Single cell type - RASA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RASA2
Gene descriptionⁱ Full gene name according to HGNC.	RAS p21 protein activator 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RASA2 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DIAPH1	Diaphanous related formin 1	0.5527	63
ARNTL	Aryl hydrocarbon receptor nuclear translocator like	0.5466	24
FBXO28	F-box protein 28	0.5325	22
ARHGEF3	Rho guanine nucleotide exchange factor 3	0.5296	21
NFAT5	Nuclear factor of activated T cells 5	0.5293	44
PARP8	Poly(ADP-ribose) polymerase family member 8	0.5191	24
CDK17	Cyclin dependent kinase 17	0.5139	59
WDFY1	WD repeat and FYVE domain containing 1	0.5026	44
ZNF207	Zinc finger protein 207	0.5014	52
IL12RB2	Interleukin 12 receptor subunit beta 2	0.4988	58
KPNA1	Karyopherin subunit alpha 1	0.4914	31
CWF19L1	CWF19 like cell cycle control factor 1	0.4822	23
PRKCI	Protein kinase C iota	0.4760	44
TRIM33	Tripartite motif containing 33	0.4758	44
DENND4A	DENN domain containing 4A	0.4694	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.2 nTPM
Breast	24.7 nTPM
Adipose tissue	23.8 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	23.6 nTPM
Lung	23.6 nTPM

Astrocytes	59.4 nTPM
Brain	59.4 nTPM

B-cells	55.1 nTPM
Lymph node	101.8 nTPM
Bone marrow	83.4 nTPM
Stomach	75.9 nTPM
Spleen	72.7 nTPM
Adipose tissue	68.6 nTPM
PBMC	41.4 nTPM
Breast	38.8 nTPM
Colon	33.5 nTPM
Liver	25.7 nTPM
Kidney	9.5 nTPM

Dendritic cells	104.9 nTPM
Adipose tissue	221.1 nTPM
Breast	73.7 nTPM
PBMC	20.0 nTPM

Endothelial cells	22.7 nTPM
Prostate	40.7 nTPM
Lung	34.3 nTPM
Skin	28.5 nTPM
Breast	27.4 nTPM
Skeletal muscle	26.6 nTPM
Endometrium	22.7 nTPM
Esophagus	21.6 nTPM
Ovary	20.1 nTPM
Pancreas	19.3 nTPM
Heart muscle	17.9 nTPM
Testis	17.7 nTPM
Liver	17.4 nTPM
Eye	12.9 nTPM
Placenta	11.3 nTPM

Fibroblasts	20.4 nTPM
Breast	32.2 nTPM
Prostate	31.1 nTPM
Skin	31.1 nTPM
Skeletal muscle	26.9 nTPM
Adipose tissue	21.3 nTPM
Esophagus	19.7 nTPM
Stomach	16.3 nTPM
Lung	15.7 nTPM
Heart muscle	13.5 nTPM
Ovary	9.8 nTPM
Placenta	6.9 nTPM

Intestinal goblet cells	15.2 nTPM
Rectum	23.5 nTPM
Small intestine	12.9 nTPM
Colon	9.3 nTPM

Macrophages	34.3 nTPM
Skeletal muscle	68.7 nTPM
Stomach	52.7 nTPM
Bone marrow	48.7 nTPM
Spleen	46.7 nTPM
Lung	45.7 nTPM
Adipose tissue	44.3 nTPM
Testis	37.8 nTPM
Esophagus	37.7 nTPM
Ovary	29.8 nTPM
Prostate	27.5 nTPM
Endometrium	26.3 nTPM
Breast	25.5 nTPM
Kidney	20.4 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	21.7 nTPM
Colon	36.2 nTPM
Rectum	17.8 nTPM
Small intestine	11.3 nTPM

Plasma cells	94.9 nTPM
Adipose tissue	167.8 nTPM
Spleen	95.8 nTPM
Stomach	87.3 nTPM
Bone marrow	74.2 nTPM
Esophagus	49.4 nTPM

Respiratory ciliated cells	15.5 nTPM
Bronchus	17.8 nTPM
Lung	13.1 nTPM

Smooth muscle cells	27.2 nTPM
Bronchus	84.2 nTPM
Skin	31.0 nTPM
Prostate	24.1 nTPM
Adipose tissue	23.8 nTPM
Ovary	23.5 nTPM
Breast	21.3 nTPM
Heart muscle	21.1 nTPM
Endometrium	21.1 nTPM
Esophagus	20.1 nTPM
Skeletal muscle	17.8 nTPM
Pancreas	11.5 nTPM

T-cells	88.3 nTPM
Lymph node	162.6 nTPM
Stomach	158.2 nTPM
Adipose tissue	135.6 nTPM
Spleen	133.8 nTPM
Bone marrow	127.9 nTPM
Skeletal muscle	105.2 nTPM
Esophagus	85.2 nTPM
Endometrium	79.5 nTPM
Liver	77.8 nTPM
Ovary	75.7 nTPM
PBMC	65.9 nTPM
Breast	62.3 nTPM
Skin	56.1 nTPM
Colon	54.6 nTPM
Lung	45.6 nTPM
Prostate	42.6 nTPM
Kidney	32.2 nTPM

Basal keratinocytes	21.5 nTPM
Skin	21.5 nTPM

Basal prostatic cells	52.0 nTPM
Prostate	52.0 nTPM

Basal respiratory cells	15.8 nTPM
Bronchus	15.8 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Undifferentiated cells	18.7 nTPM
Colon	21.4 nTPM
Rectum	21.3 nTPM
Small intestine	13.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC