Single cell type - SLC35B1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC35B1
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 35 member B1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC35B1 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AUP1	AUP1 lipid droplet regulating VLDL assembly factor	0.7731	55
MANF	Mesencephalic astrocyte derived neurotrophic factor	0.6979	55
DERL1	Derlin 1	0.6745	55
YIF1A	Yip1 interacting factor homolog A, membrane trafficking protein	0.6647	10
LRRC59	Leucine rich repeat containing 59	0.6516	55
DNAJB11	DnaJ heat shock protein family (Hsp40) member B11	0.6240	55
DNAJC3	DnaJ heat shock protein family (Hsp40) member C3	0.6138	55
PSME2	Proteasome activator subunit 2	0.6111	10
TMEM208	Transmembrane protein 208	0.6064	55
SURF4	Surfeit 4	0.5898	55
SDF2L1	Stromal cell derived factor 2 like 1	0.5869	55
SEC13	SEC13 homolog, nuclear pore and COPII coat complex component	0.5594	55
MED8	Mediator complex subunit 8	0.5532	10
RHEB	Ras homolog, mTORC1 binding	0.5281	10
MTDH	Metadherin	0.5243	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.1 nTPM
Breast	37.8 nTPM
Adipose tissue	26.4 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	29.7 nTPM
Lung	29.7 nTPM

Astrocytes	10.7 nTPM
Brain	10.7 nTPM

B-cells	37.1 nTPM
Liver	174.5 nTPM
Breast	78.8 nTPM
Colon	20.8 nTPM
Stomach	17.7 nTPM
Lymph node	16.0 nTPM
Spleen	16.0 nTPM
PBMC	14.3 nTPM
Adipose tissue	14.1 nTPM
Bone marrow	13.9 nTPM
Kidney	4.8 nTPM

Dendritic cells	47.4 nTPM
Adipose tissue	52.2 nTPM
Breast	50.3 nTPM
PBMC	39.8 nTPM

Endothelial cells	39.2 nTPM
Pancreas	77.2 nTPM
Ovary	54.1 nTPM
Prostate	51.8 nTPM
Placenta	51.7 nTPM
Breast	39.3 nTPM
Lung	37.4 nTPM
Skin	37.0 nTPM
Testis	31.7 nTPM
Endometrium	29.2 nTPM
Esophagus	29.0 nTPM
Skeletal muscle	28.5 nTPM
Liver	28.4 nTPM
Eye	28.3 nTPM
Heart muscle	25.6 nTPM

Fibroblasts	28.6 nTPM
Placenta	58.9 nTPM
Prostate	47.5 nTPM
Breast	35.5 nTPM
Ovary	28.6 nTPM
Skin	25.8 nTPM
Lung	25.7 nTPM
Adipose tissue	22.9 nTPM
Skeletal muscle	21.0 nTPM
Esophagus	20.3 nTPM
Heart muscle	19.3 nTPM
Stomach	8.9 nTPM

Intestinal goblet cells	56.2 nTPM
Colon	97.9 nTPM
Small intestine	41.3 nTPM
Rectum	29.3 nTPM

Macrophages	34.0 nTPM
Pancreas	84.2 nTPM
Prostate	72.3 nTPM
Kidney	37.8 nTPM
Testis	37.8 nTPM
Ovary	37.7 nTPM
Breast	35.9 nTPM
Lung	33.9 nTPM
Endometrium	31.4 nTPM
Adipose tissue	28.7 nTPM
Bone marrow	27.5 nTPM
Skeletal muscle	26.8 nTPM
Spleen	17.6 nTPM
PBMC	13.6 nTPM
Esophagus	12.6 nTPM
Stomach	11.7 nTPM

Paneth cells	33.2 nTPM
Colon	42.8 nTPM
Rectum	30.5 nTPM
Small intestine	26.3 nTPM

Plasma cells	103.7 nTPM
Spleen	157.4 nTPM
Bone marrow	128.6 nTPM
Stomach	116.6 nTPM
Esophagus	74.0 nTPM
Adipose tissue	41.9 nTPM

Respiratory ciliated cells	33.9 nTPM
Bronchus	34.2 nTPM
Lung	33.5 nTPM

Smooth muscle cells	47.9 nTPM
Bronchus	221.1 nTPM
Pancreas	104.0 nTPM
Ovary	40.0 nTPM
Breast	26.5 nTPM
Esophagus	26.4 nTPM
Endometrium	20.3 nTPM
Skeletal muscle	20.3 nTPM
Skin	19.9 nTPM
Prostate	17.2 nTPM
Adipose tissue	15.8 nTPM
Heart muscle	14.9 nTPM

T-cells	31.1 nTPM
Skin	47.8 nTPM
Lung	44.0 nTPM
Breast	41.2 nTPM
Colon	39.9 nTPM
Stomach	39.8 nTPM
Liver	36.6 nTPM
Prostate	33.1 nTPM
Adipose tissue	30.7 nTPM
Skeletal muscle	30.6 nTPM
Kidney	28.7 nTPM
Ovary	26.7 nTPM
Endometrium	24.4 nTPM
PBMC	24.1 nTPM
Spleen	21.9 nTPM
Bone marrow	21.3 nTPM
Esophagus	19.7 nTPM
Lymph node	18.3 nTPM

Basal keratinocytes	22.3 nTPM
Skin	22.3 nTPM

Basal respiratory cells	56.4 nTPM
Bronchus	56.4 nTPM

Basal squamous epithelial cells	22.8 nTPM
Esophagus	22.8 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	41.7 nTPM
Colon	55.6 nTPM
Small intestine	40.6 nTPM
Rectum	29.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC