Single cell type - THRAP3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	THRAP3
Gene descriptionⁱ Full gene name according to HGNC.	Thyroid hormone receptor associated protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

THRAP3 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.99
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MPHOSPH10	M-phase phosphoprotein 10	0.5744	10
HNRNPR	Heterogeneous nuclear ribonucleoprotein R	0.5668	10
ZC3H13	Zinc finger CCCH-type containing 13	0.5667	10
PHAX	Phosphorylated adaptor for RNA export	0.5460	10
KRR1	KRR1 small subunit processome component homolog	0.5344	39
XRCC5	X-ray repair cross complementing 5	0.5322	10
U2SURP	U2 snRNP associated SURP domain containing	0.5137	10
DDX6	DEAD-box helicase 6	0.4951	24
CRNKL1	Crooked neck pre-mRNA splicing factor 1	0.4939	52
TPR	Translocated promoter region, nuclear basket protein	0.4914	13
PPIG	Peptidylprolyl isomerase G	0.4862	10
NKAP	NFKB activating protein	0.4848	38
RPL7L1	Ribosomal protein L7 like 1	0.4773	52
SMC1A	Structural maintenance of chromosomes 1A	0.4729	10
MFAP1	Microfibril associated protein 1	0.4712	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	101.0 nTPM
Adipose tissue	103.7 nTPM
Breast	98.3 nTPM

Alveolar cells type 1	115.4 nTPM
Lung	115.4 nTPM

Alveolar cells type 2	101.7 nTPM
Lung	101.7 nTPM

Astrocytes	32.3 nTPM
Brain	32.3 nTPM

B-cells	136.1 nTPM
PBMC	202.7 nTPM
Adipose tissue	158.9 nTPM
Colon	156.6 nTPM
Bone marrow	138.9 nTPM
Lymph node	136.4 nTPM
Stomach	126.7 nTPM
Liver	126.5 nTPM
Kidney	119.0 nTPM
Spleen	113.5 nTPM
Breast	81.7 nTPM

Dendritic cells	151.9 nTPM
Adipose tissue	203.5 nTPM
PBMC	143.4 nTPM
Breast	108.6 nTPM

Endothelial cells	96.2 nTPM
Pancreas	123.5 nTPM
Ovary	109.2 nTPM
Eye	107.6 nTPM
Endometrium	105.6 nTPM
Heart muscle	104.4 nTPM
Lung	102.9 nTPM
Placenta	97.8 nTPM
Skeletal muscle	97.2 nTPM
Liver	94.5 nTPM
Breast	90.9 nTPM
Prostate	89.9 nTPM
Testis	84.2 nTPM
Esophagus	75.4 nTPM
Skin	64.0 nTPM

Erythroid cells	114.9 nTPM
Bone marrow	122.7 nTPM
Liver	107.0 nTPM

Fibroblasts	98.3 nTPM
Heart muscle	126.4 nTPM
Adipose tissue	114.0 nTPM
Ovary	105.4 nTPM
Esophagus	100.4 nTPM
Stomach	99.5 nTPM
Placenta	98.2 nTPM
Lung	93.8 nTPM
Breast	93.8 nTPM
Prostate	92.8 nTPM
Skeletal muscle	86.3 nTPM
Skin	70.7 nTPM

Intestinal goblet cells	70.1 nTPM
Colon	90.8 nTPM
Rectum	67.4 nTPM
Small intestine	51.9 nTPM

Macrophages	89.9 nTPM
Adipose tissue	130.1 nTPM
Bone marrow	114.9 nTPM
Lung	112.1 nTPM
Kidney	104.3 nTPM
Ovary	103.5 nTPM
Endometrium	103.2 nTPM
Spleen	90.2 nTPM
Testis	85.9 nTPM
Skeletal muscle	84.8 nTPM
Breast	84.8 nTPM
Prostate	83.7 nTPM
Esophagus	78.7 nTPM
Pancreas	74.0 nTPM
Stomach	70.3 nTPM
PBMC	27.3 nTPM

Paneth cells	61.9 nTPM
Rectum	76.7 nTPM
Small intestine	56.3 nTPM
Colon	52.6 nTPM

Plasma cells	119.7 nTPM
Bone marrow	158.2 nTPM
Spleen	131.7 nTPM
Stomach	122.1 nTPM
Adipose tissue	106.5 nTPM
Esophagus	80.1 nTPM

Respiratory ciliated cells	87.6 nTPM
Lung	107.8 nTPM
Bronchus	67.3 nTPM

Smooth muscle cells	116.5 nTPM
Bronchus	166.7 nTPM
Pancreas	147.5 nTPM
Heart muscle	142.9 nTPM
Ovary	124.0 nTPM
Skeletal muscle	119.5 nTPM
Endometrium	110.6 nTPM
Adipose tissue	106.6 nTPM
Breast	104.5 nTPM
Esophagus	99.2 nTPM
Prostate	92.6 nTPM
Skin	67.3 nTPM

Basal keratinocytes	56.7 nTPM
Skin	56.7 nTPM

Basal respiratory cells	126.9 nTPM
Bronchus	126.9 nTPM

Basal squamous epithelial cells	78.0 nTPM
Esophagus	78.0 nTPM

Cholangiocytes	75.8 nTPM
Liver	75.8 nTPM

T-cells	129.0 nTPM
Adipose tissue	192.2 nTPM
PBMC	166.3 nTPM
Kidney	143.1 nTPM
Colon	143.0 nTPM
Ovary	135.6 nTPM
Bone marrow	133.2 nTPM
Skeletal muscle	129.9 nTPM
Stomach	125.5 nTPM
Lung	123.0 nTPM
Spleen	122.6 nTPM
Liver	122.1 nTPM
Lymph node	116.2 nTPM
Prostate	113.7 nTPM
Endometrium	112.4 nTPM
Esophagus	111.4 nTPM
Skin	104.5 nTPM
Breast	98.4 nTPM

Undifferentiated cells	87.1 nTPM
Colon	100.5 nTPM
Small intestine	83.9 nTPM
Rectum	76.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC