Single cell type - ENDOD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENDOD1
Gene descriptionⁱ Full gene name according to HGNC.	Endonuclease domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Distal enterocytes, Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Distal enterocytes, Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ENDOD1 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BMP3	Bone morphogenetic protein 3	0.6801	40
LAMA1	Laminin subunit alpha 1	0.6007	53
PAQR8	Progestin and adipoQ receptor family member 8	0.5982	53
NR5A2	Nuclear receptor subfamily 5 group A member 2	0.5603	40
ALDH18A1	Aldehyde dehydrogenase 18 family member A1	0.5573	40
PRR15	Proline rich 15	0.5483	53
TMEM200A	Transmembrane protein 200A	0.5471	40
CES3	Carboxylesterase 3	0.5431	53
CASP6	Caspase 6	0.5419	40
PLEKHH1	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.5310	42
TRANK1	Tetratricopeptide repeat and ankyrin repeat containing 1	0.5250	40
TRPC1	Transient receptor potential cation channel subfamily C member 1	0.5171	40
IHH	Indian hedgehog signaling molecule	0.5167	40
TLL2	Tolloid like 2	0.5155	40
TRPM6	Transient receptor potential cation channel subfamily M member 6	0.5135	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.1 nTPM
Adipose tissue	37.0 nTPM
Breast	31.1 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	19.4 nTPM
Lung	19.4 nTPM

Astrocytes	22.9 nTPM
Brain	22.9 nTPM

B-cells	15.6 nTPM
PBMC	25.7 nTPM
Bone marrow	25.3 nTPM
Colon	22.3 nTPM
Spleen	21.5 nTPM
Stomach	20.0 nTPM
Lymph node	13.6 nTPM
Adipose tissue	11.1 nTPM
Kidney	9.5 nTPM
Liver	3.9 nTPM
Breast	2.6 nTPM

Dendritic cells	9.9 nTPM
Breast	14.6 nTPM
Adipose tissue	11.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	32.4 nTPM
Liver	86.3 nTPM
Heart muscle	67.8 nTPM
Skeletal muscle	38.6 nTPM
Esophagus	37.5 nTPM
Lung	37.4 nTPM
Ovary	33.8 nTPM
Testis	28.5 nTPM
Breast	28.0 nTPM
Prostate	25.1 nTPM
Endometrium	21.5 nTPM
Eye	20.3 nTPM
Skin	16.0 nTPM
Placenta	13.1 nTPM
Pancreas	0.0 nTPM

Fibroblasts	16.9 nTPM
Heart muscle	37.3 nTPM
Lung	21.2 nTPM
Skeletal muscle	18.1 nTPM
Esophagus	17.4 nTPM
Ovary	17.2 nTPM
Adipose tissue	17.1 nTPM
Stomach	16.3 nTPM
Placenta	14.2 nTPM
Breast	11.5 nTPM
Prostate	9.8 nTPM
Skin	6.4 nTPM

Intestinal goblet cells	22.2 nTPM
Rectum	31.8 nTPM
Colon	23.5 nTPM
Small intestine	11.2 nTPM

Macrophages	15.6 nTPM
PBMC	136.4 nTPM
Esophagus	14.2 nTPM
Prostate	11.5 nTPM
Skeletal muscle	9.1 nTPM
Kidney	7.6 nTPM
Endometrium	7.5 nTPM
Ovary	7.5 nTPM
Lung	7.3 nTPM
Bone marrow	6.2 nTPM
Stomach	5.9 nTPM
Adipose tissue	5.3 nTPM
Testis	5.2 nTPM
Breast	5.2 nTPM
Pancreas	2.5 nTPM
Spleen	2.1 nTPM

Paneth cells	44.5 nTPM
Colon	62.6 nTPM
Rectum	44.5 nTPM
Small intestine	26.3 nTPM

Plasma cells	3.3 nTPM
Adipose tissue	8.4 nTPM
Bone marrow	3.3 nTPM
Stomach	2.9 nTPM
Spleen	1.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.8 nTPM
Bronchus	10.2 nTPM
Lung	1.5 nTPM

Smooth muscle cells	34.5 nTPM
Heart muscle	68.1 nTPM
Ovary	61.4 nTPM
Adipose tissue	53.5 nTPM
Skeletal muscle	48.6 nTPM
Breast	45.5 nTPM
Esophagus	34.1 nTPM
Prostate	21.6 nTPM
Endometrium	19.0 nTPM
Pancreas	13.3 nTPM
Skin	12.6 nTPM
Bronchus	1.8 nTPM

T-cells	8.8 nTPM
Adipose tissue	18.6 nTPM
Stomach	15.0 nTPM
Colon	14.2 nTPM
Skeletal muscle	13.2 nTPM
PBMC	11.8 nTPM
Bone marrow	10.3 nTPM
Endometrium	9.5 nTPM
Breast	9.0 nTPM
Spleen	8.3 nTPM
Esophagus	6.6 nTPM
Skin	6.4 nTPM
Lymph node	6.0 nTPM
Liver	5.6 nTPM
Kidney	5.5 nTPM
Lung	4.5 nTPM
Ovary	4.5 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	8.0 nTPM
Skin	8.0 nTPM

Basal prostatic cells	18.9 nTPM
Prostate	18.9 nTPM

Basal respiratory cells	14.9 nTPM
Bronchus	14.9 nTPM

Basal squamous epithelial cells	7.4 nTPM
Esophagus	7.4 nTPM

Undifferentiated cells	21.0 nTPM
Rectum	31.9 nTPM
Colon	18.1 nTPM
Small intestine	13.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC