Single cell type - RPL7L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPL7L1
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein L7 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RPL7L1 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KTI12	KTI12 chromatin associated homolog	0.6649	40
B3GALT6	Beta-1,3-galactosyltransferase 6	0.5844	52
NOL11	Nucleolar protein 11	0.5492	39
DDX24	DEAD-box helicase 24	0.5422	24
KRR1	KRR1 small subunit processome component homolog	0.5327	39
ZBTB33	Zinc finger and BTB domain containing 33	0.5180	65
EXOSC6	Exosome component 6	0.4973	24
ZNF195	Zinc finger protein 195	0.4938	52
POLR1E	RNA polymerase I subunit E	0.4915	32
NR5A1	Nuclear receptor subfamily 5 group A member 1	0.4886	52
IGFBP2	Insulin like growth factor binding protein 2	0.4858	40
CRCP	CGRP receptor component	0.4800	52
AMHR2	Anti-Mullerian hormone receptor type 2	0.4782	52
THRAP3	Thyroid hormone receptor associated protein 3	0.4773	10
GRWD1	Glutamate rich WD repeat containing 1	0.4738	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	56.2 nTPM
Breast	61.3 nTPM
Adipose tissue	51.1 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	103.0 nTPM
Lung	103.0 nTPM

Astrocytes	12.7 nTPM
Brain	12.7 nTPM

B-cells	69.3 nTPM
PBMC	101.4 nTPM
Colon	86.3 nTPM
Kidney	85.7 nTPM
Adipose tissue	83.2 nTPM
Liver	79.5 nTPM
Stomach	72.7 nTPM
Spleen	58.5 nTPM
Breast	48.1 nTPM
Lymph node	39.1 nTPM
Bone marrow	38.5 nTPM

Dendritic cells	77.7 nTPM
Adipose tissue	98.8 nTPM
Breast	70.3 nTPM
PBMC	63.8 nTPM

Endothelial cells	71.6 nTPM
Testis	110.2 nTPM
Lung	106.0 nTPM
Pancreas	104.2 nTPM
Ovary	80.9 nTPM
Endometrium	73.2 nTPM
Prostate	72.5 nTPM
Placenta	65.4 nTPM
Skin	65.4 nTPM
Liver	65.1 nTPM
Eye	61.5 nTPM
Skeletal muscle	57.2 nTPM
Heart muscle	51.3 nTPM
Breast	49.7 nTPM
Esophagus	39.8 nTPM

Enteroendocrine cells	94.4 nTPM
Colon	120.8 nTPM
Rectum	67.9 nTPM

Fibroblasts	67.5 nTPM
Lung	116.2 nTPM
Ovary	89.2 nTPM
Prostate	78.7 nTPM
Heart muscle	73.1 nTPM
Adipose tissue	70.3 nTPM
Skeletal muscle	63.2 nTPM
Breast	62.1 nTPM
Placenta	58.3 nTPM
Skin	50.6 nTPM
Stomach	43.0 nTPM
Esophagus	37.6 nTPM

Intestinal goblet cells	44.4 nTPM
Rectum	48.1 nTPM
Colon	46.5 nTPM
Small intestine	38.8 nTPM

Macrophages	44.5 nTPM
Lung	91.0 nTPM
Ovary	71.7 nTPM
Testis	61.6 nTPM
Kidney	58.2 nTPM
Endometrium	53.7 nTPM
Bone marrow	51.2 nTPM
Adipose tissue	48.8 nTPM
Breast	48.8 nTPM
Skeletal muscle	39.7 nTPM
Prostate	38.9 nTPM
Esophagus	29.9 nTPM
Pancreas	28.0 nTPM
Spleen	27.9 nTPM
Stomach	17.6 nTPM
PBMC	0.0 nTPM

Paneth cells	30.8 nTPM
Rectum	52.0 nTPM
Small intestine	33.8 nTPM
Colon	6.5 nTPM

Plasma cells	56.1 nTPM
Spleen	79.7 nTPM
Bone marrow	67.6 nTPM
Adipose tissue	64.6 nTPM
Stomach	44.3 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	71.3 nTPM
Lung	104.9 nTPM
Bronchus	37.7 nTPM

Smooth muscle cells	64.0 nTPM
Ovary	109.8 nTPM
Pancreas	94.4 nTPM
Prostate	81.6 nTPM
Heart muscle	62.7 nTPM
Skeletal muscle	60.4 nTPM
Skin	58.9 nTPM
Endometrium	58.0 nTPM
Breast	54.6 nTPM
Adipose tissue	53.1 nTPM
Esophagus	46.5 nTPM
Bronchus	24.4 nTPM

Basal keratinocytes	57.1 nTPM
Skin	57.1 nTPM

Basal prostatic cells	89.3 nTPM
Prostate	89.3 nTPM

Basal respiratory cells	70.6 nTPM
Bronchus	70.6 nTPM

Basal squamous epithelial cells	67.7 nTPM
Esophagus	67.7 nTPM

T-cells	65.6 nTPM
Colon	107.8 nTPM
Adipose tissue	97.8 nTPM
PBMC	96.4 nTPM
Lung	80.5 nTPM
Liver	79.9 nTPM
Kidney	75.3 nTPM
Skin	71.3 nTPM
Ovary	66.8 nTPM
Endometrium	66.1 nTPM
Skeletal muscle	66.1 nTPM
Breast	66.1 nTPM
Stomach	51.0 nTPM
Spleen	45.9 nTPM
Bone marrow	45.3 nTPM
Prostate	37.9 nTPM
Lymph node	35.1 nTPM
Esophagus	26.2 nTPM

Undifferentiated cells	52.5 nTPM
Colon	60.6 nTPM
Small intestine	49.9 nTPM
Rectum	47.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC