Single cell type - GATAD2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GATAD2B
Gene descriptionⁱ Full gene name according to HGNC.	GATA zinc finger domain containing 2B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GATAD2B is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.96
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPS6KB1	Ribosomal protein S6 kinase B1	0.5488	59
PPP1R16B	Protein phosphatase 1 regulatory subunit 16B	0.5364	59
SLC30A7	Solute carrier family 30 member 7	0.5346	55
MAML1	Mastermind like transcriptional coactivator 1	0.5095	14
PDS5A	PDS5 cohesin associated factor A	0.5071	59
TRPM7	Transient receptor potential cation channel subfamily M member 7	0.4950	21
ASXL2	ASXL transcriptional regulator 2	0.4890	59
SP3	Sp3 transcription factor	0.4876	59
MSL2	MSL complex subunit 2	0.4838	24
PCBP2	Poly(rC) binding protein 2	0.4794	10
NR3C1	Nuclear receptor subfamily 3 group C member 1	0.4719	65
NSUN2	NOP2/Sun RNA methyltransferase 2	0.4708	59
FBXW11	F-box and WD repeat domain containing 11	0.4624	65
FOXP1	Forkhead box P1	0.4621	21
BIRC6	Baculoviral IAP repeat containing 6	0.4608	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.1 nTPM
Adipose tissue	35.9 nTPM
Breast	28.4 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	14.4 nTPM
Lung	14.4 nTPM

Astrocytes	53.8 nTPM
Brain	53.8 nTPM

B-cells	30.0 nTPM
Bone marrow	54.0 nTPM
Lymph node	47.8 nTPM
Stomach	39.5 nTPM
Spleen	34.6 nTPM
Adipose tissue	32.6 nTPM
PBMC	29.9 nTPM
Colon	25.5 nTPM
Liver	14.5 nTPM
Breast	12.1 nTPM
Kidney	9.5 nTPM

Dendritic cells	31.9 nTPM
Adipose tissue	42.0 nTPM
PBMC	31.8 nTPM
Breast	21.8 nTPM

Endothelial cells	28.2 nTPM
Skin	40.1 nTPM
Esophagus	37.8 nTPM
Liver	37.6 nTPM
Prostate	36.2 nTPM
Ovary	34.6 nTPM
Endometrium	33.7 nTPM
Skeletal muscle	32.5 nTPM
Testis	32.3 nTPM
Breast	28.0 nTPM
Heart muscle	21.5 nTPM
Lung	18.7 nTPM
Placenta	18.2 nTPM
Eye	15.4 nTPM
Pancreas	7.7 nTPM

Fibroblasts	20.7 nTPM
Skin	37.3 nTPM
Esophagus	28.3 nTPM
Skeletal muscle	26.4 nTPM
Adipose tissue	22.8 nTPM
Breast	20.6 nTPM
Ovary	19.7 nTPM
Prostate	19.2 nTPM
Stomach	16.3 nTPM
Placenta	13.5 nTPM
Lung	13.4 nTPM
Heart muscle	10.2 nTPM

Intestinal goblet cells	15.8 nTPM
Rectum	21.9 nTPM
Small intestine	19.0 nTPM
Colon	6.5 nTPM

Macrophages	23.7 nTPM
Adipose tissue	39.5 nTPM
Esophagus	36.2 nTPM
Bone marrow	35.0 nTPM
Testis	31.4 nTPM
Stomach	29.4 nTPM
Spleen	26.0 nTPM
Lung	24.5 nTPM
Breast	22.7 nTPM
Ovary	22.1 nTPM
Endometrium	21.9 nTPM
Kidney	20.4 nTPM
Skeletal muscle	20.0 nTPM
Prostate	13.8 nTPM
Pancreas	12.8 nTPM
PBMC	0.0 nTPM

Paneth cells	20.7 nTPM
Rectum	23.1 nTPM
Small intestine	22.5 nTPM
Colon	16.5 nTPM

Plasma cells	25.6 nTPM
Adipose tissue	34.2 nTPM
Esophagus	30.7 nTPM
Stomach	27.9 nTPM
Spleen	18.9 nTPM
Bone marrow	16.5 nTPM

Respiratory ciliated cells	15.2 nTPM
Bronchus	17.3 nTPM
Lung	13.1 nTPM

Smooth muscle cells	27.1 nTPM
Bronchus	94.6 nTPM
Skin	30.7 nTPM
Adipose tissue	25.3 nTPM
Esophagus	24.8 nTPM
Skeletal muscle	22.9 nTPM
Endometrium	22.8 nTPM
Prostate	22.2 nTPM
Ovary	20.2 nTPM
Breast	19.2 nTPM
Heart muscle	8.5 nTPM
Pancreas	7.3 nTPM

T-cells	31.2 nTPM
Adipose tissue	48.1 nTPM
Lymph node	46.1 nTPM
Skin	44.7 nTPM
Skeletal muscle	40.3 nTPM
Spleen	37.4 nTPM
Colon	34.7 nTPM
PBMC	32.1 nTPM
Bone marrow	31.8 nTPM
Endometrium	30.9 nTPM
Stomach	30.4 nTPM
Breast	29.7 nTPM
Liver	28.8 nTPM
Esophagus	26.2 nTPM
Lung	25.8 nTPM
Kidney	24.0 nTPM
Ovary	15.6 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	43.8 nTPM
Skin	43.8 nTPM

Cone photoreceptor cells	39.6 nTPM
Eye	39.6 nTPM

Cytotrophoblasts	10.3 nTPM
Placenta	10.3 nTPM

Distal enterocytes	15.1 nTPM
Rectum	21.4 nTPM
Colon	8.7 nTPM

Undifferentiated cells	15.9 nTPM
Rectum	23.2 nTPM
Small intestine	15.2 nTPM
Colon	9.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC