Single cell type - MPHOSPH10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPHOSPH10
Gene descriptionⁱ Full gene name according to HGNC.	M-phase phosphoprotein 10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPHOSPH10 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.98
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DNTTIP2	Deoxynucleotidyltransferase terminal interacting protein 2	0.6191	10
PNN	Pinin, desmosome associated protein	0.6077	52
DHX9	DExH-box helicase 9	0.5907	44
THRAP3	Thyroid hormone receptor associated protein 3	0.5744	10
PAK1IP1	PAK1 interacting protein 1	0.5718	39
KRR1	KRR1 small subunit processome component homolog	0.5691	39
HNRNPM	Heterogeneous nuclear ribonucleoprotein M	0.5495	10
LTV1	LTV1 ribosome biogenesis factor	0.5471	39
AKAP8	A-kinase anchoring protein 8	0.5453	44
KIN	Kin17 DNA and RNA binding protein	0.5452	10
MAK16	MAK16 homolog	0.5452	10
SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein	0.5429	10
BAZ1B	Bromodomain adjacent to zinc finger domain 1B	0.5391	10
CCDC47	Coiled-coil domain containing 47	0.5307	10
YTHDC1	YTH domain containing 1	0.5296	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.6 nTPM
Breast	46.8 nTPM
Adipose tissue	30.4 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	55.5 nTPM
Lung	55.5 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	36.8 nTPM
Breast	46.8 nTPM
PBMC	45.7 nTPM
Adipose tissue	42.2 nTPM
Colon	39.9 nTPM
Liver	39.1 nTPM
Kidney	38.1 nTPM
Stomach	32.2 nTPM
Bone marrow	31.1 nTPM
Lymph node	27.6 nTPM
Spleen	25.3 nTPM

Dendritic cells	47.7 nTPM
Adipose tissue	62.0 nTPM
Breast	49.2 nTPM
PBMC	31.8 nTPM

Endothelial cells	40.4 nTPM
Lung	71.7 nTPM
Pancreas	65.6 nTPM
Skeletal muscle	51.5 nTPM
Prostate	47.2 nTPM
Heart muscle	45.5 nTPM
Ovary	41.8 nTPM
Endometrium	40.4 nTPM
Testis	32.3 nTPM
Eye	31.6 nTPM
Placenta	30.1 nTPM
Liver	27.5 nTPM
Esophagus	27.3 nTPM
Breast	26.8 nTPM
Skin	25.8 nTPM

Fibroblasts	43.2 nTPM
Lung	99.4 nTPM
Skeletal muscle	53.7 nTPM
Heart muscle	49.6 nTPM
Placenta	42.3 nTPM
Prostate	42.0 nTPM
Adipose tissue	41.4 nTPM
Breast	40.5 nTPM
Ovary	28.9 nTPM
Esophagus	26.9 nTPM
Skin	26.8 nTPM
Stomach	23.7 nTPM

Intestinal goblet cells	21.6 nTPM
Colon	29.3 nTPM
Rectum	20.7 nTPM
Small intestine	15.0 nTPM

Macrophages	19.0 nTPM
Lung	41.1 nTPM
Breast	35.6 nTPM
Testis	29.1 nTPM
Endometrium	28.4 nTPM
Pancreas	28.0 nTPM
Ovary	22.6 nTPM
Adipose tissue	19.8 nTPM
Skeletal muscle	19.5 nTPM
Kidney	15.8 nTPM
Bone marrow	15.0 nTPM
Prostate	13.8 nTPM
Esophagus	12.6 nTPM
Spleen	4.2 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	15.0 nTPM
Rectum	23.9 nTPM
Small intestine	11.3 nTPM
Colon	9.9 nTPM

Plasma cells	25.6 nTPM
Adipose tissue	33.6 nTPM
Bone marrow	31.3 nTPM
Stomach	30.0 nTPM
Spleen	26.7 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	29.2 nTPM
Lung	42.3 nTPM
Bronchus	16.1 nTPM

Smooth muscle cells	49.1 nTPM
Bronchus	79.1 nTPM
Heart muscle	76.9 nTPM
Pancreas	69.4 nTPM
Ovary	52.2 nTPM
Breast	47.3 nTPM
Endometrium	44.6 nTPM
Skeletal muscle	41.9 nTPM
Prostate	39.0 nTPM
Adipose tissue	37.3 nTPM
Esophagus	26.4 nTPM
Skin	26.2 nTPM

T-cells	39.9 nTPM
Lung	66.8 nTPM
PBMC	60.8 nTPM
Adipose tissue	58.2 nTPM
Colon	55.6 nTPM
Breast	49.1 nTPM
Ovary	48.9 nTPM
Endometrium	47.4 nTPM
Kidney	42.4 nTPM
Skeletal muscle	41.5 nTPM
Prostate	37.9 nTPM
Liver	32.7 nTPM
Stomach	29.6 nTPM
Lymph node	26.9 nTPM
Skin	25.7 nTPM
Bone marrow	23.0 nTPM
Spleen	18.5 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	33.4 nTPM
Skin	33.4 nTPM

Basal prostatic cells	42.7 nTPM
Prostate	42.7 nTPM

Basal respiratory cells	37.8 nTPM
Bronchus	37.8 nTPM

Basal squamous epithelial cells	30.7 nTPM
Esophagus	30.7 nTPM

Undifferentiated cells	28.2 nTPM
Colon	36.3 nTPM
Small intestine	24.9 nTPM
Rectum	23.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC