Single cell type - NOL11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NOL11
Gene descriptionⁱ Full gene name according to HGNC.	Nucleolar protein 11
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NOL11 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.95
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPL7L1	Ribosomal protein L7 like 1	0.5492	52
ZNF770	Zinc finger protein 770	0.5363	13
KANSL2	KAT8 regulatory NSL complex subunit 2	0.5332	7
GART	Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	0.5309	39
NGDN	Neuroguidin	0.5165	39
TRMT10C	TRNA methyltransferase 10C, mitochondrial RNase P subunit	0.5040	22
POLR1E	RNA polymerase I subunit E	0.5029	32
GAR1	GAR1 ribonucleoprotein	0.5001	39
TFB2M	Transcription factor B2, mitochondrial	0.4977	67
LSG1	Large 60S subunit nuclear export GTPase 1	0.4924	60
WDR75	WD repeat domain 75	0.4862	59
TGS1	Trimethylguanosine synthase 1	0.4860	59
PNO1	Partner of NOB1 homolog	0.4845	39
GRWD1	Glutamate rich WD repeat containing 1	0.4843	39
HEATR1	HEAT repeat containing 1	0.4812	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.5 nTPM
Adipose tissue	30.1 nTPM
Breast	20.9 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	18.6 nTPM
Lung	18.6 nTPM

Astrocytes	10.4 nTPM
Brain	10.4 nTPM

B-cells	33.7 nTPM
Stomach	49.9 nTPM
Spleen	48.2 nTPM
Lymph node	43.0 nTPM
Adipose tissue	39.0 nTPM
PBMC	38.6 nTPM
Bone marrow	38.5 nTPM
Breast	29.4 nTPM
Liver	21.5 nTPM
Colon	19.2 nTPM
Kidney	9.5 nTPM

Dendritic cells	33.8 nTPM
Adipose tissue	37.5 nTPM
PBMC	35.8 nTPM
Breast	28.1 nTPM

Endothelial cells	26.0 nTPM
Lung	40.6 nTPM
Pancreas	38.6 nTPM
Esophagus	34.5 nTPM
Prostate	33.0 nTPM
Skeletal muscle	30.0 nTPM
Endometrium	28.0 nTPM
Placenta	25.0 nTPM
Skin	23.9 nTPM
Ovary	22.4 nTPM
Heart muscle	22.0 nTPM
Testis	19.3 nTPM
Breast	17.2 nTPM
Eye	16.2 nTPM
Liver	13.7 nTPM

Fibroblasts	25.0 nTPM
Ovary	35.5 nTPM
Prostate	34.0 nTPM
Lung	31.3 nTPM
Stomach	31.2 nTPM
Placenta	28.6 nTPM
Skeletal muscle	23.2 nTPM
Adipose tissue	21.6 nTPM
Breast	18.4 nTPM
Esophagus	17.5 nTPM
Skin	17.0 nTPM
Heart muscle	16.3 nTPM

Intestinal goblet cells	16.8 nTPM
Rectum	20.0 nTPM
Colon	19.3 nTPM
Small intestine	11.0 nTPM

Macrophages	15.7 nTPM
Bone marrow	25.0 nTPM
Pancreas	23.0 nTPM
Lung	21.4 nTPM
Breast	20.3 nTPM
Spleen	19.7 nTPM
Adipose tissue	18.6 nTPM
Testis	18.0 nTPM
Endometrium	17.1 nTPM
Kidney	15.8 nTPM
Esophagus	15.8 nTPM
Ovary	15.0 nTPM
Skeletal muscle	10.9 nTPM
Prostate	9.1 nTPM
Stomach	5.9 nTPM
PBMC	0.0 nTPM

Paneth cells	9.2 nTPM
Rectum	16.8 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	17.4 nTPM
Spleen	25.3 nTPM
Stomach	20.4 nTPM
Adipose tissue	18.8 nTPM
Bone marrow	16.5 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	24.8 nTPM
Lung	30.6 nTPM
Bronchus	19.0 nTPM

Smooth muscle cells	21.8 nTPM
Pancreas	32.4 nTPM
Ovary	30.9 nTPM
Endometrium	25.1 nTPM
Prostate	23.5 nTPM
Skeletal muscle	19.5 nTPM
Adipose tissue	19.3 nTPM
Breast	19.0 nTPM
Bronchus	18.7 nTPM
Esophagus	18.6 nTPM
Skin	17.1 nTPM
Heart muscle	15.5 nTPM

T-cells	32.0 nTPM
Lymph node	57.9 nTPM
Stomach	39.4 nTPM
Esophagus	39.3 nTPM
Adipose tissue	38.2 nTPM
Spleen	38.1 nTPM
PBMC	37.7 nTPM
Bone marrow	35.0 nTPM
Kidney	33.6 nTPM
Lung	33.4 nTPM
Breast	32.5 nTPM
Ovary	28.9 nTPM
Endometrium	26.8 nTPM
Colon	26.6 nTPM
Skin	26.2 nTPM
Skeletal muscle	25.2 nTPM
Liver	20.8 nTPM
Prostate	4.7 nTPM

Basal prostatic cells	38.9 nTPM
Prostate	38.9 nTPM

Basal respiratory cells	30.5 nTPM
Bronchus	30.5 nTPM

Basal squamous epithelial cells	27.9 nTPM
Esophagus	27.9 nTPM

Cone photoreceptor cells	14.6 nTPM
Eye	14.6 nTPM

Undifferentiated cells	21.9 nTPM
Colon	24.8 nTPM
Small intestine	21.9 nTPM
Rectum	19.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC