Single cell type - ITPRIP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITPRIP
Gene descriptionⁱ Full gene name according to HGNC.	Inositol 1,4,5-trisphosphate receptor interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Squamous epithelial cells, Adipocytes, Hepatic stellate cells, Suprabasal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTCEpi)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Squamous epithelial cells, Adipocytes, Hepatic stellate cells, Suprabasal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ITPRIP is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RASSF10	Ras association domain family member 10	0.6266	61
ADRB2	Adrenoceptor beta 2	0.6244	61
FABP5	Fatty acid binding protein 5	0.6188	61
SOX7	SRY-box transcription factor 7	0.6157	14
RALGDS	Ral guanine nucleotide dissociation stimulator	0.6126	44
ZBTB2	Zinc finger and BTB domain containing 2	0.5995	44
ADAT3	Adenosine deaminase tRNA specific 3	0.5972	61
A2ML1	Alpha-2-macroglobulin like 1	0.5905	61
BHLHE40	Basic helix-loop-helix family member e40	0.5806	61
ZNF750	Zinc finger protein 750	0.5742	61
CALML3	Calmodulin like 3	0.5689	61
UGT1A7	UDP glucuronosyltransferase family 1 member A7	0.5667	61
SPINK7	Serine peptidase inhibitor Kazal type 7	0.5661	61
PGLYRP3	Peptidoglycan recognition protein 3	0.5653	61
NFE2L2	Nuclear factor, erythroid 2 like 2	0.5648	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	8.3 nTPM
Lung	8.3 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	9.0 nTPM
Lymph node	19.1 nTPM
Colon	14.4 nTPM
Adipose tissue	13.5 nTPM
Spleen	9.3 nTPM
PBMC	8.5 nTPM
Stomach	7.3 nTPM
Bone marrow	6.6 nTPM
Breast	6.6 nTPM
Liver	4.6 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	37.9 nTPM
Skin	37.9 nTPM

Dendritic cells	37.0 nTPM
Adipose tissue	76.7 nTPM
Breast	34.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	42.5 nTPM
Skin	80.7 nTPM
Liver	78.9 nTPM
Skeletal muscle	65.5 nTPM
Prostate	52.3 nTPM
Eye	48.6 nTPM
Ovary	48.3 nTPM
Lung	46.8 nTPM
Endometrium	42.5 nTPM
Esophagus	32.0 nTPM
Placenta	27.8 nTPM
Pancreas	27.0 nTPM
Testis	22.5 nTPM
Heart muscle	11.8 nTPM
Breast	10.5 nTPM

Fibroblasts	15.5 nTPM
Prostate	61.7 nTPM
Stomach	26.7 nTPM
Lung	15.7 nTPM
Skin	14.7 nTPM
Skeletal muscle	14.1 nTPM
Esophagus	10.2 nTPM
Placenta	8.0 nTPM
Ovary	6.1 nTPM
Heart muscle	5.0 nTPM
Breast	4.8 nTPM
Adipose tissue	4.1 nTPM

Intestinal goblet cells	2.6 nTPM
Rectum	3.3 nTPM
Small intestine	2.3 nTPM
Colon	2.2 nTPM

Macrophages	28.1 nTPM
Stomach	73.3 nTPM
Adipose tissue	67.2 nTPM
Skeletal muscle	52.2 nTPM
Spleen	43.5 nTPM
Esophagus	29.9 nTPM
Endometrium	26.0 nTPM
Prostate	22.9 nTPM
Testis	18.0 nTPM
Lung	17.9 nTPM
Ovary	16.3 nTPM
Bone marrow	16.3 nTPM
Breast	14.8 nTPM
Kidney	13.7 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	0.5 nTPM
Rectum	1.6 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	13.6 nTPM
Adipose tissue	43.2 nTPM
Bone marrow	8.2 nTPM
Spleen	6.7 nTPM
Esophagus	6.1 nTPM
Stomach	3.8 nTPM

Respiratory ciliated cells	5.2 nTPM
Bronchus	7.4 nTPM
Lung	2.9 nTPM

Smooth muscle cells	14.7 nTPM
Prostate	32.5 nTPM
Ovary	18.7 nTPM
Adipose tissue	18.1 nTPM
Skin	17.8 nTPM
Skeletal muscle	16.2 nTPM
Pancreas	15.0 nTPM
Endometrium	13.1 nTPM
Esophagus	10.9 nTPM
Breast	9.4 nTPM
Heart muscle	6.5 nTPM
Bronchus	2.9 nTPM

T-cells	23.8 nTPM
Adipose tissue	64.3 nTPM
Skeletal muscle	40.8 nTPM
Spleen	35.7 nTPM
Colon	29.0 nTPM
Endometrium	27.2 nTPM
Skin	26.7 nTPM
Lymph node	26.1 nTPM
Stomach	24.9 nTPM
Breast	23.8 nTPM
Esophagus	19.7 nTPM
Liver	17.2 nTPM
Ovary	15.6 nTPM
Bone marrow	14.9 nTPM
Prostate	14.2 nTPM
Kidney	10.9 nTPM
PBMC	6.8 nTPM
Lung	6.1 nTPM

Cholangiocytes	1.5 nTPM
Liver	1.5 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Early spermatids	6.3 nTPM
Testis	6.3 nTPM

Endometrial stromal cells	10.0 nTPM
Endometrium	10.0 nTPM

Undifferentiated cells	1.1 nTPM
Rectum	1.7 nTPM
Small intestine	1.3 nTPM
Colon	0.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC