Single cell type - WHAMM - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WHAMM
Gene descriptionⁱ Full gene name according to HGNC.	WASP homolog associated with actin, golgi membranes and microtubules
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

WHAMM is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
YRDC	YrdC N6-threonylcarbamoyltransferase domain containing	0.6054	22
STK17A	Serine/threonine kinase 17a	0.5831	22
DUSP5	Dual specificity phosphatase 5	0.5605	22
KRTAP4-12	Keratin associated protein 4-12	0.5604	22
PRELID3B	PRELI domain containing 3B	0.5576	22
RAB22A	RAB22A, member RAS oncogene family	0.5524	22
TRAF4	TNF receptor associated factor 4	0.5512	22
KRT17	Keratin 17	0.5504	22
PNRC2	Proline rich nuclear receptor coactivator 2	0.5497	22
MKNK2	MAPK interacting serine/threonine kinase 2	0.5471	7
CXCL8	C-X-C motif chemokine ligand 8	0.5455	22
ADGRF1	Adhesion G protein-coupled receptor F1	0.5440	22
SLC14A1	Solute carrier family 14 member 1 (Kidd blood group)	0.5407	22
ZNF836	Zinc finger protein 836	0.5374	22
GCLM	Glutamate-cysteine ligase modifier subunit	0.5336	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.6 nTPM
Breast	43.5 nTPM
Adipose tissue	29.8 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	17.3 nTPM
Lung	17.3 nTPM

Astrocytes	18.9 nTPM
Brain	18.9 nTPM

B-cells	37.1 nTPM
Adipose tissue	68.2 nTPM
Lymph node	59.2 nTPM
Colon	41.5 nTPM
Stomach	37.3 nTPM
Kidney	33.4 nTPM
Spleen	32.2 nTPM
PBMC	29.9 nTPM
Breast	28.1 nTPM
Bone marrow	26.2 nTPM
Liver	14.9 nTPM

Dendritic cells	47.3 nTPM
Adipose tissue	62.0 nTPM
Breast	48.1 nTPM
PBMC	31.8 nTPM

Endothelial cells	23.2 nTPM
Prostate	39.3 nTPM
Skeletal muscle	36.0 nTPM
Breast	35.0 nTPM
Testis	27.9 nTPM
Liver	26.6 nTPM
Ovary	24.3 nTPM
Esophagus	23.8 nTPM
Endometrium	22.7 nTPM
Heart muscle	20.5 nTPM
Skin	19.0 nTPM
Placenta	17.6 nTPM
Eye	14.6 nTPM
Pancreas	11.6 nTPM
Lung	6.2 nTPM

Fibroblasts	18.7 nTPM
Prostate	43.1 nTPM
Lung	23.4 nTPM
Skeletal muscle	22.0 nTPM
Breast	20.4 nTPM
Heart muscle	17.1 nTPM
Adipose tissue	17.0 nTPM
Skin	15.8 nTPM
Esophagus	14.7 nTPM
Stomach	11.9 nTPM
Ovary	10.4 nTPM
Placenta	9.6 nTPM

Intestinal goblet cells	19.4 nTPM
Colon	25.0 nTPM
Rectum	19.2 nTPM
Small intestine	14.0 nTPM

Macrophages	25.4 nTPM
Adipose tissue	50.1 nTPM
Prostate	42.3 nTPM
PBMC	40.9 nTPM
Endometrium	36.6 nTPM
Breast	31.8 nTPM
Skeletal muscle	30.4 nTPM
Ovary	23.8 nTPM
Esophagus	20.4 nTPM
Testis	19.7 nTPM
Stomach	17.6 nTPM
Lung	16.6 nTPM
Bone marrow	16.3 nTPM
Spleen	14.5 nTPM
Kidney	12.9 nTPM
Pancreas	7.7 nTPM

Paneth cells	15.5 nTPM
Colon	19.7 nTPM
Rectum	15.5 nTPM
Small intestine	11.3 nTPM

Plasma cells	24.1 nTPM
Adipose tissue	34.2 nTPM
Stomach	27.1 nTPM
Bone marrow	26.4 nTPM
Spleen	20.5 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	7.1 nTPM
Bronchus	8.4 nTPM
Lung	5.8 nTPM

Smooth muscle cells	19.5 nTPM
Prostate	33.1 nTPM
Skeletal muscle	28.9 nTPM
Breast	26.0 nTPM
Ovary	22.6 nTPM
Adipose tissue	21.0 nTPM
Esophagus	20.1 nTPM
Endometrium	18.4 nTPM
Heart muscle	17.8 nTPM
Skin	14.7 nTPM
Pancreas	8.2 nTPM
Bronchus	3.8 nTPM

T-cells	36.1 nTPM
Endometrium	55.5 nTPM
Lymph node	47.8 nTPM
Skeletal muscle	45.8 nTPM
Adipose tissue	45.7 nTPM
Breast	45.6 nTPM
PBMC	43.9 nTPM
Colon	43.7 nTPM
Prostate	42.6 nTPM
Spleen	35.9 nTPM
Liver	32.0 nTPM
Stomach	30.5 nTPM
Kidney	30.2 nTPM
Skin	29.0 nTPM
Bone marrow	28.9 nTPM
Ovary	26.7 nTPM
Esophagus	19.7 nTPM
Lung	10.6 nTPM

Basal keratinocytes	26.5 nTPM
Skin	26.5 nTPM

Basal prostatic cells	42.8 nTPM
Prostate	42.8 nTPM

Basal respiratory cells	6.6 nTPM
Bronchus	6.6 nTPM

Basal squamous epithelial cells	34.1 nTPM
Esophagus	34.1 nTPM

Undifferentiated cells	13.8 nTPM
Colon	14.9 nTPM
Small intestine	14.1 nTPM
Rectum	12.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC