Single cell type - ZNF384 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF384
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 384
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNF384 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NUMA1	Nuclear mitotic apparatus protein 1	0.6004	44
MCM3AP	Minichromosome maintenance complex component 3 associated protein	0.5354	59
GABPA	GA binding protein transcription factor subunit alpha	0.5324	59
HNRNPL	Heterogeneous nuclear ribonucleoprotein L	0.5245	59
MTA2	Metastasis associated 1 family member 2	0.4989	59
PRRC2A	Proline rich coiled-coil 2A	0.4979	59
ZNF768	Zinc finger protein 768	0.4936	53
POM121C	POM121 transmembrane nucleoporin C	0.4936	59
CES3	Carboxylesterase 3	0.4906	53
TRRAP	Transformation/transcription domain associated protein	0.4876	44
RRN3	RRN3 homolog, RNA polymerase I transcription factor	0.4780	59
PPP1R10	Protein phosphatase 1 regulatory subunit 10	0.4751	7
NHEJ1	Non-homologous end joining factor 1	0.4750	59
TP53	Tumor protein p53	0.4702	32
POM121	POM121 transmembrane nucleoporin	0.4686	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.2 nTPM
Adipose tissue	23.8 nTPM
Breast	14.7 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	8.7 nTPM
Lung	8.7 nTPM

Astrocytes	17.3 nTPM
Brain	17.3 nTPM

B-cells	12.5 nTPM
Lymph node	25.6 nTPM
Bone marrow	19.6 nTPM
Stomach	15.9 nTPM
Spleen	14.2 nTPM
Breast	12.1 nTPM
PBMC	11.5 nTPM
Adipose tissue	11.1 nTPM
Colon	8.0 nTPM
Liver	7.5 nTPM
Kidney	0.0 nTPM

Dendritic cells	17.9 nTPM
Adipose tissue	20.7 nTPM
Breast	17.1 nTPM
PBMC	16.0 nTPM

Endothelial cells	10.7 nTPM
Endometrium	22.1 nTPM
Esophagus	22.1 nTPM
Breast	14.9 nTPM
Skeletal muscle	14.7 nTPM
Ovary	13.8 nTPM
Testis	12.2 nTPM
Liver	11.9 nTPM
Eye	7.3 nTPM
Skin	7.3 nTPM
Prostate	7.0 nTPM
Placenta	6.2 nTPM
Pancreas	3.9 nTPM
Heart muscle	3.1 nTPM
Lung	3.1 nTPM

Fibroblasts	8.2 nTPM
Esophagus	12.8 nTPM
Adipose tissue	12.2 nTPM
Breast	11.0 nTPM
Skeletal muscle	10.4 nTPM
Ovary	10.0 nTPM
Skin	7.5 nTPM
Stomach	7.4 nTPM
Lung	6.7 nTPM
Placenta	6.1 nTPM
Prostate	4.0 nTPM
Heart muscle	1.7 nTPM

Intestinal goblet cells	11.8 nTPM
Rectum	16.4 nTPM
Small intestine	11.7 nTPM
Colon	7.2 nTPM

Macrophages	8.6 nTPM
Adipose tissue	13.7 nTPM
Breast	12.2 nTPM
Skeletal muscle	11.9 nTPM
Spleen	11.4 nTPM
Lung	11.3 nTPM
Endometrium	10.3 nTPM
Esophagus	9.4 nTPM
Testis	8.8 nTPM
Stomach	8.8 nTPM
Bone marrow	8.7 nTPM
Ovary	8.4 nTPM
Prostate	8.1 nTPM
Kidney	3.8 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	14.4 nTPM
Colon	16.5 nTPM
Rectum	15.5 nTPM
Small intestine	11.3 nTPM

Plasma cells	11.4 nTPM
Adipose tissue	23.9 nTPM
Spleen	13.6 nTPM
Stomach	12.8 nTPM
Bone marrow	6.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.6 nTPM
Bronchus	7.0 nTPM
Lung	4.4 nTPM

Smooth muscle cells	9.3 nTPM
Endometrium	16.5 nTPM
Adipose tissue	15.1 nTPM
Ovary	14.6 nTPM
Esophagus	12.4 nTPM
Breast	12.2 nTPM
Skeletal muscle	10.6 nTPM
Skin	9.1 nTPM
Bronchus	4.7 nTPM
Prostate	3.7 nTPM
Pancreas	3.2 nTPM
Heart muscle	0.7 nTPM

T-cells	13.2 nTPM
Lymph node	22.0 nTPM
Esophagus	19.7 nTPM
Bone marrow	17.4 nTPM
Adipose tissue	16.7 nTPM
Skeletal muscle	16.2 nTPM
Breast	16.0 nTPM
Endometrium	15.6 nTPM
Colon	15.2 nTPM
Spleen	14.0 nTPM
Lung	13.6 nTPM
Ovary	13.4 nTPM
Stomach	12.9 nTPM
Liver	10.9 nTPM
Skin	7.8 nTPM
PBMC	7.7 nTPM
Kidney	4.7 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	7.9 nTPM
Skin	7.9 nTPM

Basal prostatic cells	2.6 nTPM
Prostate	2.6 nTPM

Basal squamous epithelial cells	12.0 nTPM
Esophagus	12.0 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Undifferentiated cells	13.4 nTPM
Rectum	15.4 nTPM
Colon	14.0 nTPM
Small intestine	10.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC