Single cell type - RPAP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPAP2
Gene descriptionⁱ Full gene name according to HGNC.	RNA polymerase II associated protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RPAP2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ANKRD42	Ankyrin repeat domain 42	0.5964	49
AAK1	AP2 associated kinase 1	0.5555	9
MAP3K12	Mitogen-activated protein kinase kinase kinase 12	0.5392	46
GPATCH2	G-patch domain containing 2	0.5339	9
GOLGA8A	Golgin A8 family member A	0.5164	52
ZNF605	Zinc finger protein 605	0.5154	52
POLR3A	RNA polymerase III subunit A	0.5104	9
GON4L	Gon-4 like	0.4918	46
GLMN	Glomulin, FKBP associated protein	0.4877	46
ZRANB2	Zinc finger RANBP2-type containing 2	0.4863	52
SART3	Spliceosome associated factor 3, U4/U6 recycling protein	0.4862	23
KIAA0586	KIAA0586	0.4861	23
PNPT1	Polyribonucleotide nucleotidyltransferase 1	0.4825	11
METTL16	Methyltransferase like 16	0.4764	52
ZNF527	Zinc finger protein 527	0.4762	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.1 nTPM
Breast	28.4 nTPM
Adipose tissue	17.7 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	78.5 nTPM
Lung	78.5 nTPM

Astrocytes	66.9 nTPM
Brain	66.9 nTPM

B-cells	20.1 nTPM
PBMC	35.7 nTPM
Stomach	27.7 nTPM
Breast	22.8 nTPM
Lymph node	22.1 nTPM
Spleen	21.8 nTPM
Adipose tissue	21.6 nTPM
Bone marrow	21.3 nTPM
Liver	11.0 nTPM
Kidney	9.5 nTPM
Colon	8.0 nTPM

Dendritic cells	31.5 nTPM
Adipose tissue	51.7 nTPM
Breast	27.0 nTPM
PBMC	16.0 nTPM

Endothelial cells	23.4 nTPM
Heart muscle	50.6 nTPM
Lung	43.7 nTPM
Endometrium	31.2 nTPM
Skeletal muscle	28.9 nTPM
Ovary	26.1 nTPM
Eye	25.1 nTPM
Esophagus	22.2 nTPM
Testis	18.7 nTPM
Liver	17.4 nTPM
Placenta	17.0 nTPM
Breast	15.4 nTPM
Pancreas	11.6 nTPM
Skin	9.7 nTPM
Prostate	9.6 nTPM

Fibroblasts	24.8 nTPM
Lung	67.0 nTPM
Skeletal muscle	30.8 nTPM
Ovary	30.1 nTPM
Breast	26.9 nTPM
Stomach	25.3 nTPM
Adipose tissue	19.1 nTPM
Heart muscle	18.0 nTPM
Esophagus	17.6 nTPM
Placenta	15.6 nTPM
Prostate	13.9 nTPM
Skin	8.9 nTPM

Intestinal goblet cells	13.3 nTPM
Small intestine	14.9 nTPM
Rectum	12.8 nTPM
Colon	12.1 nTPM

Macrophages	15.6 nTPM
Lung	67.9 nTPM
Stomach	23.5 nTPM
Breast	19.9 nTPM
Endometrium	18.5 nTPM
Ovary	18.2 nTPM
Skeletal muscle	14.7 nTPM
Testis	12.2 nTPM
Adipose tissue	10.6 nTPM
Spleen	10.4 nTPM
Kidney	9.9 nTPM
Prostate	8.1 nTPM
Esophagus	7.9 nTPM
Bone marrow	7.5 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	13.6 nTPM
Small intestine	22.5 nTPM
Rectum	11.7 nTPM
Colon	6.5 nTPM

Plasma cells	28.5 nTPM
Adipose tissue	34.9 nTPM
Stomach	33.1 nTPM
Bone marrow	26.4 nTPM
Esophagus	24.6 nTPM
Spleen	23.7 nTPM

Respiratory ciliated cells	45.0 nTPM
Lung	81.6 nTPM
Bronchus	8.4 nTPM

Smooth muscle cells	20.3 nTPM
Endometrium	36.9 nTPM
Ovary	31.7 nTPM
Skeletal muscle	30.5 nTPM
Heart muscle	28.5 nTPM
Adipose tissue	23.0 nTPM
Breast	20.8 nTPM
Pancreas	16.5 nTPM
Prostate	13.4 nTPM
Skin	10.1 nTPM
Esophagus	9.3 nTPM
Bronchus	2.8 nTPM

T-cells	35.8 nTPM
Lung	91.1 nTPM
PBMC	59.5 nTPM
Skeletal muscle	54.5 nTPM
Stomach	44.6 nTPM
Endometrium	36.9 nTPM
Adipose tissue	35.4 nTPM
Bone marrow	35.1 nTPM
Ovary	31.1 nTPM
Breast	31.0 nTPM
Lymph node	30.9 nTPM
Spleen	30.6 nTPM
Colon	29.0 nTPM
Liver	27.6 nTPM
Kidney	26.0 nTPM
Prostate	23.6 nTPM
Esophagus	13.1 nTPM
Skin	9.2 nTPM

Basal prostatic cells	16.7 nTPM
Prostate	16.7 nTPM

Basal respiratory cells	15.7 nTPM
Bronchus	15.7 nTPM

Basal squamous epithelial cells	23.9 nTPM
Esophagus	23.9 nTPM

Cholangiocytes	10.0 nTPM
Liver	10.0 nTPM

Undifferentiated cells	12.1 nTPM
Small intestine	14.3 nTPM
Rectum	13.7 nTPM
Colon	8.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC