Single cell type - RCBTB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RCBTB2
Gene descriptionⁱ Full gene name according to HGNC.	RCC1 and BTB domain containing protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (MOLT-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RCBTB2 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MYO1F	Myosin IF	0.6912	63
CX3CR1	C-X3-C motif chemokine receptor 1	0.6645	63
FES	FES proto-oncogene, tyrosine kinase	0.6211	10
ABI3	ABI family member 3	0.6146	63
SNX20	Sorting nexin 20	0.6143	63
GNGT2	G protein subunit gamma transducin 2	0.6104	63
ITGAM	Integrin subunit alpha M	0.6063	19
ITGB2	Integrin subunit beta 2	0.6036	63
CORO1A	Coronin 1A	0.6023	63
ARHGAP30	Rho GTPase activating protein 30	0.6014	63
GIMAP4	GTPase, IMAP family member 4	0.5951	63
GIMAP2	GTPase, IMAP family member 2	0.5950	63
PADI6	Peptidyl arginine deiminase 6	0.5924	63
APBB1IP	Amyloid beta precursor protein binding family B member 1 interacting protein	0.5920	63
AOAH	Acyloxyacyl hydrolase	0.5836	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.1 nTPM
Breast	26.5 nTPM
Adipose tissue	19.8 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	3.3 nTPM
Lung	3.3 nTPM

Astrocytes	9.1 nTPM
Brain	9.1 nTPM

B-cells	5.5 nTPM
Liver	27.2 nTPM
Lymph node	6.4 nTPM
Breast	5.3 nTPM
Spleen	4.2 nTPM
PBMC	2.8 nTPM
Stomach	2.7 nTPM
Adipose tissue	2.5 nTPM
Bone marrow	2.5 nTPM
Colon	1.6 nTPM
Kidney	0.0 nTPM

Dendritic cells	20.7 nTPM
Breast	40.5 nTPM
Adipose tissue	21.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	19.7 nTPM
Placenta	49.5 nTPM
Heart muscle	32.1 nTPM
Eye	31.6 nTPM
Breast	24.3 nTPM
Liver	21.1 nTPM
Esophagus	18.6 nTPM
Ovary	18.4 nTPM
Endometrium	18.2 nTPM
Skin	17.9 nTPM
Testis	16.9 nTPM
Skeletal muscle	13.2 nTPM
Prostate	8.3 nTPM
Lung	6.2 nTPM
Pancreas	0.0 nTPM

Fibroblasts	11.6 nTPM
Ovary	16.6 nTPM
Heart muscle	15.7 nTPM
Breast	15.3 nTPM
Skeletal muscle	13.1 nTPM
Skin	12.9 nTPM
Esophagus	12.2 nTPM
Stomach	11.9 nTPM
Placenta	10.2 nTPM
Adipose tissue	10.0 nTPM
Prostate	6.7 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	2.2 nTPM
Small intestine	3.2 nTPM
Colon	2.2 nTPM
Rectum	1.4 nTPM

Macrophages	30.6 nTPM
Bone marrow	60.0 nTPM
Spleen	47.7 nTPM
Kidney	47.6 nTPM
Testis	41.2 nTPM
Ovary	33.4 nTPM
Adipose tissue	32.1 nTPM
Skeletal muscle	31.0 nTPM
Prostate	29.8 nTPM
Breast	27.7 nTPM
Stomach	26.4 nTPM
Endometrium	24.9 nTPM
Lung	23.6 nTPM
Esophagus	23.6 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	1.6 nTPM
Small intestine	3.7 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM

Plasma cells	17.4 nTPM
Bone marrow	34.6 nTPM
Spleen	29.6 nTPM
Adipose tissue	12.2 nTPM
Esophagus	6.1 nTPM
Stomach	4.6 nTPM

Respiratory ciliated cells	6.9 nTPM
Bronchus	11.0 nTPM
Lung	2.9 nTPM

Smooth muscle cells	14.1 nTPM
Bronchus	58.1 nTPM
Heart muscle	19.2 nTPM
Adipose tissue	11.4 nTPM
Skin	10.9 nTPM
Breast	10.6 nTPM
Ovary	9.4 nTPM
Esophagus	9.3 nTPM
Endometrium	8.9 nTPM
Skeletal muscle	8.9 nTPM
Prostate	5.3 nTPM
Pancreas	3.6 nTPM

T-cells	24.0 nTPM
Skin	126.2 nTPM
Liver	43.9 nTPM
Kidney	31.5 nTPM
Bone marrow	31.4 nTPM
Spleen	26.2 nTPM
PBMC	24.4 nTPM
Lymph node	20.6 nTPM
Lung	18.2 nTPM
Skeletal muscle	15.9 nTPM
Ovary	15.6 nTPM
Adipose tissue	12.8 nTPM
Colon	11.4 nTPM
Breast	9.7 nTPM
Stomach	8.3 nTPM
Esophagus	6.6 nTPM
Endometrium	5.0 nTPM
Prostate	0.0 nTPM

Basal respiratory cells	9.5 nTPM
Bronchus	9.5 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Distal tubular cells	7.9 nTPM
Kidney	7.9 nTPM

Undifferentiated cells	2.4 nTPM
Small intestine	3.5 nTPM
Rectum	2.2 nTPM
Colon	1.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC