Single cell type - GNAI1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNAI1
Gene descriptionⁱ Full gene name according to HGNC.	G protein subunit alpha i1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Basal keratinocytes, Suprabasal keratinocytes, Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Basal keratinocytes, Suprabasal keratinocytes, Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GNAI1 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRRG1	Proline rich and Gla domain 1	0.5830	42
NKAIN1	Sodium/potassium transporting ATPase interacting 1	0.5770	42
PTBP2	Polypyrimidine tract binding protein 2	0.5636	42
HS3ST5	Heparan sulfate-glucosamine 3-sulfotransferase 5	0.5390	42
HAPLN2	Hyaluronan and proteoglycan link protein 2	0.5279	42
JAM3	Junctional adhesion molecule 3	0.5172	42
PLET1	Placenta expressed transcript 1	0.5062	42
RILPL1	Rab interacting lysosomal protein like 1	0.5052	42
GLDN	Gliomedin	0.5051	42
PRUNE2	Prune homolog 2 with BCH domain	0.5023	42
DIP2B	Disco interacting protein 2 homolog B	0.4985	42
FAM13C	Family with sequence similarity 13 member C	0.4964	42
PEX5L	Peroxisomal biogenesis factor 5 like	0.4915	42
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.4892	42
MTMR2	Myotubularin related protein 2	0.4886	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	121.1 nTPM
Breast	148.8 nTPM
Adipose tissue	93.5 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	13.8 nTPM
Lung	13.8 nTPM

Astrocytes	11.4 nTPM
Brain	11.4 nTPM

B-cells	0.9 nTPM
Kidney	4.8 nTPM
Colon	1.6 nTPM
PBMC	1.4 nTPM
Bone marrow	0.8 nTPM
Spleen	0.3 nTPM
Lymph node	0.1 nTPM
Liver	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	1.3 nTPM
Adipose tissue	3.2 nTPM
Breast	0.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	31.5 nTPM
Ovary	62.6 nTPM
Breast	60.2 nTPM
Skeletal muscle	48.7 nTPM
Pancreas	42.5 nTPM
Heart muscle	38.6 nTPM
Skin	36.7 nTPM
Liver	28.4 nTPM
Testis	26.1 nTPM
Endometrium	25.3 nTPM
Eye	18.6 nTPM
Placenta	17.6 nTPM
Prostate	15.3 nTPM
Esophagus	14.5 nTPM
Lung	6.2 nTPM

Fibroblasts	35.9 nTPM
Placenta	130.9 nTPM
Skin	64.5 nTPM
Stomach	34.1 nTPM
Adipose tissue	28.9 nTPM
Prostate	28.0 nTPM
Esophagus	26.1 nTPM
Lung	24.6 nTPM
Breast	18.3 nTPM
Skeletal muscle	17.7 nTPM
Ovary	10.8 nTPM
Heart muscle	10.6 nTPM

Intestinal goblet cells	7.8 nTPM
Small intestine	9.2 nTPM
Rectum	8.5 nTPM
Colon	5.8 nTPM

Macrophages	3.9 nTPM
Breast	12.7 nTPM
Endometrium	8.2 nTPM
Prostate	6.9 nTPM
Testis	6.9 nTPM
Esophagus	6.3 nTPM
Ovary	5.0 nTPM
Lung	4.4 nTPM
Skeletal muscle	3.6 nTPM
Adipose tissue	1.7 nTPM
Kidney	1.5 nTPM
Bone marrow	1.2 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	6.3 nTPM
Small intestine	11.3 nTPM
Rectum	7.7 nTPM
Colon	0.0 nTPM

Plasma cells	1.2 nTPM
Esophagus	6.1 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	36.8 nTPM
Lung	39.4 nTPM
Bronchus	34.2 nTPM

Smooth muscle cells	70.8 nTPM
Ovary	193.0 nTPM
Skeletal muscle	96.2 nTPM
Adipose tissue	79.2 nTPM
Skin	76.3 nTPM
Endometrium	74.1 nTPM
Heart muscle	71.9 nTPM
Esophagus	58.9 nTPM
Breast	50.6 nTPM
Bronchus	31.0 nTPM
Pancreas	27.7 nTPM
Prostate	19.6 nTPM

T-cells	2.9 nTPM
Skin	24.4 nTPM
Endometrium	7.1 nTPM
Lung	6.1 nTPM
PBMC	2.8 nTPM
Skeletal muscle	1.5 nTPM
Spleen	1.5 nTPM
Breast	1.5 nTPM
Lymph node	1.3 nTPM
Liver	1.1 nTPM
Colon	1.0 nTPM
Adipose tissue	0.6 nTPM
Bone marrow	0.4 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cytotrophoblasts	83.6 nTPM
Placenta	83.6 nTPM

Distal enterocytes	11.1 nTPM
Rectum	13.4 nTPM
Colon	8.8 nTPM

Undifferentiated cells	10.7 nTPM
Colon	12.6 nTPM
Small intestine	10.3 nTPM
Rectum	9.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC