 nTPM
Prostate	108.9 nTPM
Stomach	99.6 nTPM
Pancreas	99.5 nTPM
Adipose tissue	93.5 nTPM
Bone marrow	80.0 nTPM
Spleen	75.7 nTPM
Kidney	64.3 nTPM
Endometrium	57.1 nTPM
Esophagus	55.1 nTPM
Ovary	53.1 nTPM
Breast	53.1 nTPM
Testis	50.6 nTPM
Skeletal muscle	48.8 nTPM
Lung	37.3 nTPM
PBMC	0.0 nTPM

Paneth cells	29.2 nTPM
Colon	52.6 nTPM
Small intestine	18.8 nTPM
Rectum	16.2 nTPM

Plasma cells	53.2 nTPM
Adipose tissue	69.7 nTPM
Stomach	69.1 nTPM
Esophagus	49.4 nTPM
Spleen	44.8 nTPM
Bone marrow	33.0 nTPM

Respiratory ciliated cells	10.0 nTPM
Bronchus	19.9 nTPM
Lung	0.0 nTPM

Smooth muscle cells	55.8 nTPM
Pancreas	121.0 nTPM
Prostate	72.5 nTPM
Ovary	71.0 nTPM
Heart muscle	61.4 nTPM
Skin	58.6 nTPM
Endometrium	50.7 nTPM
Skeletal muscle	44.5 nTPM
Adipose tissue	37.6 nTPM
Esophagus	37.2 nTPM
Breast	36.4 nTPM
Bronchus	22.7 nTPM

T-cells	59.8 nTPM
Skin	89.8 nTPM
Lymph node	85.0 nTPM
Spleen	71.3 nTPM
Skeletal muscle	69.4 nTPM
Adipose tissue	67.6 nTPM
PBMC	67.0 nTPM
Stomach	63.6 nTPM
Esophagus	58.9 nTPM
Liver	58.6 nTPM
Bone marrow	58.0 nTPM
Prostate	56.8 nTPM
Colon	55.1 nTPM
Breast	54.9 nTPM
Kidney	49.3 nTPM
Ovary	46.7 nTPM
Endometrium	45.7 nTPM
Lung	18.2 nTPM

Basal keratinocytes	143.1 nTPM
Skin	143.1 nTPM

Basal prostatic cells	147.3 nTPM
Prostate	147.3 nTPM

Basal respiratory cells	18.4 nTPM
Bronchus	18.4 nTPM

Basal squamous epithelial cells	47.8 nTPM
Esophagus	47.8 nTPM

Undifferentiated cells	19.5 nTPM
Colon	23.7 nTPM
Small intestine	21.2 nTPM
Rectum	13.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC